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• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleotides Purine ribonucleoside monophosphates
• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleotides Purine ribonucleotides Purine ribonucleoside monophosphates
• Solvents and Organic Chemicals Organic Compounds Acids/Esters
• Other Chemical Reagents

Disodium 5'-guanylate (CAS No. 5550-12-9): A Comprehensive Overview

Disodium 5'-guanylate, chemically identified by the CAS number 5550-12-9, is a significant compound in the field of biochemical research and pharmaceutical applications. This nucleotide derivative plays a crucial role in various biological processes, making it a subject of extensive study and utilization in both academic and industrial settings.

The compound is structurally derived from guanine, one of the fundamental purine bases found in DNA and RNA. Specifically, Disodium 5'-guanylate consists of guanine linked to a ribose sugar, with a sodium salt formulation that enhances its solubility in aqueous solutions. This solubility property makes it particularly valuable for use in biochemical assays, cell culture media, and as an intermediate in the synthesis of more complex nucleotide-based therapeutics.

In recent years, Disodium 5'-guanylate has garnered attention for its potential applications in the development of novel therapeutic agents. One of the most promising areas of research involves its role in modulating cellular signaling pathways. Guanylate cyclase (GC), an enzyme that catalyzes the conversion of GTP to cyclic GMP (cGMP), is a key target for Disodium 5'-guanylate. cGMP acts as a second messenger in numerous cellular processes, including vasodilation, neurotransmission, and phototransduction. By influencing GC activity, Disodium 5'-guanylate has been explored as a potential therapeutic for conditions such as hypertension and erectile dysfunction.

Moreover, the compound has shown promise in the field of regenerative medicine. Studies have demonstrated that Disodium 5'-guanylate can stimulate the proliferation of stem cells and promote tissue repair. This effect is attributed to its ability to activate cGMP-dependent signaling cascades, which are essential for cell growth and differentiation. These findings have opened new avenues for treating injuries and degenerative diseases where tissue regeneration is critical.

Another area where Disodium 5'-guanylate has been extensively studied is immunology. The compound has been found to enhance immune responses by activating immune cells such as T-lymphocytes and macrophages. This immunomodulatory effect makes it a candidate for developing vaccines and adjuvants that can boost the body's defense mechanisms against pathogens.

The synthesis of Disodium 5'-guanylate involves a multi-step process that begins with the phosphorylation of guanine to form guanosine triphosphate (GTP). Subsequent enzymatic or chemical cleavage yields guanosine monophosphate (GMP), which is then converted to 5'-guanylic acid. The final step involves sodium salt formation to produce Disodium 5'-guanylate. This synthetic route ensures high purity and yield, making it suitable for pharmaceutical-grade applications.

In terms of analytical techniques, Disodium 5'-guanylate can be characterized using various spectroscopic methods such as nuclear magnetic resonance (NMR) spectroscopy, high-performance liquid chromatography (HPLC), and mass spectrometry (MS). These techniques provide detailed information about the compound's structure, purity, and molecular interactions. Additionally, its solubility profile has been thoroughly investigated to optimize its use in different formulations.

The safety profile of Disodium 5'-guanylate has been extensively evaluated through preclinical studies. The compound has demonstrated low toxicity at relevant concentrations, making it suitable for both in vitro and in vivo applications. However, as with any biochemical compound, careful consideration must be given to dosing and administration protocols to ensure efficacy while minimizing potential side effects.

Future research directions for Disodium 5'-guanylate include exploring its potential in gene therapy and drug delivery systems. The ability to modify nucleotide derivatives opens up possibilities for developing targeted therapies that can specifically address certain genetic disorders or enhance the bioavailability of other drugs.

In conclusion, Disodium 5'-guanylate (CAS No. 5550-12-9) is a versatile compound with significant implications in biochemical research and pharmaceutical development. Its role in cellular signaling, tissue regeneration, immunomodulation, and potential applications in gene therapy highlight its importance as a research tool and therapeutic agent. As scientific understanding continues to evolve, Disodium 5'-guanylate is poised to play an even greater role in advancing medical treatments and biotechnological innovations.

• 65128-55-4(5'-Guanylic acid,monomethyl ester (9CI))
• 54684-83-2(polyguanylic acid (5') potassium salt)
• 80702-47-2(Ribotide)
• 40732-48-7(Guanosine 3’,5’-Cyclic Monophosphate Sodium Salt)
• 6027-83-4(Guanosine-3'-monophosphate Disodium Salt (mixture of 2’&3’ isomers))
• 38966-30-2(Calcium 5'-guanylate)
• 11063-53-9(5'-Guanylic acid, zinc salt (1:1) (8CI,9CI))
• 14635-71-3(5'-Guanylic acid, N-methyl-, sodium salt (1:2))
• 22886-44-8(Guanosine, guanylyl-(2'®5')- (7CI,8CI,9CI))
• 179382-90-2(5'-Guanylic-8-t acid,diammonium salt (9CI))