• 1. An alkynylboronatecycloaddition strategy to functionalised benzyne derivatives?
  James D. Kirkham,Patrick M. Delaney,George J. Ellames,Eleanor C. Row,Joseph P. A. Harrity Chem. Commun., 2010,46, 5154-5156
• 2. An alumina stabilized graphene oxide wrapped SnO2 hollow sphere LIB anode with improved lithium storage?
  Xiang Liu,Qian Sun,A. B. Djuri?i?,Maohai Xie,Baohu Dai,Jinyao Tang,Charles Surya,Changzhong Liao,Kaimin Shih RSC Adv., 2015,5, 100783-100789
• 3. An integrated microfluidic platform for sensitive and rapid detection of biological toxins?
  Robert J. Meagher,Anson V. Hatch,Ronald F. Renzi,Anup K. Singh Lab Chip, 2008,8, 2046-2053
• 4. An integrated droplet-digital microfluidic system for on-demand droplet creation, mixing, incubation, and sorting?
  Lab Chip, 2019,19, 524-535
• 5. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Phenol ethers
• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers

3-Bromo-2-(2'-chlorobenzyloxy)-5-methylphenylboronic Acid: A Comprehensive Overview

The compound 3-Bromo-2-(2'-chlorobenzyloxy)-5-methylphenylboronic Acid (CAS No. 849052-17-1) is a highly specialized organic compound with significant applications in the field of organic synthesis and materials science. This compound is characterized by its unique structure, which combines a bromine atom, a chlorobenzyl group, and a methyl group attached to a phenyl ring, with a boronic acid functionality. The presence of these functional groups makes it an invaluable building block in the construction of complex molecules, particularly in the realm of medicinal chemistry and advanced materials.

Recent advancements in synthetic methodologies have further highlighted the versatility of 3-Bromo-2-(2'-chlorobenzyloxy)-5-methylphenylboronic Acid. Researchers have employed this compound as a key intermediate in the synthesis of biologically active molecules, leveraging its reactivity under various coupling reactions. For instance, its boronic acid group enables efficient Suzuki-Miyaura coupling reactions, which are widely used to construct biaryl structures with high precision. This capability has been instrumental in the development of novel drug candidates targeting various therapeutic areas, including cancer and neurodegenerative diseases.

The structural complexity of 3-Bromo-2-(2'-chlorobenzyloxy)-5-methylphenylboronic Acid also makes it an attractive candidate for exploring new synthetic pathways. Recent studies have focused on optimizing its synthesis to enhance yield and purity while minimizing environmental impact. For example, green chemistry approaches, such as using microwave-assisted synthesis or catalytic systems, have been successfully applied to streamline the production process. These innovations not only improve the efficiency of chemical manufacturing but also align with global sustainability goals.

In addition to its role in drug discovery, 3-Bromo-2-(2'-chlorobenzyloxy)-5-methylphenylboronic Acid has found applications in materials science. Its ability to participate in cross-coupling reactions has been exploited in the synthesis of advanced polymers and nanomaterials. For instance, researchers have utilized this compound to create stimuli-responsive polymers that exhibit dynamic properties under external stimuli, such as temperature or pH changes. These materials hold promise for applications in sensors, drug delivery systems, and adaptive coatings.

The growing interest in 3-Bromo-2-(2'-chlorobenzyloxy)-5-methylphenylboronic Acid is also driven by its potential in chemical biology. Its unique structure allows for the exploration of novel bioconjugation strategies, enabling the creation of probes for studying cellular processes at the molecular level. Recent advancements in click chemistry and bioorthogonal reactions have further expanded its utility in this domain.

From an analytical standpoint, the characterization of 3-Bromo-2-(2'-chlorobenzyloxy)-5-methylphenylboronic Acid has benefited from modern spectroscopic techniques. High-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) spectroscopy have provided detailed insights into its molecular structure and purity. These analytical tools are essential for ensuring the quality and consistency of this compound during both research and industrial-scale production.

In conclusion, 3-Bromo-2-(2'-chlorobenzyloxy)-5-methylphenylboronic Acid (CAS No. 849052-17-1) stands as a testament to the ingenuity of modern organic chemistry. Its versatile structure and reactivity continue to drive innovation across multiple disciplines, from drug discovery to materials science. As research progresses, this compound is expected to unlock new possibilities for creating advanced materials and therapeutic agents that address pressing challenges in healthcare and technology.

• 849052-23-9(3-Bromo-2-(4'-chlorobenzyloxy)phenylboronic acid)
• 870777-20-1(2-Benzyloxy-3-bromo-5-methylphenylboronic acid)
• 849052-24-0(3-Bromo-2-(3'-methoxybenzyloxy)phenylboronic acid)
• 1256355-69-7(2-(2,4-dichlorophenylmethoxy)phenylboronic acid)
• 870778-83-9(3-Bromo-2-(3'-chlorobenzyloxy)-5-methylphenylboronic acid)
• 849062-23-3(3-Bromo-5-methyl-2-(3'-methoxybenzyloxy)phenylboronic acid)
• 849052-16-0(3-Bromo-2-(3'-bromobenzyloxy)-5-methylphenylboronic acid)
• 849052-18-2(3-Bromo-2-(4'-chlorobenzyloxy)-5-methylphenylboronic acid)
• 849062-27-7(3-Bromo-2-(3'-bromobenzyloxy)phenylboronic acid)
• 870777-21-2(2-(2'-Chlorobenzyloxy)phenylboronic acid)