Production Method 1

4769-97-5

84807-26-1

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid ,  Sodium cyanoborohydride Solvents: Dichloromethane ;  0 °C; 12 h, rt

Reference

Design, Synthesis, and Structure-Activity Relationships of Indoline-Based Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-Derived 2)-Like 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitors

Zhou, Hai-Shan; Hu, Lv-Bin; Zhang, Han; Shan, Wen-Xin; Wang, Yan; et al, Journal of Medicinal Chemistry, 2020, 63(19), 11149-11168

Production Method 2

52536-99-9

84807-26-1

Reaction Conditions

1.1 Reagents: Iron ,  Hydrochloric acid Solvents: Water

Reference

Synthesis of 2'-deoxyribofuranosyl indole nucleosides related to the antibiotics SF-2140 and neosidomycin

Girgis, Nabih S.; Cottam, Howard B.; Robins, Roland K., Journal of Heterocyclic Chemistry, 1988, 25(2), 361-6

Production Method 3

4769-97-5

84807-26-1

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid ,  Triethylsilane ;  2 h, 50 °C

Reference

Discovery of N-indanyl benzamides as potent RORγt inverse agonists

Tian, Jinlong; Sun, Nannan; Yu, Mingcheng; Gu, Xianfeng ; Xie, Qiong; et al, European Journal of Medicinal Chemistry, 2019, 167, 37-48

Production Method 4

4769-97-5

84807-26-1

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid ,  Triethylsilane ;  0.5 - 3 h, 50 °C
1.2 Reagents: Sodium bicarbonate Solvents: Dichloromethane ,  Water ;  neutralized

Reference

Discovery of Novel N-β-D-Xylosyl-indole Derivatives as Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors for the Management of Hyperglycemia in Diabetes

Yao, Chun-Hsu; Song, Jen-Shin; Chen, Chiung-Tong; Yeh, Teng-Kuang; Hung, Ming-Shiu; et al, Journal of Medicinal Chemistry, 2011, 54(1), 166-178

Production Method 5

52536-99-9

84807-26-1

Reaction Conditions

Reference

Cyclic arylamines

Stevenson, P. J., Science of Synthesis, 2007, 31, 1885-1938

Production Method 6

74795-30-5

84807-26-1

Reaction Conditions

Reference

Indolines

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4-Nitroindoline Raw materials

• 2-(2-chloro-5-nitrophenyl)ethan-1-amine
• 2-(2-chloroethyl)-1,3-dinitrobenzene
• 4-nitro-1H-indole

4-Nitroindoline Preparation Products

• 4-Nitroindoline (84807-26-1)

• 1. Aggregation, pretransitional behavior, and optical properties in the isotropic phase of lyotropic chromonic liquid crystals studied in high magnetic fields
  Tanya Ostapenko,Peter J. Collings,Samuel N. Sprunt,J. T. Gleeson Soft Matter, 2013,9, 9487-9498
• 2. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 3. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 4. An integrated microfluidic 3D tumor system for parallel and high-throughput chemotherapy evaluation?
  Dan Liu,Rui Hu,Zhongchao Huang,Meilin Sun,Kai Han Analyst, 2020,145, 6447-6455
• 5. An investigation of the electrochemical delithiation process of carbon coated α-Fe2O3nanoparticles
  Adrian Brandt,Florian Winter,Sebastian Klamor,Frank Berkemeier,Jatinkumar Rana,Rainer P?ttgen,Andrea Balducci J. Mater. Chem. A, 2013,1, 11229-11236

• 32692-19-6(5-Nitroindoline)
• 165250-68-0(4-Methyl-5-nitroindoline)
• 115210-53-2(2,3-dihydro-1-methyl-6-nitro-1H-Indole)
• 39217-91-9(5-nitro-1,2,3,4-tetrahydroquinoline)
• 936128-69-7(5-methyl-6-nitro-2,3-dihydro-1H-indole)
• 208510-91-2(2,3-dihydro-7-methyl-4-nitro-1H-Indole)
• 19727-83-4(6-Nitroindoline)
• 179898-72-7(3,3-dimethyl-6-nitro-indoline)
• 1000604-16-9(7-methyl-5-nitro-2,3-dihydro-1H-indole)
• 1187929-53-8(6-nitro-2,3-dihydro-1h-indole hydrochloride)