Production Method 1

3828-49-7

847502-81-2

Reaction Conditions

1.1 Reagents: Bromine Catalysts: Iron Solvents: Chloroform ;  rt; overnight, rt

Reference

Discovery of a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR)

Takeuchi, Craig S.; Kim, Byung Gyu; Blazey, Charles M.; Ma, Sunghoon; Johnson, Henry W. B.; et al, Journal of Medicinal Chemistry, 2013, 56(6), 2218-2234

Production Method 2

3828-49-7

847502-81-2

1777807-53-0

928304-47-6

1143502-75-3

Reaction Conditions

1.1 Reagents: Bromine Catalysts: Aluminum chloride Solvents: Dichloromethane ;  rt → < 10 °C; 3 h, < 10 °C; 1 h, 10 °C

Reference

Process Development and Scale-Up of a Benzoxazepine-Containing Kinase Inhibitor

Naganathan, Sriram; Andersen, Denise L.; Andersen, Neil G.; Lau, Stephen; Lohse, Anders; et al, Organic Process Research & Development, 2015, 19(7), 721-734

1-Bromo-3,4-difluoro-2-methylbenzene Raw materials

• 1,2-difluoro-3-methyl-benzene

1-Bromo-3,4-difluoro-2-methylbenzene Preparation Products

• 2,3-Dibromo-5,6-difluorotoluene (1777807-53-0)
• 1-Bromo-3,4-difluoro-2-methylbenzene (847502-81-2)
• 4-Bromo-2,3-difluorotoluene (928304-47-6)
• 5-Bromo-1,2-difluoro-3-methylbenzene (1143502-75-3)

• 1. Aggregation-induced emission enhancement of carbon quantum dots and applications in light emitting devices
  Rongyan Guo,Tao Li,Shuie Shi J. Mater. Chem. C, 2019,7, 5148-5154
• 2. An ionic liquid-mesoporous silica blend as a novel adsorbent for the adsorption and recovery of palladium ions, and its applications in continuous flow study and as an industrial catalyst?
  Shivani Sharma,Chia-Ming Wu,Ranjit T. Koodali,N. Rajesh RSC Adv., 2016,6, 26668-26678
• 3. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 4. An ion-gating multinanochannel system based on a copper-responsive self-cleaving DNAzyme?
  Yang Chen,Di Zhou,Zheyi Meng,Jin Zhai Chem. Commun., 2016,52, 10020-10023
• 5. Aggregation dynamics, structure, and mechanical properties of bigels
  L. Di Michele,D. Fiocco,F. Varrato,E. Eiser,G. Foffi Soft Matter, 2014,10, 3633-3648

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Fluorobenzenes
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

• 14659-58-6(2-bromo-5-fluoro-1,3-dimethyl-benzene)
• 875664-38-3(1-Bromo-4,5-difluoro-2-methylbenzene)
• 16583-13-4(Benzene,1-bromo-2,3,4,5-tetrafluoro-6-methyl-)
• 85233-17-6(Benzene, 1,5-dibromo-3-fluoro-2-methyl-)
• 1580-05-8(2-Bromo-4-fluoro-1,3,5-trimethylbenzene)
• 51760-04-4(1-Bromo-4-fluoro-2,5-dimethylbenzene)
• 52548-00-2(3-Bromo-6-fluoro-o-xylene)
• 1422-54-4(1-bromo-3-fluoro-2-methylbenzene)
• 26584-26-9(Benzene,1-bromo-3-fluoro-2,4-dimethyl-)
• 1143502-75-3(5-Bromo-1,2-difluoro-3-methylbenzene)