Production Method 1

3828-49-7

1777807-53-0

847502-81-2

928304-47-6

1143502-75-3

Reaction Conditions

1.1 Reagents: Bromine Catalysts: Aluminum chloride Solvents: Dichloromethane ;  rt → < 10 °C; 3 h, < 10 °C; 1 h, 10 °C

Reference

Process Development and Scale-Up of a Benzoxazepine-Containing Kinase Inhibitor

Naganathan, Sriram; Andersen, Denise L.; Andersen, Neil G.; Lau, Stephen; Lohse, Anders; et al, Organic Process Research & Development, 2015, 19(7), 721-734

2,3-Dibromo-5,6-difluorotoluene Raw materials

• 1,2-difluoro-3-methyl-benzene

2,3-Dibromo-5,6-difluorotoluene Preparation Products

• 2,3-Dibromo-5,6-difluorotoluene (1777807-53-0)
• 1-Bromo-3,4-difluoro-2-methylbenzene (847502-81-2)
• 4-Bromo-2,3-difluorotoluene (928304-47-6)
• 5-Bromo-1,2-difluoro-3-methylbenzene (1143502-75-3)

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• 5. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182

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