Production Method 1

185259-36-3

84697-13-2

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Diethyl ether ,  Tetrahydrofuran ;  3 h, reflux; reflux → rt
1.2 Reagents: Water ;  rt

Reference

Convenient two-step synthesis of highly functionalized benzo-fused 1,4-diazepin-3-ones and 1,5-diazocin-4-ones by sequential Ugi and intramolecular SNAr reactions

Vezina-Dawod, Simon; Gerber, Nicolas; Liang, Xinxia; Biron, Eric, Tetrahedron, 2017, 73(44), 6347-6355

Production Method 2

185259-36-3

84697-13-2

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Diethyl ether

Reference

Acylguanidines as bioisosteric groups in argininamide-type neuropeptide Y Y1 and Y2 receptor antagonists: synthesis, stability and pharmacological activity

Brennauer, Albert, 2006, , ,

Production Method 3

185259-36-3

84697-13-2

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Diethyl ether ;  3 h, rt; 60 min, reflux; reflux → 0 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ;  0 °C
1.3 Reagents: Potassium bisulfate Solvents: Water ;  pH 2 - 3

Reference

Guanidine-Acylguanidine Bioisosteric Approach in the Design of Radioligands: Synthesis of a Tritium-Labeled NG-Propionylargininamide ([3H]-UR-MK114) as a Highly Potent and Selective Neuropeptide Y Y1 Receptor Antagonist

Keller, Max; Pop, Nathalie; Hutzler, Christoph; Beck-Sickinger, Annette G.; Bernhardt, Guenther; et al, Journal of Medicinal Chemistry, 2008, 51(24), 8168-8172

Production Method 4

696-60-6

84697-13-2

Reaction Conditions

1.1 Reagents: Zinc

Reference

Protection of phenols as t-butyl ethers under mild conditions

Bandgar, B. P.; Kasture, S. P., Journal of Chemical Research, 2000, (5), 252-253

Production Method 5

185259-36-3

84697-13-2

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Tetrahydrofuran ;  0 °C; 10 min, 0 °C; 0 °C → rt; 10 min, rt; 3 h, rt → reflux; reflux → 0 °C
1.2 Reagents: Sodium hydroxide ,  Water

Reference

Ammonium Chloride-Promoted Rapid Synthesis of Monosubstituted Ureas under Microwave Irradiation

Lan, Chunling Blue; Auclair, Karine, European Journal of Organic Chemistry, 2021, 2021(37), 5135-5146

Production Method 6

185259-36-3

84697-13-2

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Tetrahydrofuran ;  30 min, 0 °C; 6 h, 0 °C → reflux; 22 h, reflux → rt; rt → 0 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ;  0 °C

Reference

Discovery of inhibitors for proliferating cell nuclear antigen using a computational-based linked-multiple-fragment screen

Bartolowits, Matthew D.; Gast, Jonathon M.; Hasler, Ashlee J.; Cirrincione, Anthony M.; O'Connor, Rachel J.; et al, ACS Omega, 2019, 4(12), 15181-15196

Production Method 7

696-60-6

84697-13-2

Reaction Conditions

Reference

Product class 2: alkyl aryl ethers - synthesis by substitution

Low, C. M. R., Science of Synthesis, 2007, 31, 547-625

4-(tert-butoxy)phenylmethanamine Raw materials

• 4-Hydroxybenzylamine
• 4-tert-Butoxybenzonitrile

4-(tert-butoxy)phenylmethanamine Preparation Products

• 4-(tert-butoxy)phenylmethanamine (84697-13-2)

• 1. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 2. Alternative donor substrates for inverting and retaining glycosyltransferases?
  Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367
• 3. An ionic liquid-based synergistic extraction strategy for rare earths?
  Yingbo Li,Nada Mehio,Huizhou Liu,Sheng Dai Green Chem., 2015,17, 2981-2993
• 4. Achieving high thermal stability of different rare-earth ions in a single matrix host via the manipulation of the local structure by a solid solution?
  Xiuxia Yang,Lei Zhao,Zhichao Liu,Shuyu Tian,Hao Zhang,Xuhui Xu,Jianbei Qiu,Xue Yu Phys. Chem. Chem. Phys., 2020,22, 16294-16300
• 5. An investigation into the origin of variations in photovoltaic performance using D–D–π–A and D–A–π–A triphenylimidazole dyes with a copper electrolyte?
  Govind Reddy Mol. Syst. Des. Eng., 2021,6, 779-789

• 917911-64-9(Benzenemethanamine,3-(1,1-dimethylethoxy)-a-methyl-, (aR)-)
• 400771-44-0((3-Isopropoxyphenyl)methanamine)
• 6850-60-8(4-Ethoxybenzylamine)
• 738563-98-9(Benzenemethanamine,4-methoxy-3-(1-methylethoxy)-)
• 21244-34-8(1-(4-Isopropoxyphenyl)methanamine)
• 150575-82-9(Benzenemethanamine,4-(1,1-dimethylethoxy)-a-methyl-, (S)- (9CI))
• 917911-63-8(Benzenemethanamine,3-(1,1-dimethylethoxy)-a-methyl-, (aS)-)
• 918812-01-8(Benzenemethanamine, 3-methyl-2-(1-methylethoxy)-)
• 917911-60-5(Benzenemethanamine,4-(1,1-dimethylethoxy)-a-methyl-, (aR)-)
• 887594-84-5(1-(4-tert-butoxybenzyl)hydrazine)