Production Method 1

2179-96-6

1824-81-3

84647-20-1

Reaction Conditions

1.1 Catalysts: Dimethyl sulfoxide ;  15 min

Reference

Triselenium dicyanide (TSD) as a new cyanation reagent. Synthesis of cyano pterins and quinoxalines along with library of cyano N-heterocyclic compounds

Goswami, Shyamaprosad; Maity, Annada C.; Das, Nirmal K.; Sen, Debabrata; Maity, Sibaprasad, Synthetic Communications, 2009, 39(3), 407-415

Production Method 2

155265-57-9

84647-20-1

Reaction Conditions

1.1 Reagents: Ammonia Solvents: Ethanol ;  20 h, 130 °C

Reference

Novel Hepatitis C virus replicon inhibitors: Synthesis and structure-activity relationships of fused pyrimidine derivatives

Chris Krueger, A.; Madigan, Darold L.; Beno, David W.; Betebenner, David A.; Carrick, Robert; et al, Bioorganic & Medicinal Chemistry Letters, 2012, 22(6), 2212-2215

Production Method 3

28900-10-9

84647-20-1

Reaction Conditions

1.1 Reagents: Ammonia Solvents: Ethanol ;  rt → 160 °C; 24 h, 160 °C

Reference

2-Aminonicotinic Acid 1-Oxides Are Chemically Stable Inhibitors of Quinolinic Acid Synthesis in the Mammalian Brain: A Step toward New Antiexcitotoxic Agents

Vallerini, Gian Paolo; Amori, Laura; Beato, Claudia; Tararina, Margarita; Wang, Xiao-Dan; et al, Journal of Medicinal Chemistry, 2013, 56(23), 9482-9495

Production Method 4

28900-10-9

84647-20-1

Reaction Conditions

1.1 Reagents: Ammonia Solvents: Ethanol ;  15 min, rt
1.2 3 d, 200 psi → 120 psi, 180 °C

Reference

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors

Thomas, Allen A.; Le Huerou, Y.; De Meese, J.; Gunawardana, Indrani; Kaplan, Tomas; et al, Bioorganic & Medicinal Chemistry Letters, 2008, 18(6), 2206-2210

Production Method 5

28900-10-9

84647-20-1

Reaction Conditions

1.1 Reagents: Sodium amide

Reference

Synthesis and reactions of polysubstituted 2(1H)-pyridones and pyridines

Hassan, M. A.; Soliman, E. A.; Hamed, A. A., Polish Journal of Chemistry, 1982, 56(2), 419-23

Production Method 6

28900-10-9

84647-20-1

Reaction Conditions

1.1 Reagents: Sodium amide

Reference

Synthesis and reactions of polysubstituted 2(1H)pyridones and pyridines

Hassan, M. A.; Soliman, E. A.; Hamed, A. A., Revue Roumaine de Chimie, 1982, 27(8), 963-7

2-amino-6-methylpyridine-3-carbonitrile Raw materials

• Triselenide, dicyano
• 2-chloro-6-methylpyridine-3-carbonitrile
• 6-methylpyridin-2-amine
• 2-bromo-6-methylpyridine-3-carbonitrile

2-amino-6-methylpyridine-3-carbonitrile Preparation Products

• 2-amino-6-methylpyridine-3-carbonitrile (84647-20-1)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives 3-pyridinecarbonitriles

• 221135-69-9(3-Pyridinecarbonitrile,6-amino-2,5-dimethyl-)
• 129090-35-3([3,4'-Bipyridine]-5-carbonitrile,6-amino-2-methyl-)
• 38076-78-7(2-Amino-5-methylnicotinonitrile)
• 183428-90-2(6-amino-2-methyl-pyridine-3-carbonitrile)
• 21392-51-8(2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile)
• 24517-64-4(2-aminopyridine-3-carbonitrile)
• 5468-34-8(2-amino-4,6-dimethylpyridine-3-carbonitrile)
• 104408-27-7(3-Pyridinecarbonitrile,2-hydrazinyl-6-methyl-)
• 78473-10-6(2-aminopyridine-3,5-dicarbonitrile)
• 62090-40-8(3-Pyridinecarbonitrile, 2-amino-6-(4-methylphenyl)-)