Cas no 84611-43-8 (5-(Benzyloxy)-2-chloropyridine)

5-(Benzyloxy)-2-chloropyridine is a versatile heterocyclic compound used as an intermediate in organic synthesis and pharmaceutical development. Its benzyloxy and chloro substituents enhance reactivity, enabling selective functionalization in cross-coupling reactions and nucleophilic substitutions. The compound exhibits stability under standard conditions, making it suitable for diverse applications in medicinal chemistry and material science.
5-(Benzyloxy)-2-chloropyridine structure
84611-43-8 structure
Product Name:5-(Benzyloxy)-2-chloropyridine
CAS No:84611-43-8
MF:C12H10ClNO
MW:219.666902065277
MDL:MFCD11976457
CID:666683
PubChem ID:10013717
Update Time:2025-06-19

5-(Benzyloxy)-2-chloropyridine Chemical and Physical Properties

Names and Identifiers

    • 5-(Benzyloxy)-2-chloropyridine
    • 2-Chloro-5-benzyloxypyridine
    • 2-chloro-5-phenylmethoxypyridine
    • Pyridine, 2-chloro-5-(phenylmethoxy)-
    • 2-Chloro-5-(phenylmethoxy)pyridine (ACI)
    • MFCD11976457
    • SCHEMBL940824
    • AS-60258
    • CS-0036416
    • 5-benzyloxy-2-chloropyridine
    • W12725
    • AKOS017565607
    • DTXSID60434180
    • 84611-43-8
    • DB-049772
    • 5-benzyloxy-2-chloro-pyridine
    • QLUMNDLJGBUHPB-UHFFFAOYSA-N
    • MDL： MFCD11976457
    • Inchi： 1S/C12H10ClNO/c13-12-7-6-11(8-14-12)15-9-10-4-2-1-3-5-10/h1-8H,9H2
    • InChI Key： QLUMNDLJGBUHPB-UHFFFAOYSA-N
    • SMILES： ClC1C=CC(OCC2C=CC=CC=2)=CN=1

Computed Properties

  • Exact Mass: 219.0450916g/mol
  • Monoisotopic Mass: 219.0450916g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 15
  • Rotatable Bond Count: 3
  • Complexity: 183
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.3
  • Topological Polar Surface Area: 22.1?2

Experimental Properties

  • Density: 1.225

5-(Benzyloxy)-2-chloropyridine Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
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5-(Benzyloxy)-2-chloropyridine Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Cesium carbonate Catalysts: 1,10-Phenanthroline ,  Cuprous iodide Solvents: Toluene ;  24 h, 110 °C
Reference
A Simple Cu-Catalyzed Coupling Approach to Substituted 3-Pyridinol and 5-Pyrimidinol Antioxidants
Nara, Susheel J.; Jha, Mukund; Brinkhorst, Johan; Zemanek, Tony J.; Pratt, Derek A., Journal of Organic Chemistry, 2008, 73(23), 9326-9333

Production Method 2

Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  25 °C; 4 h, 25 °C
1.2 Solvents: Water ;  25 °C
Reference
In the Quest for Potent and Selective Malic Enzyme 3 Inhibitors for the Treatment of Pancreatic Ductal Adenocarcinoma
Sheth, Gaurav; Shah, Shailesh R. ; Sengupta, Prabal; Jarag, Tushar; Chimanwala, Sabbirhusen; et al, ACS Medicinal Chemistry Letters, 2023, 14(1), 41-50

5-(Benzyloxy)-2-chloropyridine Raw materials

5-(Benzyloxy)-2-chloropyridine Preparation Products

5-(Benzyloxy)-2-chloropyridine Related Literature

84611-43-8 (5-(Benzyloxy)-2-chloropyridine) Related Products

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