Production Method 1

84647-20-1

846021-26-9

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Water ;  rt → reflux; 3 h, reflux; reflux → 0 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 4 - 5, 0 °C

Reference

2-Aminonicotinic Acid 1-Oxides Are Chemically Stable Inhibitors of Quinolinic Acid Synthesis in the Mammalian Brain: A Step toward New Antiexcitotoxic Agents

Vallerini, Gian Paolo; Amori, Laura; Beato, Claudia; Tararina, Margarita; Wang, Xiao-Dan; et al, Journal of Medicinal Chemistry, 2013, 56(23), 9482-9495

Production Method 2

84647-20-1

846021-26-9

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Water ;  2 h, 110 °C

Reference

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors

Thomas, Allen A.; Le Huerou, Y.; De Meese, J.; Gunawardana, Indrani; Kaplan, Tomas; et al, Bioorganic & Medicinal Chemistry Letters, 2008, 18(6), 2206-2210

2-amino-6-methyl-pyridine-3-carboxylic acid Raw materials

• 2-amino-6-methylpyridine-3-carbonitrile

2-amino-6-methyl-pyridine-3-carboxylic acid Preparation Products

• 2-amino-6-methyl-pyridine-3-carboxylic acid (846021-26-9)

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• 5345-47-1(2-aminopyridine-3-carboxylic acid)
• 532440-94-1(2-Amino-5-methylnicotinic acid)
• 84596-20-3(3-Pyridinecarboxylic acid, 2-amino-6-methyl-5-phenyl-)
• 175155-53-0(2,6-diamino-3-Pyridinecarboxylic acid)
• 89795-70-0(2-aminopyridine-3,5-dicarboxylic acid)
• 680208-82-6(6-Amino-2-methylnicotinic acid)
• 89977-05-9(3,4-Pyridinedicarboxylicacid, 2-amino-6-methyl-)
• 106837-89-2(2-amino-4,6-dimethylpyridine-3-carboxylic acid)
• 70959-85-2(2-amino-6-methyl-3-Pyridinecarboxylic acid ethyl ester)
• 52834-01-2(2-amino-4,6-dimethyl-3-pyridinecarboxylicacid hydrochloride)