Production Method 1

41602-56-6

84562-48-1

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  8 h, 23 °C → 50 °C

Reference

Self-immolative hydroxybenzylamine linkers for traceless protein modification

Rose, Douglas A.; et al, Journal of the American Chemical Society, 2022, 144(13), 6050-6058

Production Method 2

15799-79-8

84562-48-1

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride

Reference

N2-(4-Substituted-2,6-dichlorophenyl)-N1,N1-dimethylformamidines as antihypertensive and diuretic agents

Meyer, Walter E.; et al, Journal of Medicinal Chemistry, 1984, 27(12), 1705-10

Production Method 3

450-83-9

84562-48-1

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  30 min, rt; rt → 90 °C; 15 h, 90 °C

Reference

Convergent 18F-labeling and evaluation of N-benzyl-phenethylamines as 5-HT2A receptor PET ligands

Petersen, Ida Nymann; et al, Bioorganic & Medicinal Chemistry, 2016, 24(21), 5353-5356

Production Method 4

41602-56-6

84562-48-1

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  8 h, 50 °C

Reference

Effect of phenyl ring substitution on J-aggregate formation ability of novel bisazomethine dyes in vapour-deposited films

Kim, Byung-Soon; et al, Dyes and Pigments, 2011, 90(1), 56-64

Production Method 5

15799-79-8

84562-48-1

Reaction Conditions

1.1 Reagents: 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone ,  Cesium carbonate ,  Water Solvents: Toluene ;  8 h, 40 °C

Reference

Oxidation-Induced para-Selective Formylation of N,N-Substituted Aniline

Sun, Li; et al, Asian Journal of Organic Chemistry, 2018, 7(8), 1571-1574

Production Method 6

99-07-0

84562-48-1

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride Solvents: Dimethylformamide ;  0 °C; 16 h, 80 °C; 80 °C → rt
1.2 Reagents: Sodium hydroxide Solvents: Water ;  neutralized, cooled
2.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  8 h, 50 °C

Reference

Effect of phenyl ring substitution on J-aggregate formation ability of novel bisazomethine dyes in vapour-deposited films

Kim, Byung-Soon; et al, Dyes and Pigments, 2011, 90(1), 56-64

4-Dimethylamino-2-methoxybenzaldehyde Raw materials

• N,N-Dimethyl-m-anisidine
• 4-Fluoro-2-methoxybenzaldehyde
• 3-(Dimethylamlno)phenol
• 4-(Dimethylamino)-2-hydroxybenzaldehyde

4-Dimethylamino-2-methoxybenzaldehyde Preparation Products

• 4-Dimethylamino-2-methoxybenzaldehyde (84562-48-1)

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