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  Ying Shi,Yan-Ran Wu,Ming-Bo Su,Dong-Hao Shen,Hendra Gunosewoyo,Fan Yang,Jia Li,Jie Tang,Yu-Bo Zhou,Li-Fang Yu RSC Adv. 2018 8 1666
• 2. CCXIII.—The Reimer–Tiemann reaction with m-fluorophenol and the nitration of 4-fluoro-2-hydroxy- and 2-fluoro-4-hydroxy-benzaldehydes
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• 3. A novel mitochondria-targeted ratiometric fluorescent probe for endogenous sulfur dioxide derivatives as a cancer-detecting tool
  Di Yang,Xiao-Ying He,Xiao-Tian Wu,Hao-Nan Shi,Jun-Ying Miao,Bao-Xiang Zhao,Zhao-Min Lin J. Mater. Chem. B 2020 8 5722
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoyl derivatives
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone

4-Fluoro-2-methoxybenzaldehyde (CAS No. 450-83-9): Properties, Applications, and Market Insights

4-Fluoro-2-methoxybenzaldehyde (CAS No. 450-83-9) is a specialized aromatic aldehyde with significant applications in pharmaceutical and agrochemical synthesis. This compound, characterized by its fluoro and methoxy functional groups, has garnered attention due to its unique reactivity and versatility in organic transformations. In recent years, the demand for fluorinated benzaldehyde derivatives has surged, driven by their role in drug discovery and material science.

The molecular structure of 4-Fluoro-2-methoxybenzaldehyde features a benzene ring substituted with a formyl group at position 1, a fluoro substituent at position 4, and a methoxy group at position 2. This arrangement imparts distinct electronic and steric properties, making it a valuable intermediate in the synthesis of bioactive molecules. Researchers often explore its reactivity in cross-coupling reactions and nucleophilic substitutions, which are pivotal in modern medicinal chemistry.

One of the most prominent applications of 4-Fluoro-2-methoxybenzaldehyde is in the development of pharmaceutical intermediates. Its incorporation into drug candidates enhances metabolic stability and bioavailability, addressing key challenges in drug design. Recent studies highlight its utility in synthesizing anticancer agents and CNS-targeting compounds, aligning with the growing focus on precision medicine. Additionally, its role in flavor and fragrance formulations underscores its versatility beyond pharmaceuticals.

The market dynamics for 4-Fluoro-2-methoxybenzaldehyde reflect broader trends in fine chemicals and custom synthesis. With increasing investments in green chemistry, manufacturers are adopting sustainable production methods, such as catalytic fluorination and solvent-free processes. This shift resonates with the global emphasis on environmentally friendly synthesis, a topic frequently searched in academic and industrial circles.

Analytical characterization of 4-Fluoro-2-methoxybenzaldehyde typically involves techniques like HPLC, GC-MS, and NMR spectroscopy. These methods ensure high purity, which is critical for its end-use applications. Quality control protocols often emphasize the absence of impurities and isomeric byproducts, as these can impact downstream reactions. Regulatory compliance, particularly in pharmaceutical applications, further underscores the need for stringent analytical standards.

In the context of research trends, 4-Fluoro-2-methoxybenzaldehyde has been featured in studies exploring structure-activity relationships (SAR) and molecular docking. These investigations are particularly relevant to the development of targeted therapies, a hot topic in biomedical research. The compound’s ability to serve as a scaffold for drug design makes it a subject of ongoing interest in academic publications and patent filings.

From a commercial perspective, suppliers of 4-Fluoro-2-methoxybenzaldehyde often highlight its availability in varying pack sizes and custom purity grades. This flexibility caters to diverse customer needs, ranging from small-scale research laboratories to large-scale industrial producers. Pricing trends are influenced by factors such as raw material costs, production scalability, and regional demand fluctuations.

Looking ahead, the future of 4-Fluoro-2-methoxybenzaldehyde appears promising, with potential expansions into advanced material science and electronic chemicals. Innovations in heterocyclic chemistry and catalysis may further unlock its utility, positioning it as a cornerstone in synthetic organic chemistry. As the scientific community continues to explore its applications, this compound is poised to remain a focal point in both research and industry.

• 19415-51-1(5-Fluoro-2-methoxybenzaldehyde)
• 146137-74-8(2-Fluoro-6-methoxybenzaldehyde)
• 1096786-38-7(5-fluoro-2-(4-methylphenoxy)benzaldehyde)
• 320423-61-8(2-(4-Fluorophenoxy)benzaldehyde)
• 887267-45-0(4-Fluoro-2-phenoxybenzaldehyde)
• 145742-34-3(4,5-Difluoro-2-methoxybenzaldehyde)
• 170482-99-2(Benzaldehyde, 3-fluoro-2-hydroxy-6-methoxy-)
• 139008-21-2(Benzaldehyde, 4-fluoro-2-methoxy-5-methyl-)
• 883537-24-4(2-Ethoxy-4-fluorobenzaldehyde)
• 139549-11-4(Benzaldehyde, 4-fluoro-2,6-dimethoxy-)