Production Method 1

25016-20-0

84547-86-4

Reaction Conditions

1.1 Reagents: Bromine

Reference

Dimethylpyrazole-based syntheses. V. Nitration of 4-halopyrazole-3- and 5-carboxylic acids

Manaev, Yu. A.; et al, Zhurnal Obshchei Khimii, 1982, 52(11), 2592-8

Production Method 2

211738-66-8

84547-86-4

Reaction Conditions

1.1 Reagents: Lithium hydroxide Solvents: Methanol ,  Water

Reference

The synthesis of a new pyrazolylimidazolinone via 1,3-dipolar cycloaddition reaction of N-methyl sydnone with methyl propiolate

Jeon, Dong Ju; et al, Bulletin of the Korean Chemical Society, 1998, 19(7), 725-726

Production Method 3

5775-82-6

84547-86-4

Reaction Conditions

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1)

Reference

Dimethylpyrazole-based syntheses. V. Nitration of 4-halopyrazole-3- and 5-carboxylic acids

Manaev, Yu. A.; et al, Zhurnal Obshchei Khimii, 1982, 52(11), 2592-8

Production Method 4

17827-61-1

84547-86-4

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Chloroform
2.1 Reagents: Lithium hydroxide Solvents: Methanol ,  Water

Reference

The synthesis of a new pyrazolylimidazolinone via 1,3-dipolar cycloaddition reaction of N-methyl sydnone with methyl propiolate

Jeon, Dong Ju; et al, Bulletin of the Korean Chemical Society, 1998, 19(7), 725-726

Production Method 5

694-48-4

84547-86-4

Reaction Conditions

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1)
2.1 Reagents: Bromine

Reference

Dimethylpyrazole-based syntheses. V. Nitration of 4-halopyrazole-3- and 5-carboxylic acids

Manaev, Yu. A.; et al, Zhurnal Obshchei Khimii, 1982, 52(11), 2592-8

Production Method 6

6939-12-4

922-67-8

84547-86-4

Reaction Conditions

1.1 Solvents: Toluene
2.1 Reagents: N-Bromosuccinimide Solvents: Chloroform
3.1 Reagents: Lithium hydroxide Solvents: Methanol ,  Water

Reference

The synthesis of a new pyrazolylimidazolinone via 1,3-dipolar cycloaddition reaction of N-methyl sydnone with methyl propiolate

Jeon, Dong Ju; et al, Bulletin of the Korean Chemical Society, 1998, 19(7), 725-726

Production Method 7

84547-86-4

84547-86-4

25016-20-0

Reaction Conditions

1.1 Solvents: Acetonitrile ,  Water ;  overnight, pH 9.5, rt
1.2 Reagents: Ethanol
1.3 Reagents: Molybdenum hexacarbonyl ,  Cesium hydroxide Catalysts: Palladate(1-), [2′-(amino-κN)[1,1′-biphenyl]-2-yl-κC]chloro[2′-(dicyclohexylphos… Solvents: 1-Methoxy-2-propanol ,  Water ;  15 h, 80 °C

Reference

Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis

Li, Jian-Yuan; et al, Bioconjugate Chemistry, 2019, 30(8), 2209-2215

4-Bromo-1-methyl-1H-pyrazole-3-carboxylic acid Raw materials

• Methyl 1-methyl-1H-pyrazole-3-carboxylate
• sydnone, 3-methyl-
• 1,3-Dimethylpyrazole
• 4-Bromo-1-methyl-1H-pyrazole-3-carboxylic acid
• methyl 4-bromo-1-methyl-pyrazole-3-carboxylate
• 1-Methyl-1H-pyrazole-3-carboxylic acid
• methyl prop-2-ynoate
• 4-Bromo-1,3-dimethyl-1H-pyrazole

4-Bromo-1-methyl-1H-pyrazole-3-carboxylic acid Preparation Products

• 4-Bromo-1-methyl-1H-pyrazole-3-carboxylic acid (84547-86-4)
• 1-Methyl-1H-pyrazole-3-carboxylic acid (25016-20-0)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazole carboxylic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazoles Pyrazole carboxylic acids and derivatives

• 287917-96-8(4-bromo-1-methyl-pyrazole-3-carbaldehyde)
• 915707-65-2((4-Bromo-1-methyl-1H-pyrazol-3-yl)methanol)
• 400877-53-4(ethyl 4-bromo-1-methyl-pyrazole-3-carboxylate)
• 5775-91-7(4-bromo-1,5-dimethyl-pyrazole-3-carboxylic acid)
• 128537-48-4(4-Bromo-3-ethyl-1-methyl-1H-pyrazole-5-carboxylic acid)
• 514816-42-3(Methyl 4-bromo-1-methyl-1H-pyrazole-5-carboxylate)
• 211738-66-8(methyl 4-bromo-1-methyl-pyrazole-3-carboxylate)
• 175276-99-0(4-Bromo-1-ethyl-3-methyl-1H-pyrazole-5-carboxylic acid)
• 5775-88-2(4-Bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic Acid)
• 84547-84-2(4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid)