Production Method 1

694-31-5

84547-84-2

Reaction Conditions

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1)
2.1 Reagents: Bromine

Reference

Dimethylpyrazole-based syntheses. V. Nitration of 4-halopyrazole-3- and 5-carboxylic acids

Manaev, Yu. A.; et al, Zhurnal Obshchei Khimii, 1982, 52(11), 2592-8

Production Method 2

16034-46-1

84547-84-2

Reaction Conditions

1.1 Reagents: Sodium bromide Solvents: Chloroform ,  Water ;  30 °C

Reference

The Reactivity Trends in Electrochemical Chlorination and Bromination of N-Substituted and N-Unsubstituted Pyrazoles*

Lyalin, B. V.; et al, Chemistry of Heterocyclic Compounds (New York, 2014, 49(11), 1599-1610

Production Method 3

16034-46-1

84547-84-2

Reaction Conditions

1.1 Reagents: Bromine

Reference

Dimethylpyrazole-based syntheses. V. Nitration of 4-halopyrazole-3- and 5-carboxylic acids

Manaev, Yu. A.; et al, Zhurnal Obshchei Khimii, 1982, 52(11), 2592-8

Production Method 4

5775-86-0

84547-84-2

Reaction Conditions

1.1 Reagents: Permanganic acid (HMnO4), potassium salt (1:1)

Reference

Dimethylpyrazole-based syntheses. V. Nitration of 4-halopyrazole-3- and 5-carboxylic acids

Manaev, Yu. A.; et al, Zhurnal Obshchei Khimii, 1982, 52(11), 2592-8

4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid Raw materials

• 1-Methyl-1H-pyrazole-5-carboxylic acid
• 4-Bromo-1,5-dimethyl-1H-pyrazole
• 1,5-Dimethylpyrazole

4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid Preparation Products

• 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid (84547-84-2)

• 1. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 2. An alkynylboronatecycloaddition strategy to functionalised benzyne derivatives?
  James D. Kirkham,Patrick M. Delaney,George J. Ellames,Eleanor C. Row,Joseph P. A. Harrity Chem. Commun., 2010,46, 5154-5156
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  Xin Fu,Qing-rong Liang,Rong-guang Luo,Yan-shu Li,Xiao-ping Xiao,Lu-lu Yu,Wen-zhe Shan,Guang-qin Fan J. Mater. Chem. B, 2019,7, 3088-3099
• 4. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126
• 5. An amorphous Cu–In–S nanoparticle-based precursor ink with improved atom economy for CuInSe2 solar cells with 10.85% efficiency?
  Green Chem., 2017,19, 1268-1277

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazole carboxylic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazoles Pyrazole carboxylic acids and derivatives

Comprehensive Overview of 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid (CAS No. 84547-84-2)

4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid (CAS No. 84547-84-2) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This brominated pyrazole derivative is widely recognized for its role as a key intermediate in the synthesis of bioactive molecules. Researchers and industry professionals frequently search for 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid suppliers, synthesis methods, and applications in drug discovery, making it a compound of high relevance in modern chemistry.

The molecular structure of 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid features a pyrazole ring substituted with a bromine atom at the 4-position and a carboxylic acid group at the 5-position. This unique arrangement contributes to its reactivity and utility in various chemical transformations. The compound's CAS number 84547-84-2 serves as a critical identifier in chemical databases, ensuring accurate referencing in scientific literature and regulatory documents.

In recent years, the demand for pyrazole-based compounds has surged due to their diverse pharmacological properties. 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid is particularly valuable in the development of kinase inhibitors, which are pivotal in targeted cancer therapies. This aligns with current trends in precision medicine and personalized treatment approaches, topics that dominate discussions in medical research circles.

The compound's applications extend beyond pharmaceuticals. In agrochemical research, 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid serves as a building block for novel pesticides and herbicides. With increasing global focus on sustainable agriculture and crop protection solutions, this compound has become a subject of intense study. Researchers often investigate its potential in creating environmentally friendly alternatives to traditional agrochemicals.

From a synthetic chemistry perspective, 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid offers multiple reactive sites for further functionalization. The bromine atom facilitates various cross-coupling reactions, while the carboxylic acid group enables condensation and esterification processes. These characteristics make it a versatile intermediate in organic synthesis, particularly in the construction of complex heterocyclic systems.

Quality control and characterization of 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid typically involve advanced analytical techniques. High-performance liquid chromatography (HPLC), nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry are commonly employed to verify purity and structural integrity. These analytical methods are crucial for ensuring the compound meets the stringent requirements of pharmaceutical applications.

The market for 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid has shown steady growth, driven by increasing research activities in medicinal chemistry. Suppliers and manufacturers are expanding their production capacities to meet the rising demand from academic institutions and pharmaceutical companies. Current market analyses indicate particular interest from regions with strong biotechnology sectors, including North America, Europe, and parts of Asia.

Storage and handling of 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid require standard laboratory precautions. The compound should be kept in a cool, dry environment, protected from light and moisture. While not classified as hazardous under normal conditions, proper personal protective equipment is recommended when working with this chemical, in line with general laboratory safety protocols.

Future research directions for 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid may explore its potential in emerging therapeutic areas. With growing interest in small molecule therapeutics and targeted drug delivery systems, this compound could play a significant role in developing next-generation pharmaceuticals. Additionally, its application in materials science, particularly in the design of functional organic materials, represents an exciting avenue for investigation.

For researchers seeking 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid CAS 84547-84-2, it's essential to source the compound from reputable suppliers who provide comprehensive analytical data. The quality of the starting material can significantly impact the outcomes of synthetic pathways and subsequent biological testing. Many suppliers now offer custom synthesis services and bulk quantities to accommodate diverse research needs.

In conclusion, 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid represents an important building block in modern chemical research. Its versatility in pharmaceutical and agrochemical applications, combined with its synthetic accessibility, ensures its continued relevance in scientific investigations. As research trends evolve toward more targeted and sustainable solutions, this compound is likely to maintain its position as a valuable tool for chemists and researchers worldwide.

• 5775-89-3(Ethyl 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylate)
• 5775-91-7(4-bromo-1,5-dimethyl-pyrazole-3-carboxylic acid)
• 128537-48-4(4-Bromo-3-ethyl-1-methyl-1H-pyrazole-5-carboxylic acid)
• 660408-08-2(Methyl 4-Bromo-1,3-dimethyl-1H-pyrazole-5-carboxylate)
• 84547-86-4(4-Bromo-1-methyl-1H-pyrazole-3-carboxylic acid)
• 514816-42-3(Methyl 4-bromo-1-methyl-1H-pyrazole-5-carboxylate)
• 175276-99-0(4-Bromo-1-ethyl-3-methyl-1H-pyrazole-5-carboxylic acid)
• 5775-88-2(4-Bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic Acid)
• 514800-97-6(4-Bromo-1-ethyl-1H-pyrazole-5-carboxylic acid)
• 1328640-39-6(ethyl 4-bromo-1-methyl-1H-pyrazole-5-carboxylate)