Production Method 1

188847-59-8

84501-64-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  overnight, rt

Reference

Piperazine additions to C60 - a facile approach to fullerene substitution

Butts, Craig P.; et al, Organic & Biomolecular Chemistry, 2005, 3(7), 1209-1216

Production Method 2

98-96-4

84501-64-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Platinum dioxide Solvents: Ethanol ,  Acetic acid

Reference

Tetrazole amino acids as competitive NMDA antagonists

Ornstein, Paul L.; et al, Bioorganic & Medicinal Chemistry Letters, 1993, 3(1), 43-8

Production Method 3

140-28-3

15102-42-8

84501-64-4

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Toluene ;  80 °C; 48 h, reflux
2.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  overnight, rt

Reference

Piperazine additions to C60 - a facile approach to fullerene substitution

Butts, Craig P.; et al, Organic & Biomolecular Chemistry, 2005, 3(7), 1209-1216

Production Method 4

19847-12-2

84501-64-4

Reaction Conditions

1.1 Solvents: Ethanol ,  Water ;  20 min, 100 °C
2.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ,  Water ;  100 °C

Reference

Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

Ingham, Richard J.; et al, Beilstein Journal of Organic Chemistry, 2014, 10, 641-652

Production Method 5

187589-36-2

84501-64-4

Reaction Conditions

1.1 Reagents: Manganese carbonate ,  Ammonium nitrate Solvents: Chlorobenzene ;  5 h, reflux

Reference

Selective and efficient heterogeneous hydration of nitriles to amides using silica supported manganese dioxide

Khadilkar, Bhushan M.; et al, Indian Journal of Chemistry, 2003, (11), 2814-2819

Production Method 6

187589-36-2

84501-64-4

Reaction Conditions

1.1 Reagents: Manganese oxide (MnO2) ,  Silica

Reference

Totally selective dry microwave assisted amide synthesis by hydration of nitrile using silica supported MnO2 reagent

Khadilkar, Bhushan M.; et al, Synthetic Communications, 2002, 32(11), 1731-1734

Production Method 7

188847-59-8

84501-64-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  overnight, rt

Reference

The preparation and structures of non-hydrocarbon functionalized fullerene-diamine adducts

Butts, Craig P.; et al, Chemical Communications (Cambridge, 2003, (13), 1530-1531

Production Method 8

98-96-4

84501-64-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ,  Water ;  100 °C

Reference

Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

Ingham, Richard J.; et al, Beilstein Journal of Organic Chemistry, 2014, 10, 641-652

Production Method 9

98-96-4

84501-64-4

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  5 h, 20 bar, 85 °C

Reference

Preparation of (S)-piperazine-2-carboxylic acid, (R)-piperazine-2-carboxylic acid, and (S)-piperidine-2-carboxylic acid by kinetic resolution of the corresponding racemic carboxamides with stereoselective amidases in whole bacterial cells

Eichhorn, Eric; et al, Tetrahedron: Asymmetry, 1997, 8(15), 2533-2536

Production Method 10

140-28-3

15102-42-8

84501-64-4

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Toluene ;  48 h, 80 °C; 80 °C → rt
2.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  overnight, rt

Reference

The preparation and structures of non-hydrocarbon functionalized fullerene-diamine adducts

Butts, Craig P.; et al, Chemical Communications (Cambridge, 2003, (13), 1530-1531

Piperazine-2-carboxamide Raw materials

• 2-Piperazinecarboxamide, 1,4-bis(phenylmethyl)-
• Piperazine-2-carbonitrile
• pyrazine-2-carbonitrile
• Pyrazinamide
• N,N'-Dibenzylethylenediamine
• 2,3-Dibromopropionamide

Piperazine-2-carboxamide Preparation Products

• Piperazine-2-carboxamide (84501-64-4)

• 1. Alternative donor substrates for inverting and retaining glycosyltransferases?
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• 5. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

• 646523-34-4(2-Piperazinecarboxamide,N-propyl-)
• 166941-47-5(SpS)-piperazine-t-butyl-carboxamide)
• 166941-51-1((S)-(-)-2-T-BUTYL-2-PIPERAZINECARBOXAMIDE)
• 138681-31-9((2R)-piperazine-2-carboxamide)
• 220364-87-4(1,4-Diazepane-2-carboxamide)
• 121885-09-4(N-(tert-Butyl)piperazine-2-carboxamide)
• 99357-33-2(2-Piperazinecarboxamide,N-methyl-3,6-dioxo-)
• 88100-27-0(Propanediamide, 2-(ethylamino)-)
• 159572-93-7((2S)-piperazine-2-carboxamide)
• 56904-18-8(4-methyl-2-Piperazinecarboxamide)