Cas no 84467-54-9 (Didesmethyl Sibutramine)

Didesmethyl Sibutramine structure
Didesmethyl Sibutramine structure
Product Name:Didesmethyl Sibutramine
CAS No:84467-54-9
MF:C15H22ClN
MW:251.79488325119
MDL:MFCD06658940
CID:720228
PubChem ID:134772
Update Time:2024-10-26

Didesmethyl Sibutramine Chemical and Physical Properties

Names and Identifiers

    • 1-(1-(4-Chlorophenyl)cyclobutyl)-3-methylbutan-1-amine
    • Didesmethyl Sibutramine
    • 1-[1-(4-Chlorophenyl)]-Alpha-(2-Methylpropyl) Cyclobutane Methanamine
    • 1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutan-1-amine
    • Cyclobutanemethanamine,1-(4-chlorophenyl)-a-(2-methylpropyl)-
    • Didemethylsibutramine
    • N-Didemethylsibutramine
    • N-Didesmethylsibutramine
    • 1-(4-Chlorophenyl)-α-(2-methylpropyl)cyclobutanemethanamine (ACI)
    • (±)-Didesmethylsibutramine
    • 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine
    • Cyclobutanemethanamine, 1-(4-chlorophenyl)-a-(2-methylpropyl)-
    • SCHEMBL2378931
    • CYCLOBUTANEMETHANAMINE, 1-(4-CHLOROPHENYL)-.ALPHA.-(2-METHYLPROPYL)-
    • SY225628
    • (1-(4-Chlorophenyl)cyclobutyl)-3-methylbutylamine
    • 987R943R3P
    • NSC_134771
    • 1-(1-(4-CHLOROPHENYL)CYCLOBUTYL)-3-METHYLBUTYLAMINE
    • AC6907
    • UNII-987R943R3P
    • NS00007524
    • BDBM84743
    • MFCD06658940
    • 1-[1-(4-Chloropyenyl)cyclobutyl]-3-methylbutylamine
    • (-)-N,N-Didesmethylsibutramine
    • CS-0456114
    • Q27272099
    • 1-[1-(4-Chloroprenyl)cyclobutyl]-3-Methylbutylamine
    • N-DIDESMETHYLSIBUTRAMINE [WHO-DD]
    • AS-79118
    • 84467-54-9
    • N-BIS-DESMETHYL-SIBUTRAMINE
    • 1-(1-(4-CHLOROPHENYL)-2,2,3,3,4,4-HEXADEUTERIOCYCLOBUTYL)-3-METHYLBUTAN-1-AMINE
    • SCHEMBL682189
    • CHEMBL1625728
    • BRD-A68304895-003-02-2
    • AKOS015962045
    • DTXSID801004734
    • didesmethylsibutramine
    • (+/-)-Didesmethylsibutramine
    • Racemic 1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine
    • 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methyl-1-butylamine
    • WQSACWZKKZPCHN-UHFFFAOYSA-N
    • CAS_134771
    • MDL： MFCD06658940
    • Inchi： 1S/C15H22ClN/c1-11(2)10-14(17)15(8-3-9-15)12-4-6-13(16)7-5-12/h4-7,11,14H,3,8-10,17H2,1-2H3
    • InChI Key： WQSACWZKKZPCHN-UHFFFAOYSA-N
    • SMILES： ClC1C=CC(C2(CCC2)C(CC(C)C)N)=CC=1

Computed Properties

  • Exact Mass: 251.14400
  • Monoisotopic Mass: 251.1440774g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 17
  • Rotatable Bond Count: 4
  • Complexity: 239
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 4.5
  • Topological Polar Surface Area: 26?2

Experimental Properties

  • PSA: 26.02000
  • LogP: 4.83540

Didesmethyl Sibutramine Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
Chemenu
CM109767-1g
1-(1-(4-Chlorophenyl)cyclobutyl)-3-methylbutan-1-amine
 84467-54-9 95%
1g
 $830 2021-06-15
Alichem
A019120510-1g
1-(1-(4-Chlorophenyl)cyclobutyl)-3-methylbutan-1-amine
 84467-54-9 95%
1g
 $756.84 2023-08-31
SHANG HAI SHAO YUAN SHI JI Co., Ltd.
SY225628-0.25g
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methyl-1-butylamine
 84467-54-9 ≥95%
0.25g
 ￥3500.00 2025-04-12
SHANG HAI SHAO YUAN SHI JI Co., Ltd.
SY225628-1g
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methyl-1-butylamine
 84467-54-9 ≥95%
1g
 ￥9000.00 2025-04-12
SHANG HAI SHAO YUAN SHI JI Co., Ltd.
SY225628-5g
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methyl-1-butylamine
 84467-54-9 ≥95%
5g
 ￥15000.00 2025-04-12
Chemenu
CM109767-1g
1-(1-(4-Chlorophenyl)cyclobutyl)-3-methylbutan-1-amine
 84467-54-9 95%
1g
 $830 2023-03-07
eNovation Chemicals LLC
D918474-0.25g
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methyl-1-butylamine
 84467-54-9 95%
0.25g
 $385 2024-07-20
eNovation Chemicals LLC
D918474-1g
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methyl-1-butylamine
 84467-54-9 95%
1g
 $990 2024-07-20
eNovation Chemicals LLC
D918474-5g
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methyl-1-butylamine
 84467-54-9 95%
5g
 $1650 2024-07-20
eNovation Chemicals LLC
Y1050319-250mg
Cyclobutanemethanamine, 1-(4-chlorophenyl)-a-(2-methylpropyl)-
 84467-54-9 95%
250mg
 $650 2023-05-17

Didesmethyl Sibutramine Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Hydrochloric acid Solvents: Diglyme ,  Water ;  18 h, reflux
1.2 Reagents: Sodium hydroxide Solvents: Water ;  basified
Reference
A Study and Identification of Potential By-Products of Sibutramine
Reddy, G. Om; et al, Organic Process Research & Development, 1999, 3(6), 488-492

Production Method 2

Reaction Conditions
1.1 Reagents: Magnesium Solvents: Diethyl ether ,  Toluene
1.2 Reagents: Potassium borohydride Solvents: Isopropanol
Reference
Synthesis of sibutramine hydrochloride
Li, Jiaming; et al, Huaxi Yaoxue Zazhi, 2001, 16(2), 114-115

Production Method 3

Reaction Conditions
1.1 Reagents: Magnesium Catalysts: Iodine Solvents: Tetrahydrofuran ;  rt; 65 °C
1.2 Solvents: Toluene ;  65 °C; 12 h, 90 - 95 °C
1.3 Reagents: Potassium borohydride Solvents: Isopropanol ;  rt; 12 h, 90 - 95 °C
1.4 Solvents: Water ;  30 min, rt
Reference
Syntheses, characterizations and crystal structures of the Schiff bases derived from 1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine
Pen, Zhenshan; et al, Huaxue Tongbao, 2009, 72(9), 820-827

Production Method 4

Reaction Conditions
1.1 Solvents: Methanol
2.1 Reagents: Potassium hydroxide Solvents: Acetonitrile
3.1 Reagents: Magnesium Solvents: Tetrahydrofuran
3.2 Reagents: Potassium borohydride Solvents: Isopropanol
Reference
Synthesis of sibutramine hydrochloride
Shen, Jingshan; et al, Zhongguo Yiyao Gongye Zazhi, 2001, 32(8), 337-339

Production Method 5

Reaction Conditions
1.1 Solvents: Toluene
1.2 Reagents: Sodium borohydride Solvents: Isopropanol
Reference
Improvement on synthesis of sibutramine
Shen, Jing; et al, Zhongguo Yaowu Huaxue Zazhi, 2000, 10(2), 129-130

Production Method 6

Reaction Conditions
1.1 Reagents: (+)-Di-p-toluoyl-D-tartaric acid Solvents: Tetrahydrofuran ;  22 °C
1.2 Reagents: Borane ;  1.5 h, -60 - -30 °C
1.3 Reagents: Potassium hydroxide Solvents: Water
Reference
Novel diacid accelerated borane reducing agent for imines
Lu, Zhi-Hui; et al, Tetrahedron Letters, 2002, 43(47), 8617-8620

Production Method 7

Reaction Conditions
1.1 Reagents: Potassium hydroxide Solvents: Dimethyl sulfoxide ;  20 °C; 2 h, 20 °C
1.2 Solvents: Water ;  30 °C
2.1 Reagents: Magnesium Catalysts: Iodine Solvents: Tetrahydrofuran ;  rt; 65 °C
2.2 Solvents: Toluene ;  65 °C; 12 h, 90 - 95 °C
2.3 Reagents: Potassium borohydride Solvents: Isopropanol ;  rt; 12 h, 90 - 95 °C
2.4 Solvents: Water ;  30 min, rt
Reference
Syntheses, characterizations and crystal structures of the Schiff bases derived from 1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine
Pen, Zhenshan; et al, Huaxue Tongbao, 2009, 72(9), 820-827

Production Method 8

Reaction Conditions
1.1 Reagents: Formic acid ;  30 min, 160 °C; 24 h, 180 °C
2.1 Reagents: Hydrochloric acid Solvents: Diglyme ,  Water ;  18 h, reflux
2.2 Reagents: Sodium hydroxide Solvents: Water ;  basified
Reference
A Study and Identification of Potential By-Products of Sibutramine
Reddy, G. Om; et al, Organic Process Research & Development, 1999, 3(6), 488-492

Didesmethyl Sibutramine Raw materials

Didesmethyl Sibutramine Preparation Products

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