Production Method 1

147700-58-1

84315-24-2

Reaction Conditions

Reference

Dopamine-β-hydroxylase inhibitors

, European Patent Organization, , ,

Production Method 2

923977-12-2

84315-24-2

Reaction Conditions

1.1 Reagents: Water Solvents: Acetonitrile ;  5 min, rt → 120 °C; 0.5 h, 150 psi, 120 °C

Reference

Efficient synthesis of halo indanones via chlorosulfonic acid mediated Friedel-Crafts cyclization of aryl propionic acids and their use in alkylation reactions

Sharma, Anil K.; et al, Tetrahedron, 2007, 63(2), 389-395

Production Method 3

163978-51-6

84315-24-2

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Ethanol ,  Water
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Epoxidation with dioxiranes derived from 2-fluoro-2-substituted-1-tetralones and -1-indanones

Brown, David S.; et al, Tetrahedron, 1995, 51(12), 3587-606

Production Method 4

141-82-2

32085-88-4

84315-24-2

Reaction Conditions

Reference

Dopamine-β-hydroxylase inhibitors

, European Patent Organization, , ,

Production Method 5

163978-50-5

84315-24-2

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethyl acetate
2.1 Reagents: Potassium hydroxide Solvents: Ethanol ,  Water
2.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Epoxidation with dioxiranes derived from 2-fluoro-2-substituted-1-tetralones and -1-indanones

Brown, David S.; et al, Tetrahedron, 1995, 51(12), 3587-606

Production Method 6

64248-63-1

84315-24-2

Reaction Conditions

1.1 -
2.1 Catalysts: Pyridine
3.1 -

Reference

Dopamine β-hydroxylase inhibitors

, European Patent Organization, , ,

Production Method 7

84315-23-1

84315-24-2

Reaction Conditions

Reference

Dopamine β-hydroxylase inhibitors

, European Patent Organization, , ,

Production Method 8

141-82-2

32085-88-4

84315-24-2

Reaction Conditions

1.1 Catalysts: Pyridine
2.1 -

Reference

Dopamine β-hydroxylase inhibitors

, European Patent Organization, , ,

Production Method 9

2033-24-1

32085-88-4

84315-24-2

Reaction Conditions

1.1 Reagents: Triethylammonium formate
2.1 Reagents: Water Solvents: Acetonitrile ;  5 min, rt → 120 °C; 0.5 h, 150 psi, 120 °C

Reference

Efficient synthesis of halo indanones via chlorosulfonic acid mediated Friedel-Crafts cyclization of aryl propionic acids and their use in alkylation reactions

Sharma, Anil K.; et al, Tetrahedron, 2007, 63(2), 389-395

Production Method 10

1099-45-2

32085-88-4

84315-24-2

Reaction Conditions

1.1 Solvents: Dichloromethane
2.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethyl acetate
3.1 Reagents: Potassium hydroxide Solvents: Ethanol ,  Water
3.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Epoxidation with dioxiranes derived from 2-fluoro-2-substituted-1-tetralones and -1-indanones

Brown, David S.; et al, Tetrahedron, 1995, 51(12), 3587-606

3-(3,5-Difluorophenyl)propionic acid Raw materials

• propanedioic acid
• 2,2-dimethyl-1,3-dioxane-4,6-dione
• trans-3,5-Difluorocinnamic Acid
• 3,5-Difluorocinnamic acid
• Ethyl 3-(3,5-difluorophenyl)acrylate
• Benzenepropanoic acid,3,5-difluoro-, ethyl ester
• ethyl 2-(triphenyl-λ?-phosphanylidene)acetate
• 1,3-Dioxane-4,6-dione, 5-[(3,5-difluorophenyl)methyl]-2,2-dimethyl-
• 3,5-Difluorobenzonitrile
• 3,5-Difluorobenzaldehyde

3-(3,5-Difluorophenyl)propionic acid Preparation Products

• 3-(3,5-Difluorophenyl)propionic acid (84315-24-2)

• 1. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
• 2. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
  Eunhak Lim,Jiyoung Heo,Seong Keun Kim Nanoscale, 2019,11, 11369-11378
• 3. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 4. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
• 5. An analysis of the WTC fires using CIB correlations and simple modeling
  JGQuintiere

• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Phenylpropanoic acids Phenylpropanoic acids
• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Phenylpropanoic acids

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• 161712-75-0(3-(3,4-Difluorophenyl)propanoic acid)
• 162549-35-1(3-(3,5-Difluorophenyl)pentanedioic acid)
• 886499-50-9(3-(3,4,5-Trifluorophenyl)propanoic acid)
• 24484-22-8(5-(4-Fluorophenyl)valeric Acid)
• 458-45-7(3-(3-Fluorophenyl)propionic acid)
• 166251-34-9(3-(4-Fluoro-2-methylphenyl)propanoic acid)
• 893641-14-0(3'-Fluoro-biphenyl-4-propanoic acid)
• 89326-72-7(6-(4-fluorophenyl)hexanoic Acid)