Cas no 163978-50-5 (Ethyl 3-(3,5-difluorophenyl)acrylate)

Ethyl 3-(3,5-difluorophenyl)acrylate is a fluorinated acrylate ester with applications in organic synthesis and pharmaceutical intermediates. Its key advantages include the presence of difluorophenyl and acrylate functional groups, which enhance reactivity in cross-coupling and polymerization reactions. The electron-withdrawing fluorine substituents improve stability and influence the electronic properties of derived compounds. This compound is particularly useful in the preparation of bioactive molecules and advanced materials due to its structural versatility. It is typically handled under controlled conditions to maintain purity and reactivity. The ester group also facilitates further derivatization, making it a valuable building block in medicinal and materials chemistry research.
Ethyl 3-(3,5-difluorophenyl)acrylate structure
163978-50-5 structure
Product Name:Ethyl 3-(3,5-difluorophenyl)acrylate
CAS No:163978-50-5
MF:C11H10F2O2
MW:212.192710399628
CID:110395
PubChem ID:11160162
Update Time:2025-10-16

Ethyl 3-(3,5-difluorophenyl)acrylate Chemical and Physical Properties

Names and Identifiers

    • Ethyl 3-(3,5-difluorophenyl)acrylate
    • 2-Propenoic acid,3-(3,5-difluorophenyl)-, ethyl ester
    • ethyl (E)-3-(3,5-difluorophenyl)prop-2-enoate
    • I01-8554
    • ETHYL 3?5?DIFLUOROCINNAMATE
    • 163978-50-5
    • MFCD03095009
    • EN300-1453851
    • Ethyl 3 5difluorocinnamate
    • ETHYL (2E)-3-(3,5-DIFLUOROPHENYL)PROP-2-ENOATE
    • starbld0014227
    • 861631-72-3
    • AKOS015891004
    • ethyl (E)-3-(35-difluorophenyl)acrylate
    • Ethyl (E)-3-(3,5-difluorophenyl)acrylate
    • 2-Propenoic acid, 3-(3,5-difluorophenyl)-, ethyl ester
    • ETHYL 3-(3,5-DIFLUOROPHENYL)PROP-2-ENOATE
    • DTXSID90457246
    • (E)-3-(3,5-Difluoro-phenyl)-acrylic acid ethyl ester
    • SCHEMBL534282
    • CS-0347721
    • Inchi： 1S/C11H10F2O2/c1-2-15-11(14)4-3-8-5-9(12)7-10(13)6-8/h3-7H,2H2,1H3/b4-3+
    • InChI Key： LMSRIRQMDGZPNZ-ONEGZZNKSA-N
    • SMILES： FC1C=C(C=C(/C=C/C(=O)OCC)C=1)F

Computed Properties

  • Exact Mass: 212.06500
  • Monoisotopic Mass: 212.06488588g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 15
  • Rotatable Bond Count: 4
  • Complexity: 231
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 1
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.8
  • Topological Polar Surface Area: 26.3?2

Experimental Properties

  • Density: 1.21
  • Boiling Point: 262.4°Cat760mmHg
  • Flash Point: 109.2°C
  • Refractive Index: 1.518
  • PSA: 26.30000
  • LogP: 2.54110

Ethyl 3-(3,5-difluorophenyl)acrylate Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
Alichem
A019109131-1g
Ethyl 3-(3,5-difluorophenyl)acrylate
 163978-50-5 95%
1g
 400.00 USD 2021-06-17
Crysdot LLC
CD12135775-5g
Ethyl 3-(3,5-difluorophenyl)acrylate
 163978-50-5 95+%
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Ethyl 3-(3,5-difluorophenyl)acrylate Related Literature

Related Categories

Additional information on Ethyl 3-(3,5-difluorophenyl)acrylate

Comprehensive Overview of Ethyl 3-(3,5-difluorophenyl)acrylate (CAS No. 163978-50-5)

Ethyl 3-(3,5-difluorophenyl)acrylate (CAS No. 163978-50-5) is a fluorinated organic compound widely utilized in pharmaceutical intermediates, agrochemical synthesis, and advanced material research. Its unique 3,5-difluorophenyl moiety and acrylate ester functionality make it a versatile building block for designing bioactive molecules. With the growing demand for fluorinated compounds in drug discovery—driven by their enhanced metabolic stability and membrane permeability—this compound has garnered significant attention from researchers and manufacturers alike.

The structural features of Ethyl 3-(3,5-difluorophenyl)acrylate include a conjugated double bond and an ethyl ester group, which facilitate reactions like Michael additions, cross-coupling, and polymerization. Recent studies highlight its role in developing kinase inhibitors and antimicrobial agents, aligning with the pharmaceutical industry's focus on targeted therapies. Searches for "fluorinated acrylates in drug design" or "CAS 163978-50-5 applications" reflect rising interest in its synthetic utility.

From an industrial perspective, this compound aligns with trends in green chemistry and sustainable synthesis. Researchers are exploring solvent-free reactions and catalytic methods to optimize its production, addressing environmental concerns. Keywords like "eco-friendly synthesis of difluorophenyl acrylates" and "Ethyl 3-(3,5-difluorophenyl)acrylate suppliers" frequently appear in procurement-related queries, underscoring its commercial relevance.

Analytical characterization of Ethyl 3-(3,5-difluorophenyl)acrylate typically involves GC-MS, HPLC, and NMR spectroscopy to ensure purity—a critical factor for high-value applications. The compound's stability under inert conditions makes it suitable for long-term storage, though precautions against light and moisture are recommended. Discussions on "analytical methods for fluorinated acrylates" or "CAS 163978-50-5 stability" are common in technical forums.

In material science, this acrylate derivative serves as a monomer for fluorinated polymers with applications in coatings and electronics. Its ability to impart hydrophobicity and chemical resistance resonates with innovations in water-repellent materials and flexible electronics, topics trending in academic and industrial research. Searches for "difluorophenyl acrylate polymers" or "163978-50-5 material properties" highlight this niche.

Regulatory compliance for Ethyl 3-(3,5-difluorophenyl)acrylate adheres to standard safety protocols for handling organic compounds. While not classified as hazardous under major regulatory frameworks, proper ventilation and PPE are advised during laboratory use. This aligns with broader workplace safety trends, as seen in queries like "safe handling of fluorinated acrylates."

Future prospects for CAS No. 163978-50-5 include expanding its role in bioconjugation and prodrug development, leveraging its reactive sites for tailored modifications. As AI-driven drug discovery accelerates, demand for such specialized intermediates is expected to grow, reinforcing its position in the fine chemicals market.

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