Production Method 1

340322-86-3

84284-70-8

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Methanol ,  Tetrahydrofuran ;  12 h, rt

Reference

Total synthesis of Daphnodorin A

Yuan, Hu; Bi, Kaijian; Chang, Wanlin; Yue, Rongcai; Li, Bo; et al, Tetrahedron, 2014, 70(47), 9084-9092

Production Method 2

114943-73-6

84284-70-8

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Ethylbenzene ,  Tetrahydrofuran ,  Heptane ;  -78 °C; 2 h, -78 °C
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

HIF-1α inhibitors: Synthesis and biological evaluation of novel moracin O and P analogs

Xia, Yan; Jin, Yinglan; Kaur, Navneet; Choi, Yongseok; Lee, Kyeong, European Journal of Medicinal Chemistry, 2011, 46(6), 2386-2396

Production Method 3

114943-73-6

84284-70-8

Reaction Conditions

1.1 Reagents: Ethylmagnesium bromide Solvents: Tetrahydrofuran ;  0.5 h, 0 °C - rt

Reference

Synthesis of yashabushidiol and its analogues and their cytotoxic activity against cancer cell lines

Narasimhulu, M.; Srikanth Reddy, T.; Chinni Mahesh, K.; Sai Krishna, A.; Venkateswara Rao, J.; et al, Bioorganic & Medicinal Chemistry Letters, 2009, 19(11), 3125-3127

Production Method 4

114943-73-6

84284-70-8

Reaction Conditions

1.1 Reagents: Cesium carbonate Solvents: Dimethyl sulfoxide ;  12 h, 115 °C

Reference

Cs2CO3-mediated synthesis of terminal alkynes from 1,1-dibromo-1-alkenes

Zhao, Ming; Kuang, Chunxiang; Yang, Qing; Cheng, Xuezhi, Tetrahedron Letters, 2011, 52(9), 992-994

Production Method 5

4397-53-9

27491-70-9

84284-70-8

Reaction Conditions

1.1 Solvents: Methanol ;  10 min, cooled
1.2 Reagents: Potassium carbonate ;  2 h, cooled; overnight, cooled

Reference

Concise synthesis of dimethyl (2-oxopropyl)phosphonate and homologation of aldehydes to alkynes in a tandem process

Maehr, Hubert; Uskokovic, Milan R.; Schaffner, Carl P., Synthetic Communications, 2009, 39(2), 299-310

Production Method 6

61439-59-6

84284-70-8

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Sulfonyl fluoride Solvents: Dimethyl sulfoxide ;  2 h, rt
1.2 Reagents: Cesium fluoride ;  rt → 100 °C; 2 h, 100 °C; 100 °C → rt

Reference

SO2F2-Mediated Oxidative Dehydrogenation and Dehydration of Alcohols to Alkynes

Zha, Gao-Feng ; Fang, Wan-Yin; Li, You-Gui; Leng, Jing; Chen, Xing; et al, Journal of the American Chemical Society, 2018, 140(50), 17666-17673

Production Method 7

114943-73-6

84284-70-8

Reaction Conditions

1.1 Reagents: tert-Butyllithium Solvents: Tetrahydrofuran ,  Hexane

Reference

New Methods for Organic Synthesis on Solid Supports

Mynett, Donna Maria, 1995, , ,

Production Method 8

114943-73-6

84284-70-8

Reaction Conditions

1.1 Reagents: Succinimide ,  Potassium carbonate Solvents: Dimethyl sulfoxide ;  2 h, 90 °C

Reference

Synthesis of alkynes under dry reaction conditions

Rao, Maddali L. N.; Shamim Islam, Sk, Tetrahedron Letters, 2021, 71,

Production Method 9

340322-86-3

84284-70-8

Reaction Conditions

1.1 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran ,  Water

Reference

Discovery of Carboranes as Inducers of 20S Proteasome Activity

Ban, Hyun Seung; Minegishi, Hidemitsu; Shimizu, Kazuki; Maruyama, Minako; Yasui, Yuka; et al, ChemMedChem, 2010, 5(8), 1236-1241

Production Method 10

340322-86-3

84284-70-8

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Methanol ,  Tetrahydrofuran ;  12 h, rt

Reference

Copper-mediated pentafluoroethylation of organoboronates and terminal alkynes with TMSCF3

Pan, Shitao; Xie, Qiqiang; Wang, Xiu; Wang, Qian; Ni, Chuanfa; et al, Chemical Communications (Cambridge, 2022, 58(33), 5156-5159

Production Method 11

152915-78-1

84284-70-8

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Isopropanol ;  3 h, 80 °C

Reference

New series of AB2-type hyperbranched polytriazoles derived from the same polymeric intermediate: Different endcapping spacers with adjustable bulk and convenient syntheses via click chemistry under copper(I) catalysis

Li, Zhong-An; Wu, Wen-Bo; Qiu, Guo-Fu; Yu, Gui; Liu, Yun-Qi; et al, Journal of Polymer Science, 2011, 49(9), 1977-1987

Production Method 12

340322-86-3

84284-70-8

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Methanol ;  0.5 h, rt

Reference

First Synthesis of the [5-5-6-6] Tetracyclic Framework of Spiropreussione B

Chinta, Bhavani Shankar; Baire, Beeraiah, European Journal of Organic Chemistry, 2017, 2017(24), 3457-3460

Production Method 13

340322-86-3

84284-70-8

Reaction Conditions

1.1 Reagents: Potassium fluoride Solvents: Methanol ;  32 h, rt

Reference

Reactivity Switch Enabled by Counterion: Highly Chemoselective Dimerization and Hydration of Terminal Alkynes

Xu, Caixia; Du, Weiyuan; Zeng, Yi; Dai, Bin; Guo, Hao, Organic Letters, 2014, 16(3), 948-951

Production Method 14

114943-73-6

84284-70-8

Reaction Conditions

1.1 Reagents: Butylmagnesium chloride Solvents: Toluene ,  Tetrahydrofuran ;  rt; 1 h, 110 °C
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

Cu-mediated or metal-free alkylation of gem-dibromoalkenes with tertiary, secondary and primary alkyl grignard reagents

Deng, Yupian; Zhang, Xuxue; Liu, Chuan; Cao, Song, Tetrahedron, 2021, 81,

Production Method 15

90965-06-3

123-08-0

84284-70-8

Reaction Conditions

1.1 Reagents: Potassium carbonate ;  rt
1.2 Reagents: Potassium carbonate Solvents: Methanol ;  0 °C; 0 °C → rt; overnight, rt
1.3 Solvents: Diethyl ether ,  Water ;  rt

Reference

Concise Total Syntheses of Aspalathin and Nothofagin

Yepremyan, Akop; Salehani, Baback; Minehan, Thomas G., Organic Letters, 2010, 12(7), 1580-1583

Production Method 16

6793-92-6

84284-70-8

Reaction Conditions

1.1 Reagents: Triethylamine ,  Tetraphenylporphyrin Catalysts: Cuprous iodide ,  Dichlorobis(triphenylphosphine)palladium
1.2 Reagents: Sodium hydroxide Solvents: Toluene

Reference

Synthesis and evaluation of 1-alkyl-4-phenyl-[1,2,3]-triazole derivatives as antimycobacterial agent

Gallardo, Hugo; Conte, Gilmar; Bryk, Fernando; Lourenco, Maria Cristina S.; Costa, Marilia S.; et al, Journal of the Brazilian Chemical Society, 2007, 18(6), 1285-1291

Production Method 17

340322-86-3

84284-70-8

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Methanol ;  6 h, rt

Reference

Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase

Khabnadideh, Soghra; Pez, Didier; Musso, Alexander; Brun, Reto; Perez, Luis M. Ruiz; et al, Bioorganic & Medicinal Chemistry, 2005, 13(7), 2637-2649

Production Method 18

19578-68-8

1066-54-2

84284-70-8

Reaction Conditions

1.1 Catalysts: Cuprous iodide ,  Dichlorobis(triphenylphosphine)palladium Solvents: 1,4-Dioxane ;  1 h, rt
1.2 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  15 min, rt

Reference

Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative and Tumor Vascular Disrupting Properties

Flynn, Bernard L.; Gill, Gurmit S.; Grobelny, Damian W.; Chaplin, Jason H.; Paul, Dharam; et al, Journal of Medicinal Chemistry, 2011, 54(17), 6014-6027

Production Method 19

766-98-3

100-51-6

84284-70-8

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Dimethyl sulfoxide ;  18 h, 100 °C
1.2 Reagents: Hydrochloric acid Solvents: Dichloromethane ,  Water

Reference

An Alternative Role for Acetylenes: Activation of Fluorobenzenes toward Nucleophilic Aromatic Substitution

Bizier, Nicholas P.; Wackerly, Jay Wm.; Braunstein, Eric D.; Zhang, Mengfei; Nodder, Stephen T.; et al, Journal of Organic Chemistry, 2013, 78(12), 5987-5998

4'-Benzyloxyphenyl Acetylene Raw materials

• 1-Ethynyl-4-fluorobenzene
• 1-Benzyloxy-4-bromobenzene
• ((4-(Benzyloxy)phenyl)ethynyl)trimethylsilane
• 4-(benzyloxy)benzaldehyde
• 4-Benzyloxyiodobenzene
• Dimethyl Diazomethylphosphonate
• Benzyl alcohol
• 4-(4-(Benzyloxy)phenyl)-2-methylbut-3-yn-2-ol
• Dimethyl (1-diazo-2-oxopropyl)phosphonate
• ethynyltrimethylsilane
• 4-Hydroxybenzaldehyde
• 1-(2,2-dibromoethenyl)-4-phenylmethoxybenzene
• 2-(4-Benzyloxyphenyl)ethanol

4'-Benzyloxyphenyl Acetylene Preparation Products

• 4'-Benzyloxyphenyl Acetylene (84284-70-8)

• 1. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
• 2. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130
• 3. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 4. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 5. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555

• Solvents and Organic Chemicals Organic Compounds Acids/Esters
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

• 621-91-0(1,4-Dibenzyloxybenzene)
• 19962-28-8(Benzene,1-methoxy-4-(phenoxymethyl)-)
• 836-43-1(p-Benzyloxybenzyl Alcohol)
• 946-80-5(Benzyl phenyl ether)
• 10403-79-9(Benzene,1,4-bis(phenoxymethyl)-)
• 6630-18-8(4-Benzyloxyanisole)
• 77151-89-4(Phenol, 4-[(4-methoxyphenyl)methoxy]-)
• 201058-08-4(4-Benzyloxybenzyl Alcohol Polystyrene)
• 128133-59-5(1-(benzyloxy)-3-ethynylbenzene)
• 19962-27-7(Benzene, 1-methyl-4-(phenoxymethyl)-)