Production Method 1

1761-61-1

685-87-0

84102-69-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Catalysts: Tetrabutylammonium bromide Solvents: Toluene ;  rt; rt → reflux; 20 h, reflux
1.2 Reagents: Water ;  15 min, rt

Reference

Synthesis of vilazodone hydrochloride

Wang, Qifa; Cheng, Qingfang; Chen, Na; Zheng, Guochuang; Shuai, Mei, Zhongguo Yiyao Gongye Zazhi, 2013, 44(1), 3-5

Production Method 2

1761-61-1

685-87-0

84102-69-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ;  10 h, reflux
1.2 Reagents: Hydrochloric acid Solvents: Water ;  acidified, cooled

Reference

Synthesis, characterization and antimicrobial screening of 5-bromo-benzofuranyl aryl triazoles

Kumari, H. M. Naveena; Mathada, Manjunatha Harihara; Hugar, Shivakumar; Basavaraja, K. M., Journal of Applicable Chemistry (Lumami, 2019, 8(4), 1704-1710

Production Method 3

51336-47-1

84102-69-2

Reaction Conditions

1.1 Catalysts: 2,8,9-Trimethyl-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3]undecane Solvents: Ethanol

Reference

P(MeNCH2CH2)3N: an efficient catalyst for the synthesis of substituted ethyl benzofuran-2-carboxylates

D'Sa, Bosco A.; Kisanga, Philip; Verkade, John G., Synlett, 2001, (5), 670-672

Production Method 4

51336-47-1

84102-69-2

Reaction Conditions

1.1 Reagents: Sodium ethoxide Solvents: Ethanol ;  70 °C

Reference

Synthesis and SAR of highly selective MMP-13 inhibitors

Li, Jianchang; Rush, Thomas S.; Li, Wei; DeVincentis, Dianne; Du, Xuemei; et al, Bioorganic & Medicinal Chemistry Letters, 2005, 15(22), 4961-4966

Production Method 5

1761-61-1

685-87-0

84102-69-2

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Tetrabutylammonium bromide Solvents: Toluene ;  rt; 20 h, reflux
1.2 Solvents: Water ;  15 min, rt

Reference

Improved method for synthesis of vilazodone hydrochloride

Cheng, Qing-fang; Wang, Qi-fa; Qiu, Feng; Tang, Jian-ping; Liao, Yun-peng, Zhongguo Xinyao Zazhi, 2013, 22(2), 226-229

Production Method 6

13939-06-5

1191415-07-2

84102-69-2

Reaction Conditions

1.1 Reagents: Triethylamine Catalysts: 2,2′-Bipyridine ,  Copper bromide (CuBr2) ;  8 h, 90 °C

Reference

Tandem Synthesis of 2-Carboxybenzofurans via Sequential Cu-Catalyzed C-O Coupling and Mo(CO)6-Mediated Carbonylation Reactions

Mo, Qinliang; Sun, Nan ; Jin, Liqun ; Hu, Baoxiang; Shen, Zhenlu ; et al, Journal of Organic Chemistry, 2020, 85(17), 11490-11500

Production Method 7

1761-61-1

105-39-5

84102-69-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  4 h, 92 - 94 °C

Reference

Synthesis of new benzofuran-2-carboxylic acid derivatives

Kowalewska, M.; Kwiecien, H.; Smist, M.; Wrzesniewska, A., Journal of Chemistry, 2013, 183717,

Production Method 8

1761-61-1

105-36-2

84102-69-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  1.5 h, reflux

Reference

Aminostyrylbenzofuran derivatives as potent inhibitors for Aβ fibril formation

Byun, Ji Hun; Kim, HyeYun; Kim, YoungSoo; Mook-Jung, Inhee; Kim, Dong Jin; et al, Bioorganic & Medicinal Chemistry Letters, 2008, 18(20), 5591-5593

Ethyl 5-bromobenzofuran-2-carboxylate Raw materials

• 5-Bromo-2-hydroxybenzaldehyde
• ethyl 2-chloroacetate
• Hexacarbonylmolybdenum
• Ethyl (4-bromo-2-formylphenoxy)acetate
• Ethyl bromoacetate
• 1,3-diethyl 2-bromopropanedioate
• Phenol, 4-bromo-2-(2,2-dibromoethenyl)-

Ethyl 5-bromobenzofuran-2-carboxylate Preparation Products

• Ethyl 5-bromobenzofuran-2-carboxylate (84102-69-2)

• 1. Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides?
  Chen-Yu Chien,Sheng-Sheng Yu Chem. Commun., 2020,56, 11949-11952
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• 5. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
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• 1247406-14-9(methyl 7-bromo-1-benzofuran-2-carboxylate)
• 32730-03-3(Ethyl Naphtho2,1-bfuran-2-carboxylate)
• 1033201-65-8(Ethyl 7-bromobenzofuran-2-carboxylate)
• 3199-61-9(Ethyl Coumarilate)
• 74222-20-1(Naphtho[1,2-b]furan-2-carboxylic acid, ethyl ester)
• 907945-62-4(Ethyl 6-bromo-1-benzofuran-2-carboxylate)
• 10242-11-2(5-Bromo-1-benzofuran-2-carboxylic acid)
• 425675-94-1(Methyl 6-bromobenzofuran-2-carboxylate)
• 26028-36-4(5-Bromobenzofuran-2-carboxylic Acid Methyl Ester)
• 177735-22-7(Ethyl 4-bromo-1-benzofuran-2-carboxylate)