Cas no 83265-53-6 (2-Amino-5-(Trifluoromethyl)benzoic acid)

2-Amino-5-(Trifluoromethyl)benzoic acid structure
83265-53-6 structure
Product Name:2-Amino-5-(Trifluoromethyl)benzoic acid
CAS No:83265-53-6
MF:C8H6F3NO2
MW:205.133952617645
MDL:MFCD01569537
CID:721175
PubChem ID:10465535
Update Time:2024-10-27

2-Amino-5-(Trifluoromethyl)benzoic acid Chemical and Physical Properties

Names and Identifiers

    • 2-Amino-5-(Trifluoromethyl)benzoic acid
    • (4R)-N-(tert- Butyldimethylsilyl)azetidin-2-one-4-carboxylic acid
    • 2-Amino-5-Trifluoromethyl-Benzoic Acid
    • Benzoicacid, 2-amino-5-(trifluoromethyl)-
    • 2-Amino-5-(trifluoromethyl)benzoic acid (ACI)
    • 5-(Trifluoromethyl)anthranilic acid
    • MDL： MFCD01569537
    • Inchi： 1S/C8H6F3NO2/c9-8(10,11)4-1-2-6(12)5(3-4)7(13)14/h1-3H,12H2,(H,13,14)
    • InChI Key： GLCQUPLYYXSPQB-UHFFFAOYSA-N
    • SMILES： O=C(C1C(N)=CC=C(C(F)(F)F)C=1)O

Computed Properties

  • Exact Mass: 205.03500
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 14
  • Rotatable Bond Count: 2

Experimental Properties

  • Melting Point: 190-194°C
  • Boiling Point: 301.6℃ at 760 mmHg
  • Flash Point: >110°(230°F)
  • PSA: 63.32000
  • LogP: 2.56700

2-Amino-5-(Trifluoromethyl)benzoic acid Security Information

2-Amino-5-(Trifluoromethyl)benzoic acid Customs Data

  • HS CODE：2922499990
  • Customs Data：

    China Customs Code:

    2922499990

    Overview:

    2922499990 Other amino acids and their esters and their salts(Except those containing more than one oxygen-containing group). VAT:17.0% Tax refund rate:9.0% Regulatory conditions:AB(Customs clearance form for Inbound Goods,Customs clearance form for outbound goods) MFN tariff:6.5% general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, The color of ethanolamine and its salt should be reported, The package of ethanolamine and its salt shall be declared

    Regulatory conditions:

    A.Customs clearance form for Inbound Goods
    B.Customs clearance form for outbound goods

    Inspection and quarantine category:

    P.Imported animals and plants\Quarantine of animal and plant products
    Q.Outbound animals and plants\Quarantine of animal and plant products
    R.Sanitary supervision and inspection of imported food
    S.Sanitary supervision and inspection of exported food
    M.Import commodity inspection
    N.Export commodity inspection

    Summary:

    HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

2-Amino-5-(Trifluoromethyl)benzoic acid Pricemore >>

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2-Amino-5-(Trifluoromethyl)benzoic acid Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Water ;  overnight, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  10 min, rt
Reference
Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease
Yao, Hong; et al, Journal of Medicinal Chemistry, 2021, 64(11), 7483-7506

Production Method 2

Reaction Conditions
1.1 Reagents: tert-Butyllithium ;  -78 °C
1.2 -78 °C → rt
1.3 Reagents: Hydrochloric acid Solvents: Tetrahydrofuran ,  Water
Reference
Bacterial translation inhibitors, 1-acylindazol-3-ols as anthranilic acid mimics
Stiff, Cory; et al, Bioorganic & Medicinal Chemistry Letters, 2008, 18(23), 6293-6297

2-Amino-5-(Trifluoromethyl)benzoic acid Raw materials

2-Amino-5-(Trifluoromethyl)benzoic acid Preparation Products

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