• 1. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 2. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 3. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 4. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 5. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Aminobenzoic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Aminobenzoic acids and derivatives

Recent Advances in the Application of 3-Amino-4-(trifluoromethyl)benzoic acid (CAS: 125483-00-3) in Chemical Biology and Pharmaceutical Research

3-Amino-4-(trifluoromethyl)benzoic acid (CAS: 125483-00-3) is a fluorinated aromatic compound that has garnered significant attention in recent years due to its versatile applications in medicinal chemistry and drug discovery. The trifluoromethyl group (-CF3) and amino (-NH2) functional groups confer unique physicochemical properties, making this compound a valuable building block for the synthesis of bioactive molecules. This research briefing highlights the latest advancements in the utilization of 3-Amino-4-(trifluoromethyl)benzoic acid, focusing on its role in the development of novel therapeutics and chemical probes.

Recent studies have demonstrated the potential of 3-Amino-4-(trifluoromethyl)benzoic acid as a key intermediate in the synthesis of small-molecule inhibitors targeting various disease-associated proteins. For instance, a 2023 study published in the Journal of Medicinal Chemistry reported the use of this compound in the development of potent inhibitors for protein kinases involved in cancer progression. The researchers employed structure-activity relationship (SAR) studies to optimize the compound's binding affinity and selectivity, resulting in lead candidates with promising in vitro and in vivo efficacy.

In addition to its role in drug discovery, 3-Amino-4-(trifluoromethyl)benzoic acid has been explored as a versatile scaffold for the design of chemical probes in chemical biology. A recent publication in ACS Chemical Biology detailed the synthesis of fluorescent derivatives of this compound, which were used to visualize and track specific cellular processes. The trifluoromethyl group was found to enhance the probes' stability and membrane permeability, making them particularly useful for live-cell imaging applications.

The compound's unique electronic properties, attributed to the electron-withdrawing nature of the -CF3 group, have also been leveraged in materials science. A 2022 study in Advanced Materials demonstrated the incorporation of 3-Amino-4-(trifluoromethyl)benzoic acid into polymeric materials, resulting in enhanced thermal stability and optical properties. These findings open new avenues for the application of this compound in the development of advanced materials for biomedical devices and sensors.

Despite its promising applications, challenges remain in the large-scale synthesis and purification of 3-Amino-4-(trifluoromethyl)benzoic acid. Recent advancements in synthetic methodologies, including flow chemistry and catalytic fluorination, have addressed some of these issues, as reported in a 2023 Organic Process Research & Development article. These innovations have improved the yield and scalability of the compound, facilitating its broader adoption in industrial and academic research settings.

In conclusion, 3-Amino-4-(trifluoromethyl)benzoic acid (CAS: 125483-00-3) continues to be a compound of significant interest in chemical biology and pharmaceutical research. Its unique structural features and versatile applications make it a valuable tool for drug discovery, chemical probe development, and materials science. Ongoing research efforts are expected to further expand its utility and address current limitations in synthesis and application.

• 851045-51-7(Benzoic acid, 2-amino-3-methyl-4-(trifluoromethyl)-)
• 328-68-7(3-Amino-5-(trifluoromethyl)benzoic acid)
• 400-76-0(4-amino-3-(trifluoromethyl)benzoic acid)
• 83265-53-6(2-Amino-5-(Trifluoromethyl)benzoic acid)
• 126541-82-0(Methyl 3-amino-4-(trifluoromethyl)benzoate)
• 313-12-2(2-Amino-3-(trifluoromethyl)benzoic acid)
• 4857-33-4(3-Amino-4-(trifluoromethyl)benzoic acid)
• 197450-26-3(4-(2-Amino-3-(trifluoromethyl)phenyl)benzoic acid)
• 845797-42-4(2-Amino-5-(trifluoromethyl)benzoic acid hydrochloride)
• 402-13-1(2-Amino-4-(trifluoromethyl)benzoic acid)