Production Method 1

621-23-8

1535-67-7

830-79-5

Reaction Conditions

1.1 Catalysts: Tin tetrachloride Solvents: Dichloromethane ;  2 h, rt
1.2 Reagents: 1-Hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide Solvents: Dimethyl sulfoxide ,  Water ;  2 h, rt
1.3 Reagents: Sodium thiosulfate Solvents: Water ;  rt
1.4 Reagents: Sodium bicarbonate Solvents: Water ;  basified, rt

Reference

Electrophilic Aromatic Formylation with Difluoro(phenylsulfanyl) methane

Betterley, Nolan M.; et al, Synthesis, 2018, 50(10), 2033-2040

Production Method 2

621-23-8

1535-67-7

830-79-5

Reaction Conditions

1.1 Catalysts: Bismuth triflate Solvents: 1,1,1,3,3,3-Hexafluoro-2-propanol ;  5 min, rt
1.2 Solvents: 1,1,1,3,3,3-Hexafluoro-2-propanol ;  12 h, rt
1.3 Reagents: 2-Iodoxybenzoic acid Solvents: Dimethyl sulfoxide ,  Water ;  1 h, rt
1.4 Reagents: Sodium sulfite Solvents: Water ;  rt
1.5 Reagents: Sodium bicarbonate Solvents: Water ;  basified, rt

Reference

Bi(OTf)3 Enabled C-F Bond Cleavage in HFIP: Electrophilic Aromatic Formylation with Difluoro(phenylsulfanyl)methane

Betterley, Nolan M.; et al, Asian Journal of Organic Chemistry, 2018, 7(8), 1642-1647

Production Method 3

61040-78-6

830-79-5

Reaction Conditions

1.1 Reagents: Oxygen ,  ABTS Catalysts: Laccase Solvents: Water

Reference

Comparing the catalytic efficiency of some mediators of laccase

Fabbrini, Maura; et al, Journal of Molecular Catalysis B: Enzymatic, 2002, 16(5-6), 231-240

Production Method 4

61040-78-6

830-79-5

Reaction Conditions

1.1 Reagents: Potassium carbonate Catalysts: Palladium Solvents: Toluene ;  90 °C

Reference

Highly dispersed palladium nanoparticles supported on an imidazolium-based ionic liquid polymer: an efficient catalyst for oxidation of alcohols

Karimi, Z.; et al, Russian Chemical Bulletin, 2022, 71(6), 1194-1203

Production Method 5

621-23-8

4885-02-3

830-79-5

Reaction Conditions

1.1 Reagents: Titanium tetrachloride Solvents: Dichloromethane ;  0 °C; 1 h
1.2 45 min
1.3 Reagents: Ammonium chloride Solvents: Water ;  2 h

Reference

Formylation of electron-rich aromatic rings mediated by dichloromethyl methyl ether and TiCl4: scope and limitations

Ramos-Tomillero, Ivan; et al, Molecules, 2015, 20(4), 5409-5422

Production Method 6

621-23-8

830-79-5

Reaction Conditions

1.1 Reagents: Boron trifluoride etherate ,  Triethyl orthoformate Solvents: Dichloromethane
1.2 Reagents: Water

Reference

First reactions of dialkoxycarbenium tetrafluoroborates with pyrroles, 5H-dibenz[b,f]azepines, and electron-rich arenes

Pindur, U.; et al, Journal of Heterocyclic Chemistry, 1989, 26(6), 1563-8

Production Method 7

62778-01-2

830-79-5

Reaction Conditions

1.1 Reagents: Triethylamine Catalysts: Triphenylphosphine Solvents: DMSO-d6 ;  rt → 120 °C; 12 h, 120 °C

Reference

Triphenylphosphine/Triethylamine-Mediated Decarboxylation of α-Oxocarboxylic Acids and Application in a One-Pot Synthesis of Deuterated Aldehydes.

Niu, Guang-Hao; et al, Asian Journal of Organic Chemistry, 2016, 5(1), 57-61

Production Method 8

830-79-5

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ;  6 h, rt → reflux
2.1 Reagents: Phosphorus oxychloride ;  15 - 20 min, 0 °C; 1 h, rt
2.2 Reagents: Potassium hydroxide Solvents: Water ;  basified, 0 °C

Reference

Synthesis of structurally diverse biflavonoids

Sum, Tze Jing; et al, Tetrahedron, 2018, 74(38), 5089-5101

Production Method 9

830-79-5

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ;  8 h, 60 - 70 °C
2.1 Reagents: Phosphorus oxychloride ;  0 °C; 1 h, rt
2.2 Reagents: Potassium hydroxide Solvents: Water ;  basified, cooled

Reference

Synthesis of new C-dimethylated chalcones as potent antitubercular agents

Anandam, Rambabu; et al, Medicinal Chemistry Research, 2018, 27(6), 1690-1704

Production Method 10

63665-97-4

830-79-5

Reaction Conditions

1.1 -
2.1 Reagents: Phosphorus oxychloride

Reference

The Vilsmeier reaction of fully conjugated carbocycles and heterocycles

Jones, Gurnos; et al, Organic Reactions (Hoboken, 1997, 49,

Production Method 11

621-23-8

830-79-5

2510-49-8

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  0 °C; 2 h, 0 °C
1.2 0 °C; 2 h, rt
1.3 Solvents: Methanol ;  30 min, rt
1.4 Reagents: Potassium carbonate ,  Iodine ;  0 °C; 41 h, rt
1.5 Reagents: Sodium sulfite Solvents: Water ;  rt

Reference

Facile preparation of aromatic esters from aromatic bromides with ethyl formate or DMF and molecular iodine via aryllithium

Ushijima, Sousuke; et al, Tetrahedron, 2012, 68(24), 4701-4709

Production Method 12

621-23-8

830-79-5

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride Solvents: Dimethylformamide ;  45 min, 0 °C; 1 h, 0 °C
1.2 Reagents: Potassium carbonate Solvents: Water ;  pH 9 - 10

Reference

Enantioselective Ring Opening of meso-Epoxides with Silicon Tetrachloride Catalyzed by Pyridine N-Oxides Fused with the Bicyclo[3.3.1]nonane Framework

Neniskis, Algirdas; et al, European Journal of Organic Chemistry, 2015, 2015(28), 6359-6369

Production Method 13

949593-49-1

830-79-5

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  0 °C; 1 h, rt
1.2 Reagents: Potassium hydroxide Solvents: Water ;  basified, cooled

Reference

Synthesis of new C-dimethylated chalcones as potent antitubercular agents

Anandam, Rambabu; et al, Medicinal Chemistry Research, 2018, 27(6), 1690-1704

Production Method 14

621-23-8

93-61-8

830-79-5

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  5 - 10 min, 40 - 50 °C
1.2 15 min, 70 °C
1.3 Solvents: Water ;  1 h, cooled

Reference

Sulfur-Substituted α-Alkyl Phenethylamines as Selective and Reversible MAO-A Inhibitors: Biological Activities, CoMFA Analysis, and Active Site Modeling

Gallardo-Godoy, Alejandra; et al, Journal of Medicinal Chemistry, 2005, 48(7), 2407-2419

Production Method 15

621-23-8

93-61-8

830-79-5

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride Solvents: Diethyl ether

Reference

Alkyl-oxygen fission in carboxylic esters. XI. Reactions of secondary alcohols containing the 2,4,6-trimethoxyphenyl radical

Kenyon, J.; et al, Journal of the Chemical Society, 1952, 4964, 4964-9

Production Method 16

621-23-8

830-79-5

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Benzene

Reference

Mescaline analogs. I. 2,4,6-Trialkoxyphenethylmines

Benington, F.; et al, Journal of Organic Chemistry, 1954, 19, 11-16

Production Method 17

40243-91-2

830-79-5

Reaction Conditions

1.1 Reagents: Hydrogen peroxide Catalysts: Vanadium oxide (V2O5) (supported on TiO2) Solvents: Acetonitrile ;  4 h, 30 °C

Reference

V2O5@TiO2 Catalyzed Green and Selective Oxidation of Alcohols, Alkylbenzenes and Styrenes to Carbonyls

Upadhyay, Rahul ; et al, ChemCatChem, 2021, 13(16), 3594-3600

Production Method 18

61040-78-6

830-79-5

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Oxygen Catalysts: Palladium Solvents: Toluene ;  11 h, 90 °C

Reference

Palladium pincer complex incorporation onto the Fe3O4-entrapped crosslinked multilayered polymer as a high loaded nanocatalyst for oxidation

Zohreh, Nasrin; et al, Journal of Molecular Liquids, 2018, 266, 393-404

Production Method 19

830-79-5

Reaction Conditions

Reference

Photosensitized electron-transfer reaction of 3-aryl-2-methyloxaziridine: direct deoxygenation from the isomeric arylnitrone

Iwano, Yasunori; et al, Bulletin of the Chemical Society of Japan, 1994, 67(8), 2348-50

Production Method 20

830-79-5

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone
2.1 Reagents: Phosphorus oxychloride Solvents: Dimethylformamide

Reference

New convenient synthesis of 8-C-methylated homoisoflavones and analysis of their structure by NMR and tandem mass spectrometry

Yadav, Santosh Kumar, International Journal of Organic Chemistry, 2021, 11(1), 46-54

Production Method 21

224156-28-9

830-79-5

Reaction Conditions

1.1 -
2.1 Reagents: Phosphorus oxychloride

Reference

The Vilsmeier reaction of fully conjugated carbocycles and heterocycles

Jones, Gurnos; et al, Organic Reactions (Hoboken, 1997, 49,

Production Method 22

570-02-5

830-79-5

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  4 h, reflux
1.2 2 h, reflux
2.1 Reagents: Phosphorus oxychloride ;  cooled; 3 h, rt
2.2 Reagents: Sodium hydroxide Solvents: Water ;  overnight, neutralized

Reference

Synthesis of stable free radicals as potential organic metals. Synthesis of oxygenated indacene derivatives. Reactions of aromatic poly(N,N-dimethylamides) with electrophiles

Armstrong, Mark Wayne, 1983, , ,

Production Method 23

44205-36-9

830-79-5

Reaction Conditions

1.1 -
2.1 -
3.1 Reagents: Phosphorus oxychloride

Reference

The Vilsmeier reaction of fully conjugated carbocycles and heterocycles

Jones, Gurnos; et al, Organic Reactions (Hoboken, 1997, 49,

Production Method 24

621-23-8

4885-02-3

830-79-5

591228-81-8

Reaction Conditions

1.1 Catalysts: Silver triflate Solvents: Dichloromethane ;  -78 °C; 15 min, 0 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  30 min, rt

Reference

A Direct and Mild Formylation Method for Substituted Benzenes Utilizing Dichloromethyl Methyl Ether-Silver Trifluoromethanesulfonate

Ohsawa, Kosuke; et al, Journal of Organic Chemistry, 2013, 78(7), 3438-3444

Production Method 25

32316-92-0

830-79-5

13250-06-1

Reaction Conditions

1.1 Reagents: Tripotassium phosphate Catalysts: Iridium(1+), [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-κN1,κN1′]bis[3,5-diflu… Solvents: Dichloromethane ;  12 h, 40 °C

Reference

Visible-Light-Mediated Late-Stage Sulfonylation of Boronic Acids via N-S Bond Activation of Sulfonamides

Zhen, Jingsong; et al, ACS Catalysis, 2022, 12(3), 1986-1991

2,4,6-Trimethoxybenzaldehyde Raw materials

• 2-oxo-2-(2,4,6-trimethoxyphenyl)acetic acid
• 1,3,5-Trimethoxybenzene
• N-(Chloromethylidene)-N-methylmethanaminium
• Dichlorophosphoryloxymethylidene(dimethyl)azanium
• N-Methylformanilide
• 2-ethenyl-1,3,5-trimethoxybenzene
• 2,4,6-Trimethoxybenzyl Alcohol
• 2-Naphthylboronic acid
• 1,1-Dichlorodimethyl ether
• 2,4,6-Trimethoxybenzoic acid
• Difluoromethyl Phenyl Sulfide
• 2,4,6-Trimethoxy-1,3,5-benzenetriol
• Phosphorodichloridic acid, chloro(dimethylamino)methyl ester

2,4,6-Trimethoxybenzaldehyde Preparation Products

• 1,3-BENZENEDICARBOXALDEHYDE, 2,4,6-TRIMETHOXY- (591228-81-8)
• 2-iodo-1,3,5-trimethoxybenzene (2510-49-8)
• 2-naphthyl-p-tolyl sulfone (13250-06-1)
• 2,4,6-Trimethoxybenzaldehyde (830-79-5)

• 1. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoyl derivatives
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone

• 708-76-9(4,6-Dimethoxysalicylaldehyde)
• 125666-65-1(2,6-Diformyl-3,5-dimethoxyphenol)
• 118093-05-3(Benzaldehyde,4,6-dihydroxy-2-methoxy-3-methyl-)
• 3392-97-0(2,6-Dimethoxybenzaldehyde)
• 122283-23-2(2-(3-Methoxyphenoxy)benzaldehyde)
• 18278-34-7(4-Hydroxy-2-methoxybenzaldehyde)
• 22080-96-2(4-Hydroxy-2,6-dimethoxybenzaldehyde)
• 700-44-7(2-Hydroxy-6-methoxybenzaldehyde)
• 613-45-6(2,4-Dimethoxybenzaldehyde)
• 39503-23-6(Benzaldehyde,2-hydroxy-6-methoxy-4-methyl-)