Production Method 1

93-61-8

Reaction Conditions

1.1 Reagents: Phenylsilane Catalysts: Zinc ,  1,3,5-Benzenetricarboxaldehyde, 2,4,6-trihydroxy-, polymer with 1,4-benzenediami… Solvents: Dimethylformamide ;  18 h, 1 bar, 30 °C

Reference

Covalent organic framework-supported Zn single atom catalyst for highly efficient N-formylation of amines with CO2 under mild conditions

Cao, Qiang; Zhang, Long-Long; Zhou, Chang; He, Jing-Hui; Marcomini, Antonio; et al, Applied Catalysis, 2021, 294,

Production Method 2

93-61-8

Reaction Conditions

1.1 Reagents: Potassium carbonate Catalysts: 1-Propanaminium, 3-bromo-N-(carboxymethyl)-N,N-dimethyl-, inner salt ,  1,4-Benzenedicarboxaldehyde, 2,5-dihydroxy-, polymer with 5′-(4-aminophenyl)[1,1… Solvents: Dimethylformamide ;  36 h, reflux
1.2 Reagents: Phenylsilane Solvents: Acetonitrile ;  24 h, 5 bar, 35 °C; 35 °C → 0 °C
1.3 Solvents: Ethyl acetate

Reference

Zwitterionic Covalent Organic Frameworks as Catalysts for Hierarchical Reduction of CO2 with Amine and Hydrosilane

Mu, Zhen-Jie; Ding, Xuesong; Chen, Zhi-Yan; Han, Bao-Hang, ACS Applied Materials & Interfaces, 2018, 10(48), 41350-41358

Production Method 3

93-61-8

Reaction Conditions

1.1 Reagents: Phenylsilane Catalysts: Cyclohexyldiphenylphosphine ,  Basic copper carbonate Solvents: Acetonitrile ;  12 h, 1 atm, 60 °C

Reference

Copper catalysis: ligand-controlled selective N-methylation or N-formylation of amines with CO2 and phenylsilane

Li, Xue-Dong; Xia, Shu-Mei; Chen, Kai-Hong; Liu, Xiao-Fang; Li, Hong-Ru; et al, Green Chemistry, 2018, 20(21), 4853-4858

Production Method 4

93-61-8

Reaction Conditions

1.1 Reagents: Phenylsilane Catalysts: Bis(2-pyridinecarboxylato-κN1,κO2)silver Solvents: Toluene ;  12 h, 1 MPa, 25 °C

Reference

Silver-catalyzed Reductive Formylation of Amines with Carbon Dioxide

Uema, Seiya; Sekine, Kenshiro; Aoshima, Ryotaro; Saito, Kodai; Yamada, Tohru, Chemistry Letters, 2023, 52(7), 546-548

Production Method 5

93-61-8

Reaction Conditions

1.1 Catalysts: Copper oxide (CuO) ,  Iron oxide (Fe3O4) ;  25 °C

Reference

Facile N-Formylation of Amines on Magnetic Fe3O4-CuO Nanocomposites

Mishra, Kanchan ; Datta Khanal, Hari ; Rok Lee, Yong, European Journal of Organic Chemistry, 2021, 2021(31), 4477-4484

Production Method 6

93-61-8

Reaction Conditions

1.1 Catalysts: 1,3,5-Benzenetricarboxaldehyde, 2,4,6-trihydroxy-, polymer with 1,4-benzenediami… (doped with zinc) Solvents: Dimethylformamide ;  18 h, 1 atm, 30 °C

Reference

Method for preparing formamide compound with carbon dioxide as carbon source catalyzed by MCOF at normal temperature and pressure

, China, , ,

Production Method 7

93-61-8

Reaction Conditions

1.1 Catalysts: Alanine, N-[bis(dimethylamino)methylene]-, ethyl ester, hydrobromide (1:1) ;  12 h, rt

Reference

Preparation of alkyl-substituted ethyl acetate-based guanidine ionic liquid as catalyst for formylation and methylation of carbon dioxide and N-methylaniline derivatives

, China, , ,

Production Method 8

93-61-8

Reaction Conditions

1.1 Reagents: Phenylsilane Catalysts: Pyrimido[1,2-a]azepinium, 1-dodecyl-2,3,4,6,7,8,9,10-octahydro-, bromide (1:1) ;  6 h, 0.5 MPa, rt

Reference

Design of Lewis base functionalized ionic liquids for the N-formylation of amines with CO2 and hydrosilane: The cation effects

Li, Xiao-Ya; Fu, Hong-Chen; Liu, Xiao-Fang; Yang, Shu-Han; Chen, Kai-Hong ; et al, Catalysis Today, 2020, 356, 563-569

Production Method 9

667-27-6

93-61-8

Reaction Conditions

1.1 Reagents: Sodium carbonate Catalysts: Bis(pinacolato)diborane Solvents: Acetonitrile ;  16 h, 100 °C

Reference

Halodifluoroacetates as formylation reagents for various amines via unprecedented quadruple cleavage

Ma, Xingxing; Deng, Shuilin; Song, Qiuling, Organic Chemistry Frontiers, 2018, 5(24), 3505-3509

Production Method 10

93-61-8

Reaction Conditions

1.1 Reagents: Phenylsilane Catalysts: 2056006-59-6 ;  0.5 MPa, heated; 1.5 h, 0.1 MPa, 40 °C

Reference

Cooperative Catalytic Activation of Si-H Bonds: CO2-Based Synthesis of Formamides from Amines and Hydrosilanes under Mild Conditions

Luo, Rongchang; Lin, Xiaowei; Chen, Yaju; Zhang, Wuying; Zhou, Xiantai; et al, ChemSusChem, 2017, 10(6), 1224-1232

Production Method 11

93-61-8

Reaction Conditions

1.1 Reagents: Ethylbenzene Catalysts: (T-4)-[[2,2′-[1,2-Ethanediylbis[(nitrilo-κN)methylidyne]]bis[phenolato-κO]](2-)]… ,  Aluminum(1+), [[2,2′-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[phenolato-κ… ;  3 h, 5 MPa, 100 °C

Reference

Method for preparing N-formamide compound

, China, , ,

Production Method 12

93-61-8

Reaction Conditions

1.1 Reagents: Acetic acid ,  Hydrogen peroxide Catalysts: 1629122-05-9 Solvents: 1,4-Dioxane ,  Water ;  1 h, rt; 1 h, rt

Reference

[FeIII(TF4DMAP)OTf] catalyzed anti-Markovnikov oxidation of terminal aryl alkenes to aldehydes and transformation of methyl aryl tertiary amines to formamides with H2O2 as a terminal oxidant

Du, Yi-Dan; Tse, Chun-Wai; Xu, Zhen-Jiang; Liu, Yungen; Che, Chi-Ming, Chemical Communications (Cambridge, 2014, 50(84), 12669-12672

Production Method 13

93-61-8

Reaction Conditions

1.1 Catalysts: 1,8-Diazabicyclo[5.4.0]undec-7-ene ,  Divinylbenzene-styrene copolymer (supported on polystyrene) Solvents: Acetonitrile ;  10 min, 30 °C
1.2 Reagents: Trimethoxysilane ;  18 h, 30 °C

Reference

Organocatalytic N-formylation of amines by CO2 in batch and continuous flow

Zanda, Nicola; Primitivo, Ludovica; Chaudhari, Moreshwar; Kleij, Arjan W.; Pericas, Miquel A., Organic Chemistry Frontiers, 2023, 10(2), 375-381

Production Method 14

93-61-8

Reaction Conditions

1.1 Reagents: Phenylsilane Catalysts: 2365082-47-7 ;  24 h, 1 atm, 30 °C

Reference

Unexpected Macrocyclic Multinuclear Zinc and Nickel Complexes that Function as Multitasking Catalysts for CO2 Fixations

Takaishi, Kazuto ; Nath, Bikash Dev; Yamada, Yuya; Kosugi, Hiroyasu; Ema, Tadashi, Angewandte Chemie, 2019, 58(29), 9984-9988

Production Method 15

93-61-8

Reaction Conditions

1.1 Reagents: Phenylsilane Catalysts: Kamacite (Fe0.92-0.96Ni0.04-0.08) ,  Plessite ,  Taenite (Fe0.35-0.73Ni0.27-0.65) Solvents: Dimethylformamide ;  15 h, 10 bar, 25 °C

Reference

Iron-Rich Natural Mineral Gibeon Meteorite Catalyzed N-formylation of Amines using CO2 as the C1 Source

Gopakumar, Aswin; Akcok, Ismail; Lombardo, Loris; Le Formal, Florian; Magrez, Arnaud; et al, ChemistrySelect, 2018, 3(37), 10271-10276

Production Method 16

93-61-8

Reaction Conditions

1.1 Reagents: Triethoxysilane Solvents: Acetonitrile ;  5 min, rt
1.2 Catalysts: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  12 h, 1 bar, 30 °C

Reference

Fluoride-Catalyzed Methylation of Amines by Reductive Functionalization of CO2 with Hydrosilanes

Liu, Xiao-Fang; Ma, Ran; Qiao, Chang; Cao, Han; He, Liang-Nian, Chemistry - A European Journal, 2016, 22(46), 16489-16493

Production Method 17

93-61-8

Reaction Conditions

1.1 Reagents: Phenylsilane Catalysts: 2577138-44-2 (ethers with 4-bromo-N,N,N-triethyl- 1-butanaminium bromide) ;  16 h, 1 MPa, 40 °C

Reference

Sustainable synthesis of multifunctional porous metalloporphyrin polymers for efficient carbon dioxide transformation under mild conditions

Chen, Yaju ; Ren, Qinggang; Zeng, Xiaojing; Tao, Leiming; Zhou, Xiantai ; et al, Chemical Engineering Science, 2021, 232,

Production Method 18

667-27-6

93-61-8

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Water Solvents: Acetonitrile ;  10 h, 90 °C

Reference

Deconstructive Functionalizations of Unstrained Carbon-Nitrogen Cleavage Enabled by Difluorocarbene

Su, Jianke; Ma, Xingxing; Ou, Zongliang; Song, Qiuling, ACS Central Science, 2020, 6(10), 1819-1826

Production Method 19

93-61-8

Reaction Conditions

1.1 Reagents: Dimethylformamide ,  Phenylsilane Catalysts: Zinc phthalocyanine ;  6 h, 0.5 MPa, 25 °C

Reference

Zinc phthalocyanine as an efficient catalyst for halogen-free synthesis of formamides from amines via carbon dioxide hydrosilylation under mild conditions

Luo, Rong-chang; Lin, Xiao-wei; Lu, Jing; Zhou, Xian-tai; Ji, Hong-bing, Chinese Journal of Catalysis, 2017, 38(8), 1382-1389

Production Method 20

93-61-8

Reaction Conditions

1.1 Reagents: Phenylsilane Catalysts: Tetrabutylammonium fluoride ;  5 min, rt; 6 h, 1 atm, rt

Reference

CO2-based N-formylation of Amines Catalyzed by Fluoride and Hydroxide Anions

Hulla, Martin; Bobbink, Felix Daniel; Das, Shoubhik; Dyson, Paul J., ChemCatChem, 2016, 8(21), 3338-3342

N-Methylformanilide Raw materials

• ethyl 2-bromo-2,2-difluoroacetate

N-Methylformanilide Preparation Products

• N-Methylformanilide (93-61-8)

• 1. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 2. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
• 3. An alkynylboronatecycloaddition strategy to functionalised benzyne derivatives?
  James D. Kirkham,Patrick M. Delaney,George J. Ellames,Eleanor C. Row,Joseph P. A. Harrity Chem. Commun., 2010,46, 5154-5156
• 4. Aggregation of biologically important peptides and proteins: inhibition or acceleration depending on protein and metal ion concentrations
  Benjamin Gabriel Poulson,Kacper Szczepski,Joanna Izabela Lachowicz,Lukasz Jaremko,Abdul-Hamid Emwas,Mariusz Jaremko RSC Adv., 2020,10, 215-227
• 5. An analyte-triggered artificial peroxidase system based on dimanganese complex for a versatile enzyme assay?
  Suji Lee,Min Su Han Chem. Commun., 2021,57, 9450-9453

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Anilides
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

• 103-70-8(Formanilide)
• 2739-04-0(N,4'-Dimethylformanilide)
• 25227-79-6(Formamide,N,N'-1,3-phenylenebis- (9CI))
• 18606-63-8( )
• 83968-28-9(Formaldehyde, reaction products with N,N-dimethylbenzenamine and N-methylbenzenamine, oxidized, hydrochlorides)
• 254898-60-7(Formamide,N-(3-aminophenyl)-N-methyl-)
• 84281-86-7(Formaldehyde, reaction products with N,N-dimethylbenzenamine and N-methylbenzenamine, oxidized)
• 262368-26-3(Formamide,N-(4-aminophenyl)-N-methyl-)
• 61289-65-4(Formamide, N-[8-(formylamino)-1-naphthalenyl]-N-methyl-)
• 607-00-1(N,N-Diphenylformamide)