Production Method 1

151-10-0

829-20-9

Reaction Conditions

1.1 4 h, 393 K

Reference

Synthesis of industrially important aromatic and heterocyclic ketones using hierarchical ZSM-5 and Beta zeolites

Kore, Rajkumar; et al, Applied Catalysis, 2015, 493, 129-141

Production Method 2

151-10-0

829-20-9

Reaction Conditions

1.1 Catalysts: Benzenesulfonic acid, 4-methyl-, indium(3+) salt (3:1) Solvents: Nitromethane ;  2 h, reflux

Reference

Catalysis of the acylation of aromatic derivatives by metallic tosylates

Morizur, Vincent; et al, Tetrahedron, 2015, 71(38), 6813-6817

Production Method 3

89-84-9

829-20-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone

Reference

Synthesis of acyclic and cyclic phosphonates based on substituted 2-hydroxybenzylic alcohols

Terekhova, N. V.; et al, Russian Chemical Bulletin, 2020, 69(11), 2147-2152

Production Method 4

829-19-6

829-20-9

Reaction Conditions

1.1 Reagents: Acetone ,  Sodium tert-butoxide Catalysts: Stereoisomer of [1,8-bis[bis(1-methylethyl)phosphino-κP]-9,10[1′,2′]-benzenoanth… Solvents: Acetone ;  56 °C; 6 h, 56 °C

Reference

Cyclometalated phosphine-based Ir(III) pincer complex as a catalyst for Oppenauer-type oxidation of alcohols

Levy, Roy; et al, Catalysis Communications, 2009, 11(4), 298-301

Production Method 5

829-19-6

829-20-9

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Palladium (solid-supported) Solvents: Toluene ;  5 h, 110 °C

Reference

Solid-supported Pd(0): an efficient heterogeneous catalyst for aerobic oxidation of benzyl alcohols into aldehydes and ketones

Bandna; et al, Tetrahedron Letters, 2011, 52(38), 4954-4956

Production Method 6

151-10-0

829-20-9

Reaction Conditions

1.1 Reagents: Water Catalysts: Trifluoromethanesulfonic acid Solvents: Water

Reference

The chemistry of nitrilium salts. Part 1. Acylation of phenols and phenol ethers with nitriles and trifluoromethanesulfonic acid

Booth, Brian L.; et al, Journal of the Chemical Society, 1980, (12), 2894-900

Production Method 7

89-84-9

829-20-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ;  rt; 44 h, reflux

Reference

Peptoid Helix Displaying Flavone and Porphyrin: Synthesis and Intramolecular Energy Transfer

Yang, Woojin; et al, Journal of Organic Chemistry, 2020, 85(3), 1392-1400

Production Method 8

89-84-9

829-20-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  16 h, rt

Reference

Kolbe-Schmitt type reaction under ambient conditions mediated by an organic base

Sadamitsu, Yuta; et al, Chemical Communications (Cambridge, 2019, 55(66), 9837-9840

Production Method 9

18986-10-2

829-20-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile

Reference

Facile transformation of N,N-dimethylhydrazones and tosylhydrazones to ketones with dimethyl sulfate and potassium carbonate

Kamal, Ahmed; et al, Synthetic Communications, 1998, 28(21), 3927-3931

Production Method 10

829-20-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile

Reference

Facile transformation of N,N-dimethylhydrazones and tosylhydrazones to ketones with dimethyl sulfate and potassium carbonate

Kamal, Ahmed; et al, Synthetic Communications, 1998, 28(21), 3927-3931

Production Method 11

917-54-4

91-52-1

829-20-9

Reaction Conditions

1.1 Solvents: Diethyl ether ,  Tetrahydrofuran ;  1 h, -78 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

A novel synthesis of flavones from 2-methoxybenzoic acids

Lee, Jae In; et al, Bulletin of the Korean Chemical Society, 2005, 26(9), 1461-1463

Production Method 12

23997-80-0

829-20-9

Reaction Conditions

1.1 Reagents: N,N-Dibromobenzenesulfonamide Solvents: Carbon tetrachloride ;  30 min, rt

Reference

N,N-dibromobenzenesulfonamide as a reagent for oxidative cleavage of oximes to their parent carbonyl compounds under non-aqueous and aprotic conditions

Tajbakhsh, Mahmood; et al, Journal of Chemical Research, 2004, (2), 141-142

Production Method 13

21963-22-4

151-10-0

37181-39-8

829-20-9

Reaction Conditions

1.1 -
2.1 Catalysts: Sodium bicarbonate

Reference

The chemistry of nitrilium salts. Part 3. The importance of triazinium salts in Houben-Hoesch reactions catalyzed by trifluoromethanesulfonic acid

Amer, Muhannad I.; et al, Journal of the Chemical Society, 1983, (5), 1075-81

Production Method 14

688016-65-1

829-20-9

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Montmorillonite ((Al1.33-1.67Mg0.33-0.67)(Ca0-1Na0-1)0.33Si4(OH)2O10.xH2O) ;  rt; 12 h, rt

Reference

A facile deprotection of N,N-dimethylhydrazones using montmorillonite KSF as catalyst

Hosseinzadeh, Rahmam; et al, Chemistry: An Indian Journal, 2003, 1(1), 53-56

Production Method 15

151-10-0

829-20-9

Reaction Conditions

1.1 Catalysts: 4′-(4-Hydroxyphenyl)-2,2′:6′,2′′-terpyridine (reaction products with poly{[(hydroxyphenyl)methylene]-methylphosphoro…) ,  Scandium triflate ,  Phosphorodichloridothioic hydrazide, 2-[(4-hydroxyphenyl)methylene]-1-methyl-, h… (terpyridinylphenyl-terminated) Solvents: Acetonitrile ;  15 min, rt
1.2 30 min, heated

Reference

Efficient and recyclable rare earth-based catalysts for Friedel-Crafts acylations under microwave heating: dendrimers show the way

Perrier, Arnaud; et al, Green Chemistry, 2013, 15(8), 2075-2080

Production Method 16

151-10-0

829-20-9

Reaction Conditions

1.1 Catalysts: Benzenemethanaminium, N,N,N-triethyl-, μ-chlorodecachlorodiantimonate(1-) Solvents: Nitromethane ;  20 min, reflux

Reference

Friedel-Crafts acylation reactions using catalytic SbCl5-TEBA complex as an efficient catalyst

Huang, An Ping; et al, Chinese Chemical Letters, 2004, 15(12), 1415-1418

Production Method 17

829-20-9

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  10 min, pH 10, reflux

Reference

Reactions of nitrilium salts with indole and pyrrole and their derivatives in the synthesis of imines, ketones and secondary amines

Giles, Robert G.; et al, Tetrahedron, 2015, 71(39), 7367-7385

Production Method 18

89-84-9

829-20-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ;  12 h, 65 °C

Reference

Synthesis of 2',4'-dimethoxychalcone derivatives and evaluation of their antitumor activities against non-small cell lung cancer

Choi, Myeong A.; et al, Yakhak Hoechi, 2016, 60(3), 135-140

Production Method 19

829-19-6

829-20-9

Reaction Conditions

1.1 Reagents: tert-Butyl hydroperoxide Catalysts: Eosin Solvents: Acetonitrile ,  Decane ;  24 h, 25 °C

Reference

Visible light mediated chemo-selective oxidation of benzylic alcohols

Devari, Shekaraiah; et al, Tetrahedron Letters, 2016, 57(30), 3294-3297

Production Method 20

917-54-4

91-52-1

829-20-9

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  0.5 - 2 h, -78 °C
1.2 Reagents: Water ,  Hydrogen ion

Reference

A new route for the synthesis of flavanones from 2-methoxybenzoic acids

Lee, Jae In; et al, Bulletin of the Korean Chemical Society, 2005, 26(12), 2044-2046

Production Method 21

23997-80-0

829-20-9

Reaction Conditions

1.1 Reagents: N,N-Dibromobenzenesulfonamide Solvents: Carbon tetrachloride ;  30 min, 20 - 25 °C

Reference

Deoximation with N-Bromosulfonamides

Tajbaksh, M.; et al, Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii), 2003, 39(7), 1053-1054

Production Method 22

150-78-7

829-20-9

Reaction Conditions

1.1 Reagents: Aluminum chloride Solvents: Dichloromethane ;  4 h, rt

Reference

Synthesis of 2,5-dimethoxyethylbenzene

Chen, Guan-fan; et al, Hecheng Huaxue, 2003, 11(5), 443-444

Production Method 23

151-10-0

38447-66-4

829-20-9

Reaction Conditions

1.1 Catalysts: 9,10-Dimethylanthracene Solvents: Acetonitrile ;  15 - 20 h

Reference

p-Selective (sp2)-C-H functionalization for an acylation/alkylation reaction using organic photoredox catalysis

Pandey, Ganesh; et al, Chemical Communications (Cambridge, 2017, 53(91), 12337-12340

Production Method 24

1124-53-4

151-10-0

829-20-9

Reaction Conditions

1.1 Reagents: Trifluoromethanesulfonic anhydride ,  2-Fluoropyridine Solvents: Dichloromethane ;  -78 °C; 10 min, 0 °C
1.2 0 °C; 0 °C → 40 °C; 1 h, 40 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ;  rt → reflux; 2 h, reflux; reflux → rt

Reference

Metal-Free Intermolecular Coupling of Arenes with Secondary Amides: Chemoselective Synthesis of Aromatic Ketimines and Ketones, and N-Deacylation of Secondary Amides

Huang, Pei-Qiang; et al, Journal of Organic Chemistry, 2016, 81(19), 9020-9027

Production Method 25

21963-22-4

14874-70-5

151-10-0

829-20-9

Reaction Conditions

1.1 Solvents: Dichloromethane ;  48 h, reflux
1.2 Reagents: Sodium hydroxide Solvents: Water ;  pH 7, rt

Reference

Reactions of nitrilium salts with indole and pyrrole and their derivatives in the synthesis of imines, ketones and secondary amines

Giles, Robert G.; et al, Tetrahedron, 2015, 71(39), 7367-7385

Production Method 26

552-41-0

829-20-9

Reaction Conditions

1.1 Solvents: Diethyl ether ,  Methanol

Reference

Action of diazomethane on hydroxy compounds and of diazomethane derivatives on phenanthraquinone

Schonberg, Alexander; et al, Journal of the Chemical Society, 1946, 746, 746-8

Production Method 27

21963-22-4

151-10-0

37181-39-8

829-20-9

Reaction Conditions

Reference

The synthesis and some reactions of N-methylnitrilium trifluoromethanesulfonate salts

Booth, Brian L.; et al, Journal of the Chemical Society, 1980, (23), 1151-3

Production Method 28

91-52-1

88-12-0

829-20-9

Reaction Conditions

1.1 Reagents: Quinone Catalysts: Palladium trifluoroacetate ,  6-Methyl-2,2′-bipyridine Solvents: Dimethylformamide ;  24 h, rt → 120 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  2 h, rt

Reference

Palladium(II)-Catalyzed Decarboxylative Heck Arylations of Acyclic Electron-Rich Olefins with Internal Selectivity

Fardost, Ashkan; et al, Advanced Synthesis & Catalysis, 2014, 356(4), 870-878

Production Method 29

1026990-71-5

89-84-9

829-20-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethyl sulfoxide ;  3 h, rt → 80 °C

Reference

A mechanistic analysis of trimethylanilinium salt degradation: implications for methylation and cross-coupling applications

Washington, Jack B.; et al, ChemRxiv, 2021, 1, 1-14

2',4'-Dimethoxyacetophenone Raw materials

• Methanaminium, N-ethylidyne-
• Ethanone, 1-(2,4-dimethoxyphenyl)-, oxime
• N-Cyclohexylacetamide
• Borate(1-),tetrafluoro-
• 1-(2,4-Dihydroxyphenyl)ethanone 2,2-dimethylhydrazone
• Benzenaminium, 3-bromo-N,N,N-trimethyl-, iodide (1:1)
• Ethanone, 1-(2,4-dimethoxyphenyl)-, dimethylhydrazone
• Methyllithium (1.6M in Diethyl Ether)
• 2',4'-Dihydroxyacetophenone
• 2,4-Dimethoxybenzoic acid
• 1,4-Dimethoxybenzene
• Paeonol
• 2,4-Dimethoxyphenylmethylcarbinol
• 1,3-Dimethoxybenzene
• 1-ethenylpyrrolidin-2-one
• Ethaneselenoic acid, Se-phenyl ester

2',4'-Dimethoxyacetophenone Preparation Products

• 2',4'-Dimethoxyacetophenone (829-20-9)

• 1. An insight into the role of side chains in the microstructure and carrier mobility of high-performance conjugated polymers?
  Jianyao Huang,Dong Gao,Zhihui Chen,Weifeng Zhang Polym. Chem., 2021,12, 2471-2480
• 2. Alumina grafted SBA-15 sustainable bifunctional catalysts for direct cross-coupling of benzylic alcohols to diarylmethanes?
  Chandran Rajendran,Govindaswamy Satishkumar,Charlotte Lang,Eric M. Gaigneaux Catal. Sci. Technol., 2020,10, 2583-2592
• 3. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
• 4. Aggregation, pretransitional behavior, and optical properties in the isotropic phase of lyotropic chromonic liquid crystals studied in high magnetic fields
  Tanya Ostapenko,Peter J. Collings,Samuel N. Sprunt,J. T. Gleeson Soft Matter, 2013,9, 9487-9498
• 5. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone

• 90-24-4(Xanthoxylin)
• 832-58-6(2',4',6'-Trimethoxyacetophenone)
• 23121-32-6(Methylxanthoxylin)
• 3098-67-7(1-(5-acetyl-2,4-dimethoxyphenyl)ethan-1-one)
• 129399-54-8(Ethanone,1-(2,6-dihydroxy-4-methoxy-3,5-dimethylphenyl)-)
• 703-23-1(2-Hydroxy-6-methoxyacetophenone)
• 3602-54-8(2,4-Dihydroxy-6-methoxyacetophenone)
• 2040-04-2(2',6'-Dimethoxyacetophenone)
• 3098-38-2(Ethanone,1,1'-(2,4-dihydroxy-6-methoxy-1,3-phenylene)bis-)
• 14964-98-8(Bancroftinone)