Cas no 82671-03-2 (Ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate)

Ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate is a fluorinated pyridine derivative widely used as a key intermediate in pharmaceutical and agrochemical synthesis. Its structure features reactive chloro and fluoro substituents, enabling selective functionalization for the development of bioactive compounds. The ester group enhances solubility and facilitates further derivatization. This compound is valued for its stability, high purity, and compatibility with cross-coupling reactions, making it suitable for constructing complex heterocyclic frameworks. Its applications include the synthesis of herbicides, fungicides, and active pharmaceutical ingredients (APIs). Strict quality control ensures consistency in research and industrial-scale production.
Ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate structure
82671-03-2 structure
Product Name:Ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate
CAS No:82671-03-2
MF:C8H6Cl2FNO2
MW:238.043143749237
MDL:MFCD09757511
CID:706724
PubChem ID:13210747
Update Time:2025-06-09

Ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate Chemical and Physical Properties

Names and Identifiers

    • Ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate
    • 3-Pyridinecarboxylicacid, 2,6-dichloro-5-fluoro-, ethyl ester
    • ETHYL 2,6-DICHLORO-5-FLUORONICOTINATE
    • 2,6-Dichloro-5-Fluoro-3-Pyridinecarboxylic Acid Ethyl Ester
    • 2,6-Dichloro-5-fluoro-nicotinic acid ethyl ester
    • ethyl 2,6-dichloro-5-fluoro-3-pyridinecarboxylate
    • ethyldichlorofluoronicotinate
    • Ethyl 2,6-dichloro-5-fluoro-3-pyridinecarboxylate (ACI)
    • 2,6-Dichloro-5-fluoronicotinic acid ethyl ester
    • ethyl2,6-dichloro-5-fluoronicotinate
    • DTXSID60528119
    • NC-0751
    • AKOS005073712
    • ethyl 2,6-dichloro-5-fluoro-pyridine-3-carboxylate
    • CS-0169351
    • E83952
    • MFCD09757511
    • J-520677
    • FPPLCOWQBGOFDU-UHFFFAOYSA-N
    • SCHEMBL860929
    • 82671-03-2
    • 3-Pyridinecarboxylic acid, 2,6-dichloro-5-fluoro-, ethyl ester
    • MDL： MFCD09757511
    • Inchi： 1S/C8H6Cl2FNO2/c1-2-14-8(13)4-3-5(11)7(10)12-6(4)9/h3H,2H2,1H3
    • InChI Key： FPPLCOWQBGOFDU-UHFFFAOYSA-N
    • SMILES： O=C(C1C(Cl)=NC(Cl)=C(F)C=1)OCC

Computed Properties

  • Exact Mass: 236.97600
  • Monoisotopic Mass: 236.9759620g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 14
  • Rotatable Bond Count: 3
  • Complexity: 218
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.1
  • Topological Polar Surface Area: 39.2?2

Experimental Properties

  • PSA: 39.19000
  • LogP: 2.70420

Ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate Security Information

  • HazardClass：IRRITANT

Ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate Customs Data

  • HS CODE：2933399090
  • Customs Data：

    China Customs Code:

    2933399090

    Overview:

    2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate Pricemore >>

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Ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate Production Method

Production Method 1

Reaction Conditions
Reference
1,8-Naphthyridine derivatives and their salts
, Japan, , ,

Production Method 2

Reaction Conditions
1.1 Reagents: Sodium ethoxide Solvents: Ethanol
1.2 Solvents: Ethanol
2.1 Reagents: Phosphorus pentachloride
3.1 Reagents: Sulfuric acid
4.1 Reagents: Boron trifluoride etherate
Reference
Pyridonecarboxylic acids as antibacterial agents. VIII. An alternative synthesis of enoxacin via fluoronicotinic acid derivatives
Miyamoto, Teruyuki; et al, Chemical & Pharmaceutical Bulletin, 1987, 35(6), 2280-5

Production Method 3

Reaction Conditions
1.1 Reagents: Phosphorus trichloride
2.1 Reagents: Sulfuric acid Solvents: Water
3.1 Reagents: Thionyl chloride
4.1 Solvents: Dichloromethane ;  rt; 3 - 4 h, rt
Reference
Synthesis and biological activity of fluorine-substituted pyridine-heterocyclic carboxylate compounds
Zheng, Hui; et al, Yingyong Huaxue, 2010, 27(2), 164-168

Production Method 4

Reaction Conditions
1.1 Reagents: Sodium ethoxide ,  Sodium 3-ethoxy-2-fluoro-3-oxoprop-1-en-1-olate Solvents: Ethanol
2.1 Reagents: Phosphorus pentachloride
3.1 Reagents: Sulfuric acid
4.1 Reagents: Boron trifluoride etherate
Reference
Pyridonecarboxylic acids as antibacterial agents. VIII. An alternative synthesis of enoxacin via fluoronicotinic acid derivatives
Miyamoto, Teruyuki; et al, Chemical & Pharmaceutical Bulletin, 1987, 35(6), 2280-5

Production Method 5

Reaction Conditions
1.1 Reagents: Sodium methoxide
2.1 Reagents: Phosphorus trichloride
3.1 Reagents: Sulfuric acid Solvents: Water
4.1 Reagents: Thionyl chloride
5.1 Solvents: Dichloromethane ;  rt; 3 - 4 h, rt
Reference
Synthesis and biological activity of fluorine-substituted pyridine-heterocyclic carboxylate compounds
Zheng, Hui; et al, Yingyong Huaxue, 2010, 27(2), 164-168

Production Method 6

Reaction Conditions
1.1 Solvents: Dichloromethane ;  rt; 3 - 4 h, rt
Reference
Synthesis and biological activity of fluorine-substituted pyridine-heterocyclic carboxylate compounds
Zheng, Hui; et al, Yingyong Huaxue, 2010, 27(2), 164-168

Production Method 7

Reaction Conditions
1.1 Reagents: Boron trifluoride etherate
Reference
Pyridonecarboxylic acids as antibacterial agents. VIII. An alternative synthesis of enoxacin via fluoronicotinic acid derivatives
Miyamoto, Teruyuki; et al, Chemical & Pharmaceutical Bulletin, 1987, 35(6), 2280-5

Production Method 8

Reaction Conditions
Reference
1,8-Naphthyridine derivatives and their salts
, Japan, , ,

Production Method 9

Reaction Conditions
1.1 Reagents: Phosphorus pentachloride
2.1 Reagents: Sulfuric acid
3.1 Reagents: Boron trifluoride etherate
Reference
Pyridonecarboxylic acids as antibacterial agents. VIII. An alternative synthesis of enoxacin via fluoronicotinic acid derivatives
Miyamoto, Teruyuki; et al, Chemical & Pharmaceutical Bulletin, 1987, 35(6), 2280-5

Production Method 10

Reaction Conditions
1.1 Reagents: Sulfuric acid
2.1 Reagents: Boron trifluoride etherate
Reference
Pyridonecarboxylic acids as antibacterial agents. VIII. An alternative synthesis of enoxacin via fluoronicotinic acid derivatives
Miyamoto, Teruyuki; et al, Chemical & Pharmaceutical Bulletin, 1987, 35(6), 2280-5

Production Method 11

Reaction Conditions
1.1 Reagents: Sulfuric acid Solvents: Water
2.1 Reagents: Thionyl chloride
3.1 Solvents: Dichloromethane ;  rt; 3 - 4 h, rt
Reference
Synthesis and biological activity of fluorine-substituted pyridine-heterocyclic carboxylate compounds
Zheng, Hui; et al, Yingyong Huaxue, 2010, 27(2), 164-168

Production Method 12

Reaction Conditions
1.1 Reagents: Thionyl chloride
2.1 Solvents: Dichloromethane ;  rt; 3 - 4 h, rt
Reference
Synthesis and biological activity of fluorine-substituted pyridine-heterocyclic carboxylate compounds
Zheng, Hui; et al, Yingyong Huaxue, 2010, 27(2), 164-168

Ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate Raw materials

Ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate Preparation Products

Ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate Related Literature

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