Cas no 826-62-0 (Nadic anhydride)
Nadic anhydride Chemical and Physical Properties
Names and Identifiers
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- 3a,4,7,7a-Tetrahydro-4,7-methanoisobenzofuran-1,3-dione
- 3,6-ENDOMETHYLENE-(1,2,3,6)-TETRAHYDROCIS-PHTHALIC ANHYDRIDE
- 3,6-ENDOMETHYLENE-1,2,3,6-TETRAHYDROPHTHALIC ANHYDRIDE
- 5-NORBORNENE-2,3-DICARBONIC ANHYDRIDE
- 5-NORBORNENE-2,3-DICARBOXYLIC ANHYDRIDE
- BICYCLO[2.2.1]-5-HEPTENE-2,3-DICARBOXYLIC ANHYDRIDE
- BICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLIC ANHYDRIDE
- CARBIC ANHYDRIDE
- CIS-3,6-ENDO-METHYLENE-TETRAHYDROPHTHALIC ANHYDRIDE
- CIS-5-NORBORNENE-ENDO-2,3-DICARBOXYLIC ANHYDRIDE
- ENDO-CIS-5-NORBORNENE-2,3-DICARBOXYLIC ANHYDRIDE
- ENDO-CIS-BICYCLO [2.2.1]-5-HEPTENE-2,3-DICARBOXYLIC ANHYDRIDE
- ENDO-CIS-HIMIC ANHYDRIDE
- NADIC ANHYDRIDE
- 3,6’-Endomethylene-1,2,3,6-tet
- 3-dione,3a,4,7,7a-tetrahydro-7-methanoisobenzofuran-1
- 7-Methanoisobenzofuran-1,3-dione,3a,4,7,7a-tetrahydro-4
- anhydridkyseliny3,6-endomethylen-delta(sup4)-tetrahydroftalove
- 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydro-
- Bicyclo[2,2,1]5-heptene-2,3-dicarboxylicanhydride
- Himic anhydride
- Nadic anhydrous
- Nickel
- 1,2,3,6-Tetrahydro-3,6-methanophthalic anhydride
- 2-Norbornene-5,6-dicarboxylic anhydride
- Endic anhydride
- Endomethylenetetrahydrophthalic anhydride
- Methylenetetrahydrophthalic anhydride
- Norbornenedicarboxylic acid anhydride
- 3,6-Endomethylenetetrahydrophthalic anhydride
- 5-Norbornene-2,3-dicarboxylic acid anhydride
- Cyclopentadiene-maleic
- 4-oxatricyclo[5.2.1.02,?]dec-8-ene-3,5-dione
- 3a,4,7,7a-Tetrahydro-4,7-methanoisobenzofuran-1,3-dione (ACI)
- 5-Norbornene-2,3-dicarboxylic anhydride (6CI, 8CI)
- 3,6-Methano-4-cyclohexene-1,2-dicarboxylic acid anhydride
- 3,6-Methylene-1,2,3,6-tetrahydrophthalic anhydride
- 4-Oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
- 5,6-Norbornene-2,3-dicarboxylic acid anhydride
- Anhydride 647
- Bicyclo[2.2.1]hept-2-ene-5,6-dicarboxylic anhydride
- Norbornenedicarboxylic anhydride
- NSC 3999
- NSC-102277
- 5-Norbornene-endo-2,3-dicarboxylic anhydride
- endo,3-dicarboxylic anhydride
- Bicyclo[2.2.1]hept-5-ene-exo-2,3-dicarboxylic Anhydride
- 5-norbomene-2,3-dicarboxylic anhydride
- NCGC00254212-01
- WLN: T556/FJ 2AE J BVOV IUTJ
- Bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid endo-cis-anhydride
- Nadic Anhydride (NA)
- FT-0655593
- NSC 102277
- NS00038218
- 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydro-, (3aR,4S,7R,7aS)-rel-
- Anhydrid kyseliny 3,6-endomethylen-.delta.(sup 4)-tetrahydroftalove
- E83026
- SY067019
- Bicyclo[2.2.1hept-5-ene-2-endo,3-endo-dicarboxylic anhydride
- 5-Norbornene-2, cis-exo-
- bicyclo[2. 2. 1]hept-5-ene-2,3-dicarboxylic anhydride
- 4-Oxa-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione
- SB66305
- endo,cis-5-Norbornene-2,3-dicarboxylic anhydride
- endo-5-Norbornene-2,3-dicarboxylic anhydride
- 55636-72-1
- 3a,4,7,7a-tetrahydro-4,7-methano-2-benzofuran-1,3-dione
- NSC-3999
- endo-3,2,3,6-tetrahydrophthalic anhydride
- EINECS 212-557-9
- exo-3,2,3,6-tetrahydrophthalic anhydride
- (3a.alpha.,4.alpha.,7.alpha.,7a.alpha.)-3a,4,7,7a-Tetrahydro-4,7-methano-isobenzofuran-1,3-dione
- SCHEMBL27496
- Bicyclo[2,2,1]5-heptene-2,3-dicarboxylic anhydride
- DTXSID0047456
- NS00079549
- BICYCLO(2.2.1)-HEPT-5-ENE-2,3-DICARBOXYLIC ANHYDRIDE
- cis-3,2,3,6-tetrahydropthalic anhydride
- bicyclo[2.2.1]hept-5-en-2,3-dicarboxylic anhydride
- cis-3,6-Endomethylene-1,2,3,6-tetrahydropthalic anhydride
- FT-0620730
- CAS-826-62-0
- FT-0673051
- NSC3999
- VS-02608
- bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid anhydride
- N0331
- Anhydrid kyseliny 3,6-endomethylen-delta(sup 4)-tetrahydroftalove [Czech]
- AKOS016352932
- 4-oxatricyclo[5.2.1.0,2,6]dec-8-ene-3,5-dione
- NCGC00247985-01
- NSC-110659
- N0767
- J-501160
- 4-OXATRICYCLO[5.2.1.0(2),?]DEC-8-ENE-3,5-DIONE
- 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydro-, (3a.alpha.,4.beta.,7.beta.,7a.alpha.)-
- CS-W017913
- 826-62-0
- CHEMBL268522
- Exo-cis-5-Norbornene-2,3-dicarboxylic anhydride
- Anhydrid kyseliny 3,6-endomethylen-delta(sup 4)-tetrahydroftalove
- NCIOpen2_001832
- NSC110659
- exo-5-Norbornene-2,3-dicarboxylic anhydride
- NSC102277
- 4,7-Methanoisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydro-, (3a.alpha.,4.alpha.,7.alpha.,7a.alpha.)-
- cis-5-Norbornene-exo-2,3-dicarboxylic anhydride
- DTXCID8027456
- 3, 1,2,3,6-tetrahydro-
- 3,6-Endomethylene-.DELTA.4-tetrahydrophthalic anhydride
- 3,6-Endomethylenephthalic anhydride, 1,2,3,6-tetrahydro-
- MFCD00630580
- AKOS000121029
- exo-cis-5-norbornene-2, 3-dicarboxylic anhydride
- EN300-18013
- Bicyclo[2.2.1]-hept-5-ene-2,3-dicarboxylic anhydride
- Tox21_300273
- endo-Himic acid anhydride
- Bicyclo(2.2.1)hept5ene2,3dicarboxylic anhydride
- 4,7Methanoisobenzofuran1,3dione, 3a,4,7,7atetrahydro
- 3,6Endomethylenetetrahydrophthalic anhydride
- 5-Norbornene-2,3-dicarboxylic anhydride (8CI)
- 2Norbornene5,6dicarboxylic anhydride
- 1,3Cyclopentadiene, compd. with 2,5furandione (1:1)
- 1,2,3,6Tetrahydro3,6methanophthalic anhydride
- DB-050505
- exo-3,6-Methylene-1,2,3,6-tetrahydrophthalic anhydride
- STL146298
- 129-64-6
- 3,6Endomethylenephthalic anhydride, 1,2,3,6tetrahydro
- Cyclopentadienemaleic anhydride adduct
- BBL010668
- Anhydrid kyseliny 3,6endomethylendelta(sup 4)tetrahydroftalove
- 3,6Methylene1,2,3,6tetrahydrophthalic anhydride
- (3at,7at)-3a,4,7,7a-tetrahydro-4r,7c-methano-isobenzofuran-1,3-dione
- Nadic anhydride
-
- MDL: MFCD00069013
- Inchi: 1S/C9H8O3/c10-8-6-4-1-2-5(3-4)7(6)9(11)12-8/h1-2,4-7H,3H2
- InChI Key: KNDQHSIWLOJIGP-UHFFFAOYSA-N
- SMILES: O=C1C2C(C3CC2C=C3)C(=O)O1
Computed Properties
- Exact Mass: 164.047
- Monoisotopic Mass: 164.047
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 12
- Rotatable Bond Count: 0
- Complexity: 277
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 4
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: nothing
- XLogP3: 0.7
- Topological Polar Surface Area: 43.4
Experimental Properties
- Color/Form: White or yellowish crystals or powder
- Density: 1.2132 (rough estimate)
- Melting Point: 163.0 to 166.0 deg-C
- Boiling Point: 251.61°C (rough estimate)
- Flash Point: 163.8°C
- Refractive Index: 1.5260 (estimate)
- Solubility: diethyl ether: soluble0.1g/10 mL, clear, colorless
- PSA: 43.37000
- LogP: 0.50810
- Sensitiveness: Easily absorb moisture
- Merck: 1796
- Solubility: Soluble in acetone, ethanol, toluene, ethyl acetate, chloroform, etc., slightly soluble in petroleum ether
Nadic anhydride Security Information
-
Symbol:
- Prompt:dangerous
- Signal Word:Danger
- Hazard Statement: H317,H318,H334
- Warning Statement: P261,P280,P305+P351+P338,P342+P311
- Hazardous Material transportation number:NONH for all modes of transport
- WGK Germany:3
- Hazard Category Code: 41-42/43
- Safety Instruction: 22-24-26-37/39
- FLUKA BRAND F CODES:21
- RTECS:DT5600000
-
Hazardous Material Identification:
Nadic anhydride Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| XI GE MA AO DE LI QI ( SHANG HAI ) MAO YI Co., Ltd. | 14353-250G |
Nadic anhydride |
826-62-0 | 250g |
¥1028.84 | 2023-12-10 | ||
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | N814629-2.5kg |
Nadic anhydrous |
826-62-0 | 99% | 2.5kg |
1,215.00 | 2021-05-17 | |
| TI XI AI ( SHANG HAI ) HUA CHENG GONG YE FA ZHAN Co., Ltd. | N0331-500G |
5-Norbornene-2,3-dicarboxylic Anhydride |
826-62-0 | >97.0%(T) | 500g |
¥270.00 | 2024-04-15 | |
| SHANG HAI SHAO YUAN SHI JI Co., Ltd. | SY031242-25g |
5-Norbornene-2,3-dicarboxylic Anhydride |
826-62-0 | ≥97% | 25g |
¥25.00 | 2024-07-09 | |
| SHANG HAI SHAO YUAN SHI JI Co., Ltd. | SY031242-100g |
5-Norbornene-2,3-dicarboxylic Anhydride |
826-62-0 | ≥97% | 100g |
¥27.00 | 2024-07-09 | |
| SHANG HAI SHAO YUAN SHI JI Co., Ltd. | SY031242-500g |
5-Norbornene-2,3-dicarboxylic Anhydride |
826-62-0 | ≥97% | 500g |
¥119.00 | 2024-07-09 | |
| SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd. | N86550-100g |
3a,4,7,7a-Tetrahydro-4,7-methanoisobenzofuran-1,3-dione |
826-62-0 | 100g |
¥64.0 | 2021-09-08 | ||
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R015247-100g |
Nadic anhydride |
826-62-0 | 99% | 100g |
¥39 | 2024-05-21 | |
| SHANG HAI YI EN HUA XUE JI SHU Co., Ltd. | R015247-500g |
Nadic anhydride |
826-62-0 | 99% | 500g |
¥158 | 2024-05-21 | |
| SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd. | N105699-100g |
Nadic anhydride |
826-62-0 | 99% | 100g |
¥69.90 | 2023-09-01 |
Nadic anhydride Production Method
Production Method 1
Production Method 2
Production Method 3
Production Method 4
Production Method 5
1.2 30 min, rt; 15 min, rt → -20 °C
1.3 30 min, -20 °C; 4 h, -20 °C; -20 °C → 0 °C
1.4 Reagents: Citric acid Solvents: Water ; 0 °C
Production Method 6
Production Method 7
Production Method 8
Production Method 9
2.1 -
Production Method 10
2.1 Solvents: Benzene ; reflux; reflux → rt; 2 h, rt
Nadic anhydride Raw materials
- Dimethyl Maleate
- Dimethyl Bicyclo2.2.1-5-heptene-2,3-dicarboxylate
- 5-Norbornen-2-carboxylic acid
- 2,5-dihydrofuran-2,5-dione
- 4-Cyclopentene-1,3-dione
Nadic anhydride Preparation Products
Nadic anhydride Suppliers
Nadic anhydride Related Literature
-
Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381
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Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
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S. Amaresh,K. Karthikeyan,K. J. Kim,Y. S. Lee RSC Adv., 2014,4, 23107-23115
-
Eunice Y.-L. Hui,Bhimsen Rout,Yaw Sing Tan,Kok-Ping Chan,Charles W. Johannes Org. Biomol. Chem., 2018,16, 389-392
Additional information on Nadic anhydride
Introduction to Nadic Anhydride (CAS No. 826-62-0)
Nadic anhydride, chemically known as Nadic anhydride (CAS No. 826-62-0), is a significant compound in the field of organic synthesis and pharmaceutical applications. This bicyclic anhydride derived from maleic anhydride has garnered considerable attention due to its unique reactivity and utility in various chemical transformations. The compound's structure, consisting of a fused ring system with two carbonyl groups, makes it a versatile intermediate in the synthesis of complex molecules.
The CAS number 826-62-0 provides a unique identifier for this compound, ensuring precise classification and communication within the scientific community. Nadic anhydride is particularly valued for its role in the formation of ester and amide derivatives, which are crucial in the development of pharmaceuticals and specialty chemicals. Its reactivity is harnessed in various synthetic pathways, including Michael additions and cycloadditions, making it a cornerstone in modern organic chemistry.
Recent advancements in the application of Nadic anhydride have highlighted its potential in drug discovery and material science. For instance, studies have demonstrated its efficacy in the synthesis of novel heterocyclic compounds, which exhibit promising biological activities. The compound's ability to undergo regioselective reactions has opened new avenues for designing molecules with specific therapeutic properties. This has been particularly relevant in the development of antiviral and anticancer agents, where precise molecular architecture is essential.
The industrial significance of Nadic anhydride (CAS No. 826-62-0) is further underscored by its use in polymer chemistry. As a diester equivalent, it serves as a monomer or modifier in the production of high-performance polymers. These materials find applications in automotive, aerospace, and electronics industries, where durability and thermal stability are paramount. The compound's incorporation into polymer matrices enhances mechanical strength and resistance to environmental degradation, contributing to the longevity and efficiency of end products.
In academic research, Nadic anhydride continues to be a subject of investigation due to its broad utility and adaptability. Researchers have explored its role in catalytic systems, where it acts as a ligand or co-catalyst in various organic transformations. The compound's ability to facilitate asymmetric reactions has been particularly noteworthy, leading to the synthesis of enantiomerically pure compounds with high pharmaceutical relevance. Such findings underscore the importance of Nadic anhydride in advancing synthetic methodologies.
The pharmaceutical industry has also leveraged Nadic anhydride (CAS No. 826-62-0) for its potential in drug formulation and delivery systems. Its reactivity allows for the creation of prodrugs that can be activated under specific physiological conditions, enhancing bioavailability and therapeutic efficacy. Additionally, the compound's incorporation into nanocarriers has shown promise in targeted drug delivery, reducing side effects while improving treatment outcomes. These innovations highlight the multifaceted role of Nadic anhydride in addressing complex medical challenges.
From a chemical synthesis perspective, Nadic anhydride offers unique advantages due to its stable yet reactive nature. It can be easily manipulated under controlled conditions to yield a wide range of derivatives, making it indispensable in laboratory settings. The compound's compatibility with various solvents and reaction conditions further enhances its practicality in synthetic workflows. This flexibility has made Nadic anhydride a preferred choice for chemists working on complex molecular architectures.
The environmental impact of using Nadic anhydride (CAS No. 826-62-0) has also been a point of interest in recent research. Efforts have been made to develop greener synthetic routes that minimize waste and energy consumption while maintaining high yields. These initiatives align with global trends toward sustainable chemistry practices, ensuring that the use of Nadic anhydride remains environmentally responsible.
In conclusion, Nadic anhydride stands as a pivotal compound with far-reaching applications across multiple sectors. Its role in pharmaceuticals, polymer chemistry, and catalysis underscores its importance as a synthetic building block. As research continues to uncover new uses for this versatile molecule, its significance is poised to grow even further, driving innovation and progress in chemical science.
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