Production Method 1

1193-81-3

823-76-7

Reaction Conditions

1.1 Reagents: Periodic acid (H5IO6) Catalysts: Ruthenium(1+), bis(acetonitrile)bis(2,4-pentanedionato-κO2,κO4)-, (OC-6-21)-, he… (silica-supported) Solvents: Water ;  3 h, 27 °C

Reference

Immobilization of Ru(III) complex on silica: a heterogenized catalyst for selective oxidation of alcohols in water at room temperature

Ganesamoorthy, S.; et al, Tetrahedron Letters, 2013, 54(51), 7035-7039

Production Method 2

1193-81-3

823-76-7

Reaction Conditions

1.1 Reagents: Silica ,  Periodic acid Catalysts: Potassium bromide Solvents: Chloroform ,  Water ;  8.5 h, rt

Reference

A catalytic and transition metal-free method for the chemoselective oxidation of alcohols to their corresponding carbonyl compounds using periodic acid or iodic acid in the presence of a catalytic amount of KBr

Zolfigol, Mohammad Ali; et al, Journal of Molecular Catalysis A: Chemical, 2007, 265(1-2), 272-275

Production Method 3

931-48-6

823-76-7

Reaction Conditions

1.1 Catalysts: Chloro[(isocyano-κC)cyclohexane]gold ,  Potassium tetrakis(pentafluorophenyl)borate Solvents: Methanol ,  Water ;  24 h, rt

Reference

Hydration of alkynes at room temperature catalyzed by gold(I) isocyanide compounds

Xu, Yun; et al, Green Chemistry, 2015, 17(1), 532-537

Production Method 4

932-66-1

823-76-7

Reaction Conditions

1.1 Reagents: Phenylsilane Catalysts: Molybdenum hexacarbonyl Solvents: Tetrahydrofuran

Reference

Silicon hydrides and molybdenum(0) catalyst: a novel approach for conjugate reduction of α,β-unsaturated carbonyl compounds

Keinan, Ehud; et al, Journal of Organic Chemistry, 1987, 52(12), 2576-80

Production Method 5

2863-48-1

823-76-7

Reaction Conditions

1.1 Solvents: Tetrahydrofuran

Reference

Methylsulfinyl carbanion. Formation and application to organic synthesis

Corey, E. J.; et al, Journal of the American Chemical Society, 1965, 87(6), 1345-53

Production Method 6

3483-39-4

823-76-7

Reaction Conditions

1.1 Catalysts: Aluminum(1+), bis(tetrahydrofuran)[5,10,15,20-tetrakis(4-chlorophenyl)-21H,23H-p… Solvents: Tetrahydrofuran ;  18 h, 22 °C
1.2 Reagents: Potassium sodium tartrate Solvents: Water ;  18 h, 22 °C

Reference

Meinwald-type rearrangement of monosubstituted epoxides to methyl ketones using an [Al porphyrin]+[Co(CO)4]- catalyst

Lamb, Jessica R.; et al, Organic Chemistry Frontiers, 2015, 2(4), 346-349

Production Method 7

5913-13-3

823-76-7

Reaction Conditions

1.1 Reagents: Pyridoxal 5′-phosphate ,  1,3-Dimethoxy-2-propanone Catalysts: Aminotransferase Solvents: Water ;  48 h, pH 7, 30 °C

Reference

Enzymatic Racemization of Amines Catalyzed by Enantiocomplementary ω-Transaminases

Koszelewski, Dominik; et al, Chemistry - A European Journal, 2011, 17(1), 378-383

Production Method 8

823-76-7

Reaction Conditions

1.1 Reagents: tert-Butyllithium ,  Hydrogen peroxide ,  (Dimethyl sulfide)trihydroboron Solvents: Water

Reference

Formation of carbon-carbon and carbon-heteroatom bonds via organoboranes and organoborates

Negishi, Ei-Ichi; et al, Organic Reactions (Hoboken, 1985, 33,

Production Method 9

98-89-5

917-54-4

823-76-7

Reaction Conditions

1.1 Reagents: Lithium hydride Solvents: 1,2-Dimethoxyethane ;  10 min, rt; rt → reflux; 2 h, reflux; reflux → 10 °C
1.2 Solvents: Diethyl ether ;  30 min, cooled; 2 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  rt

Reference

Steric and electronically biasing substituent effects on the photoreversibility of novel 3'-, 5'- and 3-substituted indolospirobenzopyrans. Thermal evaluation using 1H NMR spectroscopy and Overhauser enhancement studies

Roxburgh, Craig J.; et al, Dyes and Pigments, 2009, 83(1), 31-50

Production Method 10

98-89-5

917-54-4

823-76-7

Reaction Conditions

1.1 Reagents: Lithium hydride Solvents: 1,2-Dimethoxyethane ;  10 min, rt; 2 h, rt → reflux
1.2 Solvents: Diethyl ether ;  reflux → 10 °C; 30 min, 10 °C
1.3 Reagents: Hydrochloric acid Solvents: Diethyl ether ,  Water ;  2 h, rt

Reference

Photoreversible Zn2+ ion transportation across an interface using ion-chelating substituted photochromic 3,3'-indolospirobenzopyrans: steric and electronic controlling effects

Roxburgh, Craig J.; et al, European Journal of Inorganic Chemistry, 2008, (31), 4951-4960

Production Method 11

917-54-4

10074-42-7

823-76-7

Reaction Conditions

1.1 Solvents: Tetrahydrofuran
1.2 Solvents: Tetrahydrofuran
1.3 Reagents: Hydrochloric acid Solvents: Water

Reference

One-pot synthesis of ketones and aldehydes from carbon dioxide and lithium compounds

Zadel, Guido; et al, Angewandte Chemie, 1992, 104(8), 1070-1

Production Method 12

695-12-5

823-76-7

Reaction Conditions

1.1 Reagents: Cupric chloride ,  Water ,  Oxygen Catalysts: Palladium (clusters with palladium oxide and acetate and nitrate ligands) ,  Titania Solvents: Dimethylacetamide ;  3 h, 80 °C

Reference

Nanoscale palladium cluster immobilized on a TiO2 surface as an efficient catalyst for liquid-phase Wacker oxidation of higher terminal olefins

Choi, Kwang-Min; et al, Chemistry Letters, 2003, 32(2), 180-181

Production Method 13

695-12-5

823-76-7

Reaction Conditions

1.1 Reagents: tert-Butyl hydroperoxide Catalysts: Palladium(2+), bis(acetonitrile)(7-methyl-6-phenylimidazo[1,2-a][1,8]naphthyridi… Solvents: Acetonitrile ;  24 h, 70 °C

Reference

Electronic Asymmetry of an Annelated Pyridyl-Mesoionic Carbene Scaffold: Application in Pd(II)-Catalyzed Wacker-Type Oxidation of Olefins

Saha, Sayantani; et al, ACS Catalysis, 2020, 10(19), 11385-11393

Production Method 14

695-12-5

823-76-7

Reaction Conditions

1.1 Reagents: Cuprous chloride ,  Oxygen Catalysts: Palladium chloride Solvents: Dimethylformamide ,  Water

Reference

Silicon-terminated Domino-Heck-Reaktions and Enantioselective Syntheses

Raschke, Thomas, 1996, , ,

Production Method 15

98-86-2

823-76-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Ruthenium
1.2 Catalysts: Calcium hydroxide ,  Copper oxide (CuO) ,  Basic copper carbonate

Reference

Coordination Chemistry of Novel Scorpionate Ligands Based on 3-Cyclohexylpyrazole and 3-Cyclohexyl-4-bromopyrazole

Trofimenko, Swiatoslaw; et al, Inorganic Chemistry, 2002, 41(7), 1889-1896

Production Method 16

119577-15-0

823-76-7

Reaction Conditions

1.1 Reagents: Nickel dichloride ,  Sodium borohydride Solvents: Methanol ;  45 min, rt
1.2 Reagents: Methanol

Reference

Nickel boride mediated cleavage of 1,3-oxathiolanes: a convenient approach to deprotection and reduction

Khurana, Jitender M.; et al, Monatshefte fuer Chemie, 2016, 147(6), 1113-1116

Production Method 17

155498-77-4

823-76-7

Reaction Conditions

1.1 Reagents: 1,3-Dibromo-5,5-diethyl-2,4,6(1H,3H,5H)-pyrimidinetrione Solvents: Dichloromethane ;  8.5 h, rt

Reference

Mono- and dibromo-5,5-diethylbarbituric acids for cleavage of trimethylsilyl ethers

Khazaei, Ardeshir; et al, Journal of the Brazilian Chemical Society, 2007, 18(1), 239-242

Production Method 18

823-76-7

Reaction Conditions

1.1 Reagents: Methane, tetrachloro-, compd. with aluminum bromide (AlBr3) (1:2) Solvents: Dibromomethane
1.2 -
1.3 -
1.4 Reagents: Ethanol
1.5 Reagents: Water

Reference

A new efficient and selective synthesis of ketones from alkanes or cycloalkanes, CO, and silanes in the presence of aprotic superacids

Akhrem, I. S.; et al, Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, 1998, 47(5), 918-923

Production Method 19

823-76-7

Reaction Conditions

1.1 Catalysts: Sodium(1+), bis(N,N-dimethylformamide-κO)(6,7,9,10,17,18,20,21-octahydrodibenzo[… Solvents: Acetonitrile ;  48 h, 25 °C
1.2 Reagents: Formaldehyde ,  Hydrochloric acid Solvents: Tetrahydrofuran ,  Water ;  1 h, 25 °C

Reference

Decatungstate Catalyzed Photochemical Acetylation of C(sp3)-H Bonds

Liu, Qinglong; et al, Organic Letters, 2022, 24(43), 7983-7987

Production Method 20

15681-48-8

2719-27-9

823-76-7

Reaction Conditions

1.1 Solvents: Diethyl ether

Reference

Methyl and n-alkyl ketones from carboxylic acid chlorides and organocopper reagents

Posner, Gary H.; et al, Tetrahedron Letters, 1970, (53), 4647-50

Production Method 21

106353-55-3

823-76-7

Reaction Conditions

1.1 Reagents: Acetic acid Solvents: Water

Reference

Enamines. Part 44. 2-Acyl-1,1-diamino-ethenes. A new source of methylketones, β-keto amides and β-keto esters

Armati, Antonella; et al, Synthesis, 1986, (7), 573-6

Production Method 22

1193-81-3

823-76-7

Reaction Conditions

1.1 Reagents: Hydrogen peroxide Catalysts: Tetracosa-μ-oxoundecaoxo[μ12-[phosphato(3-)-κO:κO:κO:κO′:κO′:κO′:κO′′:κO′′:κO′′:… (supported on Dowex 22) Solvents: Water ;  2 h, reflux

Reference

Zinc substituted Keggin-type polyoxometalate on Dowex: a green heterogeneous catalyst for oxidation of alcohols in water

Aghayi, Mehdi; et al, Journal of the Iranian Chemical Society, 2020, 17(11), 2895-2900

Production Method 23

931-48-6

823-76-7

Reaction Conditions

1.1 Catalysts: Potassium tetrakis(pentafluorophenyl)borate ,  [1,3-Bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene]chlorog… Solvents: Methanol ,  Water ;  20 min, 25 °C

Reference

Room-Temperature Hydration of Alkynes Catalyzed by Different Carbene Gold Complexes and their Precursors

Xu, Yun; et al, ChemCatChem, 2016, 8(1), 262-267

Production Method 24

931-48-6

823-76-7

Reaction Conditions

1.1 Catalysts: [1,3-Bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene](1,1,1-… Solvents: Benzene-d6 ,  Water ;  250 min, 40 °C

Reference

Substrate selectivity in the alkyne hydration mediated by NHC-Au(I) controlled by encapsulation of the catalyst within a hydrogen bonded hexameric host

Cavarzan, Alessandra; et al, Catalysis Science & Technology, 2013, 3(11), 2898-2901

Production Method 25

932-66-1

823-76-7

Reaction Conditions

1.1 Reagents: Phenylsilane Catalysts: Molybdenum hexacarbonyl Solvents: Tetrahydrofuran

Reference

Ionic and organometallic-catalyzed organosilane reductions

Larson, Gerald L.; et al, Organic Reactions (Hoboken, 2008, 71, 1-737

Production Method 26

932-66-1

823-76-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide Catalysts: Glucose ,  NADPH ,  Glucose dehydrogenase Solvents: Cyclohexane ,  Water ,  Polyethylene glycol ;  110 h, pH 7.2, rt

Reference

The Organic-Synthetic Potential of Recombinant Ene Reductases: Substrate-Scope Evaluation and Process Optimization

Ress, Tina; et al, ChemCatChem, 2015, 7(8), 1302-1311

Production Method 27

3483-39-4

823-76-7

Reaction Conditions

1.1 Catalysts: [1,8-Bis[3-[(3,4-η)-3-buten-1-yl]-2,3-dihydro-1H-imidazol-1-yl-κC2]-3,6-bis(1,1-… (with LiBr and LiCl) Solvents: Tetrahydrofuran ,  Benzene-d6 ;  5 h, rt

Reference

Regio- and chemoselective rearrangement of terminal epoxides into methyl alkyl and aryl ketones

Tian, Yingying; et al, Chemical Communications (Cambridge, 2018, 54(80), 11340-11343

Production Method 28

2815-35-2

823-76-7

Reaction Conditions

Reference

Formation and photochemical rearrangement of β-oxosulfoxonium ylides

Corey, E. J.; et al, Journal of the American Chemical Society, 1964, 86(8), 1640-1

Production Method 29

2863-49-2

823-76-7

Reaction Conditions

Reference

Formation and photochemical rearrangement of β-oxosulfoxonium ylides

Corey, E. J.; et al, Journal of the American Chemical Society, 1964, 86(8), 1640-1

Production Method 30

98-89-5

917-54-4

823-76-7

Reaction Conditions

1.1 Solvents: Diethyl ether

Reference

Methyl ketones from carboxylic acids: cyclohexyl methyl ketone

Bare, Thomas M.; et al, Organic Syntheses, 1969, 49, 81-5

Production Method 31

98-86-2

823-76-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Butylamine (N-(polystyrene)-N,N-dibutyl-1-butanaminium chloride [hyperbranched pol…) ,  Ruthenium Solvents: Water ;  1 h, 30 atm, 30 °C

Reference

Transition metal nanoparticles stabilized by ammonium salts of hyperbranched polystyrene: effect of metals on catalysis of the biphasic hydrogenation of alkenes and arenes

Gao, Lei; et al, Tetrahedron, 2015, 71(37), 6414-6423

Production Method 32

98-86-2

823-76-7

Reaction Conditions

Reference

Exceedingly mild, selective and stereospecific phase-transfer-catalyzed hydrogenation of arenes

Januszkiewicz, Krzysztof R.; et al, Organometallics, 1983, 2(8), 1055-7

1-cyclohexylethan-1-one Raw materials

• Vinylcyclohexane (Stabilized by TBC)
• (R)-(-)-1-Cyclohexylethylamine
• 2-cyclohexyloxirane
• 1-Cyclohexyl-2-methanesulfonyl-ethanone
• Cyclohexane, [1-[(trimethylsilyl)oxy]ethyl]-
• 2-cyclohexyl-N,N-dimethyl-2-oxoethanesulfonamide
• Ethynylcyclohexane
• 1-Acetyl-1-cyclohexene
• Cyclohexanecarboxylic acid
• Methyllithium (1.6M in Diethyl Ether)
• Lithium;cyclohexane
• Lithium dimethylcuprate
• Ethanone, 1-cyclohexyl-2-(methylsulfinyl)-
• cyclohexanecarbonyl chloride
• Acetophenone
• 1,3-Oxathiolane, 2-cyclohexyl-2-methyl-
• 1-Cyclohexylethanol

1-cyclohexylethan-1-one Preparation Products

• 1-cyclohexylethan-1-one (823-76-7)

• 1. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090
• 2. Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides?
  Chen-Yu Chien,Sheng-Sheng Yu Chem. Commun., 2020,56, 11949-11952
• 3. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 4. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 5. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Acids/Esters
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

• 111003-06-6(Cyclohexanone, 2,4-dimethyl-, (2R-trans)-)
• 63079-52-7(TRICYCLO[4.4.1.13,9]DODECANONE)
• 107708-90-7(1,6(2H,5H)-Naphthalenedione, hexahydro-, cis-)
• 109785-15-1(Cyclohexanone, 2,6-dimethyl-, (2R-trans)-)
• 104372-36-3(BICYCLO[5.3.1]UNDECAN-11-ONE, (1R*,7R*)-)
• 63902-06-7(TRICYCLO[4.3.1.13,8]UNDECANE-2,7-DIONE, (1R)-)
• 106900-08-7(Tricyclo[5.3.1.13,9]dodecane-2,8-dione)
• 107018-21-3(Bicyclo[9.3.1]pentadecan-12-one, 14-methyl-)
• 105314-23-6(1,4-Cyclohexanedione, 2-pentadecyl-)
• 107018-23-5(Bicyclo[9.3.1]pentadecan-12-one, 14-ethyl-)