Production Method 1

822-87-7

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Carbon tetrachloride ,  Water ;  20 - 25 °C

Reference

Synthesis of 2-halogenated cyclic ketones

Kashparov, V. P.; et al, Izvestiya Vysshikh Uchebnykh Zavedenii, 2008, (5), 58-60

Production Method 2

822-87-7

Reaction Conditions

1.1 Reagents: 1H-Imidazolium, 1-methyl-3-octyl-, (trichloride) (1:1) ;  30 min, 0 °C

Reference

Alkylimadazolium chloride: a medium of chlorine absorption and chlorination

Shi, Shenyi; et al, Youji Huaxue, 2011, 31(2), 227-230

Production Method 3

61382-76-1

822-87-7

Reaction Conditions

1.1 Catalysts: Lead tetraacetate ,  Calcium chloride Solvents: Methanol ;  22 °C

Reference

Lead(IV) Acetate1

Mihailovic, Mihailo Lj.; et al, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, ,

Production Method 4

4065-81-0

822-87-7

Reaction Conditions

1.1 Reagents: Chlorosuccinimide Catalysts: Iridium, di-μ-chlorodichlorobis[(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopen… Solvents: Tetrahydrofuran ,  Water ;  24 h, rt

Reference

Iridium-Catalyzed 1,3-Hydrogen Shift/Chlorination of Allylic Alcohols

Ahlsten, Nanna; et al, Angewandte Chemie, 2013, 52(24), 6273-6276

Production Method 5

822-87-7

Reaction Conditions

1.1 Reagents: Piperidine, lithium salt (1:1) Solvents: Diethyl ether ,  Tetrahydrofuran ;  -78 °C

Reference

Lithium piperidide

Snieckus, Victor; et al, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, 1, 1-2

Production Method 6

6651-36-1

822-87-7

Reaction Conditions

1.1 Reagents: Cupric chloride Solvents: Dimethylformamide

Reference

Syntheses of α-chloroketones by reaction of silyl enol ethers with copper(II) chloride and iron(III) chloride

Ito, Yoshihiko; et al, Journal of Organic Chemistry, 1980, 45(10), 2022-4

Production Method 7

822-87-7

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Dichloromethane ,  Water

Reference

Ring-Fused Cyclopropanone N,O-Acetals. Electrochemical Preparation and Their Reactivities under Acidic Conditions

Chiba, Toshiro; et al, Journal of Organic Chemistry, 1999, 64(7), 2516-2519

Production Method 8

822-87-7

Reaction Conditions

1.1 Reagents: Chlorotrimethylsilane ,  Chromium trioxide Solvents: Carbon tetrachloride

Reference

Oxidation of olefins using chromic anhydride-chlorotrimethylsilane. A convenient synthesis of α-chloro ketones

Lee, Jong Gun; et al, Tetrahedron Letters, 1989, 30(2), 193-6

Production Method 9

822-87-7

Reaction Conditions

Reference

Product class 6: α-hetero-substituted ketones

Suffert, J., Science of Synthesis, 2005, 26, 869-969

Production Method 10

162147-89-9

822-87-7

Reaction Conditions

1.1 Reagents: Ethylmagnesium bromide Solvents: Tetrahydrofuran
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

Ligand exchange reaction of sulfoxides in organic synthesis: a new synthesis of α-chloro ketones from carbonyl compounds with one-carbon homologation

Satoh, Tsuyoshi; et al, Tetrahedron, 1995, 51(3), 703-10

Production Method 11

1125-99-1

822-87-7

Reaction Conditions

1.1 Reagents: Hexachloroacetone Solvents: Benzene ;  30 min, 0 °C; 0 °C → rt; 1 h, rt
1.2 Reagents: Acetic acid ,  Sodium acetate Solvents: Water ;  1 h, reflux

Reference

Heterolytic and homolytic reactions of polyhalogenated carbonyl compounds

Laskovics, Frederick Mark, 1977, , ,

Production Method 12

1125-99-1

822-87-7

Reaction Conditions

1.1 Solvents: Diethyl ether
2.1 Reagents: Phosphoric acid

Reference

Halogenation of enamines - synthesis of β-halo iminium halides

Seufert, Walter; et al, Chemische Berichte, 1979, 112(5), 1670-6

Production Method 13

822-87-7

Reaction Conditions

1.1 Reagents: Mercuric chloride ,  Iodine Solvents: Dichloromethane

Reference

Mercury(II) chloride-iodine. A useful reagent for the direct and regiospecific synthesis of α-iodo carbonyl compounds

Barluenga, Jose; et al, Synthesis, 1986, (8), 678-80

Production Method 14

61382-76-1

822-87-7

Reaction Conditions

1.1 Reagents: Lead tetraacetate ,  Calcium chloride Solvents: Methanol ;  rt

Reference

Lead(IV) acetate

Mihailovic, Mihailo Lj.; et al, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2005, 1, 1-8

Production Method 15

822-87-7

Reaction Conditions

1.1 Reagents: Methanol ,  Dimethyl sulfoxide ,  Oxalyl chloride ,  Triethylamine Solvents: Dichloromethane

Reference

Reaction of epoxides with activated DMSO reagent. General method for synthesis of α-chloro carbonyl compounds: application in asymmetric synthesis of (3S)-2,3-oxidosqualene

Raina, Sushil; et al, Tetrahedron, 1995, 51(8), 2467-76

Production Method 16

822-87-7

Reaction Conditions

1.1 Catalysts: Methane, 1,1′-thiobis-, compd. with chlorine (1:1) Solvents: Dichloromethane
1.2 Catalysts: Triethylamine

Reference

Dimethyl Sulfide-Chlorine

Murray, William V., e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, ,

Production Method 17

2562-37-0

822-87-7

Reaction Conditions

1.1 Reagents: Toluene Catalysts: Titanium tetrachloride Solvents: Dichloromethane ;  rt

Reference

Titanium(IV) chloride

Gundersen, Lise-Lotte; et al, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2007, 1, 1-26

Production Method 18

41055-91-8

822-87-7

Reaction Conditions

Reference

Convenient preparative method of α-chloroketones

Kuwajima, Isao; et al, Chemistry Letters, 1973, (2), 197-200

Production Method 19

10468-26-5

822-87-7

Reaction Conditions

1.1 Reagents: Hexachloroacetone Solvents: Acetonitrile ;  30 min, 0 °C; 0 °C → rt; 1 h, rt
1.2 Reagents: Acetic acid ,  Sodium acetate Solvents: Water ;  1 h, reflux

Reference

Heterolytic and homolytic reactions of polyhalogenated carbonyl compounds

Laskovics, Frederick Mark, 1977, , ,

Production Method 20

1561-86-0

822-87-7

Reaction Conditions

1.1 Catalysts: Graphite ,  Ammonium tungsten hydroxide oxide ((NH4)6W6(OH)7O17) Solvents: Water ;  15 min, rt
1.2 Reagents: Hydrogen peroxide Solvents: Water ;  rt; 11 h, rt → 70 °C

Reference

Ammonium Tungstate as an Effective Catalyst for Selective Oxidation of Alcohols to Aldehydes or Ketones with Hydrogen Peroxide under Water - A Synergy of Graphene Oxide

Fu, Huihui; et al, Synlett, 2018, 29(4), 447-451

Production Method 21

822-87-7

Reaction Conditions

1.1 Catalysts: Levulinic acid ,  Hydrochloric acid ,  Water ;  4 h, rt → 75 °C

Reference

Conversion of α,α'-dichlorodiazene dioxides using levulinic acid under solvent-free conditions to α-chloroketones through a three-step domino process

Vimala, B. C.; et al, Journal of Chemical Sciences (Bangalore, 2009, 121(6), 1011-1015

Production Method 22

6651-36-1

822-87-7

Reaction Conditions

1.1 Reagents: Sulfuryl chloride ,  Sulfuryl chloride fluoride

Reference

Synthetic methods and reactions. 123. Preparation of α-chloro ketones from enol silyl ethers with sulfuryl chloride fluoride and sulfuryl chloride

Olah, George A.; et al, Journal of Organic Chemistry, 1984, 49(11), 2032-4

Production Method 23

81447-34-9

822-87-7

Reaction Conditions

1.1 Reagents: Cesium chloride Catalysts: Fluorotrimethylsilane Solvents: 1,1,1,3,3,3-Hexafluoro-2-propanol ;  3 h, 23 °C

Reference

Development of a generic activation mode: nucleophilic α-substitution of ketones via oxy-allyl cations

Vander Wal, Mark N.; et al, Chemical Science, 2013, 4(8), 3075-3079

Production Method 24

822-87-7

Reaction Conditions

Reference

Metal-catalyzed organic photoreactions. One-step synthesis of chlorinated ketones from olefins by the photo-oxidation in the presence of iron(III) chloride

Murayama, Eigoro; et al, Chemistry Letters, 1978, (2), 161-4

Production Method 25

54494-41-6

822-87-7

Reaction Conditions

1.1 Reagents: Hydrochloric acid ,  Water Solvents: Water

Reference

Synthesis and thermolysis of 2-amino-1-cycloalkenylsulfonium salts

Vilsmaier, Elmar; et al, Chemische Berichte, 1979, 112(8), 2997-3006

Production Method 26

108-93-0

822-87-7

Reaction Conditions

1.1 Reagents: Trichloroisocyanuric acid Catalysts: Tempo Solvents: Dichloromethane ;  rt; 10 min, rt
1.2 Reagents: Methanol ;  rt; 2 h, rt

Reference

Direct Conversion of Alcohols to α-Chloro Aldehydes and α-Chloro Ketones

Jing, Yuanyuan; et al, Organic Letters, 2014, 16(18), 4932-4935

Production Method 27

1424-22-2

822-87-7

Reaction Conditions

Reference

Product class 6: α-hetero-substituted ketones

Suffert, J., Science of Synthesis, 2005, 26, 869-969

Production Method 28

1424-22-2

822-87-7

Reaction Conditions

1.1 Reagents: Sodium chloride Catalysts: Lead tetraacetate

Reference

Lead(IV) acetate/metal halide reagents; I. Synthesis of α-haloketones

Motohashi, Shigeyasu; et al, Synthesis, 1982, (12), 1021-3

Production Method 29

822-87-7

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride Solvents: Acetonitrile ,  Sulfolane ;  10 h, reflux; cooled
1.2 Reagents: Water Solvents: Diethyl ether ;  cooled

Reference

A new approach to the synthesis of α-chlorocycloalkanones

Li, Xing Hai; et al, Chinese Chemical Letters, 2007, 18(12), 1476-1478

2-chlorocyclohexan-1-one Raw materials

• 1-Pyrrolidino-1-cyclohexene
• Morpholine, 4-(6-chloro-1-cyclohexen-1-yl)-
• 1-Cyclohexen-1-ol
• 1-Cyclohexenyl Acetate
• 1-Nitro-Cyclohexene
• Cyclopentanol, 1-[dichloro(phenylsulfinyl)methyl]-
• Cyclopentanol, 1-(dichloromethyl)-
• Cyclohexanone, 2-[[(4-methylphenyl)sulfonyl]oxy]-
• Cyclohexanol
• 1-(Trimethylsiloxy)cyclohexene
• 2-Chlorocyclohexanol
• Cyclohexene, 1-propoxy-
• Benzenamine, N-1-cyclohexen-1-yl-N-methyl-

2-chlorocyclohexan-1-one Preparation Products

• 2-chlorocyclohexan-1-one (822-87-7)

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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone

• 30418-63-4(Cyclohexanone,2,6-dichloro-)
• 35951-28-1(2-Chlorocyclododecanone)
• 66241-39-2(3-Octanone, 2-chloro-)
• 932-23-0(1,3-Cyclohexanedione,2-chloro-)
• 84098-60-2(2-Hexanone,3,6-dichloro-)
• 24251-77-2(2-Octanone, 3-chloro-)
• 19995-88-1(2,6-Heptanedione,3-chloro-)
• 101251-85-8(4-Octanone, 3-chloro-)
• 4828-34-6(2-chlorocyclooctanone)
• 908104-94-9(Cyclohexanone, 2,4-dichloro-)