Production Method 1

88-65-3

82082-50-6

Reaction Conditions

1.1 Reagents: Triethylamine ,  Isobutyl chloroformate Solvents: Dichloromethane ;  0 °C; 15 min, 0 °C
1.2 0 °C; rt

Reference

Practical Synthesis of Phenanthrid-inones by Palladium-Catalyzed One-Pot C-C and C-N Coupling Reaction: Extending the Substrate Scope to o-Chlorobenzamides

Liu, Hailong; et al, European Journal of Organic Chemistry, 2016, 2016(2), 389-393

Production Method 2

82082-50-6

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane

Reference

Construction of Functionalized Heterocycles by Palladium- Catalyzed Domino Reactions with Strained Alkenes

Thansandote, Praew Petcharat, 2010, , 72(7),

Production Method 3

82082-50-6

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  overnight, rt
1.2 Reagents: Ammonium chloride Solvents: Water ;  rt

Reference

Palladium-Catalyzed Annulation of Haloanilines and Halobenzamides Using Norbornadiene as an Acetylene Synthon: A Route to Functionalized Indolines, Isoquinolinones, and Indoles

Thansandote, Praew; et al, Journal of Organic Chemistry, 2009, 74(4), 1673-1678

Production Method 4

82082-50-6

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  25 °C; 18 h, 25 °C
1.2 Reagents: Ammonium chloride Solvents: Water ;  25 °C

Reference

Ligand-Induced Regioselectivity in Metal-Catalyzed Aryne Reactions Using Borylaryl Triflates as Aryne Precursors

Denman, Brylon N.; et al, Organometallics, 2023, 42(10), 859-864

Production Method 5

82082-50-6

Reaction Conditions

1.1 Reagents: 1,8-Diazabicyclo[5.4.0]undec-7-ene Solvents: Acetonitrile ;  4 h, rt

Reference

Synthesis of N-Cbz Amides and Their Applications in the Transamidation Reactions at Room Temperature

Sureshbabu, Popuri; et al, Asian Journal of Organic Chemistry, 2022, 11(5),

Production Method 6

6630-33-7

82082-50-6

Reaction Conditions

1.1 Reagents: Chlorosuccinimide Solvents: Acetonitrile ;  3 h, rt
1.2 Reagents: tert-Butyl hydroperoxide Catalysts: Azobisisobutyronitrile Solvents: Water ;  24 h, 80 °C

Reference

AIBN-initiated metal free amidation of aldehydes using N-chloroamines

Vanjari, Rajeshwer; et al, Green Chemistry, 2014, 16(1), 351-356

Production Method 7

4001-73-4

100-52-7

82082-50-6

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Nickel ,  Silica Solvents: Toluene ;  24 h, 50 bar, 135 °C

Reference

Reductive N-alkylation of primary amides using nickel-nanoparticles

Murugesan, Kathiravan; et al, Tetrahedron, 2021, 102,

Production Method 8

610-94-6

82082-50-6

Reaction Conditions

1.1 Catalysts: (T-4)-(N,N-Diethylbenzenamine)triiodoboron Solvents: Benzene ;  80 °C

Reference

Boron Triiodide

Ronald, Rob, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, ,

Production Method 9

4001-73-4

82082-50-6

Reaction Conditions

1.1 Catalysts: Triphenylphosphine ,  Cobalt chloride (CoCl2) Solvents: 2,2-Dimethylpropanenitrile ;  24 h, 135 °C

Reference

A Versatile Cobalt Catalyst for Secondary and Tertiary Amide Synthesis from Various Carboxylic Acid Derivatives

Kim, Se Eun; et al, Asian Journal of Organic Chemistry, 2016, 5(2), 222-231

Production Method 10

583-55-1

82082-50-6

Reaction Conditions

1.1 Reagents: Sodium carbonate Catalysts: (SP-4-3)-[2-[[3,5-Bis(1,1-dimethylethyl)-1H-pyrazol-1-yl-κN2]methyl]-1-ethyl-1H-… ;  24 h, 2 MPa, 110 °C

Reference

Carbonylation with the new nitrogen bidentate palladium catalysts

Shi, Li-jun; et al, Fenzi Cuihua, 2011, 25(4), 289-294

Production Method 11

67460-09-7

82082-50-6

Reaction Conditions

1.1 Catalysts: (T-4)-(N,N-Diethylbenzenamine)triiodoboron Solvents: Benzene ;  80 °C

Reference

Boron Triiodide

Ronald, Rob, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, ,

Production Method 12

925706-33-8

82082-50-6

Reaction Conditions

1.1 Catalysts: (T-4)-(N,N-Diethylbenzenamine)triiodoboron Solvents: Benzene ;  80 °C

Reference

Boron Triiodide

Ronald, Rob, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, ,

Production Method 13

88-65-3

82082-50-6

Reaction Conditions

1.1 Reagents: Oxalyl chloride Catalysts: Dimethylformamide Solvents: Benzene ;  30 min, rt
1.2 Reagents: Triethylamine Solvents: Dichloromethane ;  rt; 60 min, rt

Reference

Microwave assisted copper-free Sonogashira coupling/5-exo-dig cycloisomerization domino reaction: access to 3-(phenylmethylene)isoindolin-1-ones and related heterocycles

Hellal, Malik; et al, Tetrahedron Letters, 2011, 52(42), 5508-5511

Production Method 14

88-65-3

82082-50-6

Reaction Conditions

1.1 Reagents: Thionyl chloride Catalysts: Dimethylformamide ;  rt; 3 h, reflux
1.2 Solvents: Tetrahydrofuran ;  0 °C; 16 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  0 °C

Reference

An Ullmann N-arylation/2-amidation cascade by self-relay copper catalysis: one-pot synthesis of indolo[1,2-a]quinazolinones

Abe, Takumi; et al, Organic Chemistry Frontiers, 2017, 4(11), 2124-2127

Production Method 15

79985-00-5

82082-50-6

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  rt; rt → 0 °C; 5 min, 0 °C
1.2 0 °C; 0 °C → rt; 2 h, rt

Reference

Domino Heck-aza-Michael reactions: a one-pot, sequential three-component approach to 1,1-dioxido-1,2-benzisothiazoline-3-acetic acid

Rolfe, Alan; et al, European Journal of Organic Chemistry, 2008, (31), 5254-5262

Production Method 16

2042-37-7

140-11-4

82082-50-6

Reaction Conditions

1.1 Catalysts: Chlorosulfonic acid (silica gel supported) ;  120 min, 100 °C

Reference

Efficient and Green Ritter Reaction for the Synthesis of N-(t-Butyl)- and N-Benzylamides from t-Butyl and Benzyl Acetates

Nasr-Esfahani, Masoud; et al, Organic Preparations and Procedures International, 2016, 48(4), 321-327

Production Method 17

622-79-7

88-65-3

82082-50-6

Reaction Conditions

1.1 Reagents: Triphenylphosphine ;  rt; 15 min, 180 °C

Reference

Solvent-free protocol for amide bond formation via trapping of nascent phosphazenes with carboxylic acids

Sathishkumar, Murugan; et al, Tetrahedron Letters, 2011, 52(22), 2830-2833

Production Method 18

6630-33-7

82082-50-6

Reaction Conditions

1.1 Reagents: Hydroxyamine hydrochloride Catalysts: Triphenylphosphine ,  Cobalt chloride (CoCl2) Solvents: p-Xylene ;  24 h, 135 °C

Reference

A Versatile Cobalt Catalyst for Secondary and Tertiary Amide Synthesis from Various Carboxylic Acid Derivatives

Kim, Se Eun; et al, Asian Journal of Organic Chemistry, 2016, 5(2), 222-231

Production Method 19

134419-77-5

82082-50-6

Reaction Conditions

1.1 Reagents: Lithium tert-butoxide Solvents: Dichloromethane ;  5 min, rt
1.2 2 - 6 h, rt

Reference

Base-promoted amide synthesis from aliphatic amines and ynones as acylation agents through C-C bond cleavage

Cheng, Guolin; et al, Chemical Communications (Cambridge, 2018, 54(14), 1726-1729

Production Method 20

2042-37-7

82082-50-6

Reaction Conditions

1.1 Reagents: Water Catalysts: Triphenylphosphine ,  Cobalt chloride (CoCl2) Solvents: 2,2-Dimethylpropanenitrile ;  24 h, 135 °C

Reference

A Versatile Cobalt Catalyst for Secondary and Tertiary Amide Synthesis from Various Carboxylic Acid Derivatives

Kim, Se Eun; et al, Asian Journal of Organic Chemistry, 2016, 5(2), 222-231

Production Method 21

610-94-6

82082-50-6

Reaction Conditions

1.1 Catalysts: (T-4)-Dichlorobis(triphenylphosphine)cobalt Solvents: p-Xylene ;  24 h, 120 °C

Reference

A Versatile Cobalt Catalyst for Secondary and Tertiary Amide Synthesis from Various Carboxylic Acid Derivatives

Kim, Se Eun; et al, Asian Journal of Organic Chemistry, 2016, 5(2), 222-231

Production Method 22

807365-00-0

82082-50-6

Reaction Conditions

1.1 Solvents: Dichloromethane ;  10 min, rt; 5 min, 80 °C

Reference

Microwave-Assisted Acylation of Amines, Alcohols, and Phenols by the Use of Solid-Supported Reagents (SSRs)

Petricci, Elena; et al, Journal of Organic Chemistry, 2004, 69(23), 7880-7887

Production Method 23

34158-72-0

82082-50-6

Reaction Conditions

1.1 Catalysts: Triphenylphosphine ,  Cobalt chloride (CoCl2) Solvents: 2,2-Dimethylpropanenitrile ;  24 h, 135 °C

Reference

A Versatile Cobalt Catalyst for Secondary and Tertiary Amide Synthesis from Various Carboxylic Acid Derivatives

Kim, Se Eun; et al, Asian Journal of Organic Chemistry, 2016, 5(2), 222-231

Production Method 24

6091-64-1

82082-50-6

Reaction Conditions

1.1 Catalysts: (T-4)-(N,N-Diethylbenzenamine)triiodoboron Solvents: Benzene ;  80 °C

Reference

Boron Triiodide

Ronald, Rob, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, ,

Production Method 25

82082-50-6

Reaction Conditions

1.1 Reagents: Sodium azide Solvents: Acetone ,  Water ;  24 h, rt
2.1 Reagents: Triphenylphosphine ;  rt; 15 min, 180 °C

Reference

Solvent-free protocol for amide bond formation via trapping of nascent phosphazenes with carboxylic acids

Sathishkumar, Murugan; et al, Tetrahedron Letters, 2011, 52(22), 2830-2833

N-Benzyl 2-bromobenzamide Raw materials

• 2-Bromobenzonitrile
• Methyl 2-bromobenzoate
• 2-Bromobenzamide
• 2-Propyn-1-one, 1-(2-bromophenyl)-3-phenyl-
• α-Azidotoluene
• Benzoyl bromide, 2-bromo-
• 2-Bromobenzoic acid
• 2-Bromobenzaldehyde
• Benzoic acid, 2-bromo-, 2-[(4-hydroxybutyl)thio]-6-methyl-4-pyrimidinyl ester
• Benzyl 2-bromobenzoate
• Benzoic acid, 2-bromo-, butyl ester
• Ethyl 2-bromobenzoate
• 2-Bromoiodobenzene
• Benzaldehyde
• 2-Bromobenzaldoxime
• Benzyl acetate

N-Benzyl 2-bromobenzamide Preparation Products

• N-Benzyl 2-bromobenzamide (82082-50-6)

• 1. Fatty acid eutectic mixtures and derivatives from non-edible animal fat as phase change materials?
  Pau Gallart-Sirvent,Marc Martín,Gemma Villorbina,Mercè Balcells,Aran Solé,Luisa F. Cabeza,Ramon Canela-Garayoa RSC Adv., 2017,7, 24133-24139
• 2. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 3. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
  Amit Kumar Majhi,Subbarao Kanchi,V. Venkataraman,K. G. Ayappa,Prabal K. Maiti Soft Matter, 2015,11, 8632-8640
• 4. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
• 5. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzamides
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzamides

• 88229-24-7(2-Bromo-N-(prop-2-en-1-yl)benzamide)
• 8002-31-1(2-Bromo-N-ethylbenzamide)
• 64141-90-8(N-Isopropyl 2-bromobenzamide)
• 80031-02-3(N-Ethyl 2-bromobenzamide)
• 349403-39-0(N-Butyl 2-bromobenzamide)
• 124461-28-5(N-Benzyl-N-methyl 2-bromobenzamide)
• 76041-86-6(N,N-Diethyl-2-bromobenzamide)
• 8002-73-1(2-Bromo-N-ethylbenzamide)
• 8008-31-9(2-Bromo-N-ethylbenzamide)
• 61436-88-2(N-Methyl 2-bromobenzamide)