• 1. Application of organometallic catalysts for the synthesis of o-tolyl benzonitrile, a key starting material for sartans
  Anupam Jana,V. Ravichandiran,Sharada Prasanna Swain New J. Chem. 2021 45 17753
• 2. Special structural and dynamical interplay of cyano-based novel deep eutectic solvents
  Chen Fan,Yuwei Shan,Yaqi Yin,Xueli Cao New J. Chem. 2023 47 5356
• 3. Single-molecule photoredox catalysis
  Josef Haimerl,Indrajit Ghosh,Burkhard K?nig,Jan Vogelsang,John M. Lupton Chem. Sci. 2019 10 681
• 4. Generation and reaction of cyano-substituted aryllithium compounds using microreactors
  Aiichiro Nagaki,Heejin Kim,Hirotsugu Usutani,Chika Matsuo,Jun-ichi Yoshida Org. Biomol. Chem. 2010 8 1212
• 5. Low catalyst loading ligand-free palladium-catalyzed direct arylation of furans: an economically and environmentally attractive access to 5-arylfurans
  Jia Jia Dong,Julien Roger,Franc Po?gan,Henri Doucet Green Chem. 2009 11 1832

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzonitriles
• Solvents and Organic Chemicals Organic Compounds cyanides/Cyanides

Comprehensive Guide to 2-Bromobenzonitrile (CAS No. 2042-37-7): Properties, Applications, and Industry Insights

2-Bromobenzonitrile (CAS No. 2042-37-7) is a versatile organic compound widely utilized in pharmaceutical, agrochemical, and material science research. This brominated benzonitrile derivative features a cyano group (-CN) and a bromine atom at the ortho position of the benzene ring, making it a valuable intermediate for synthesizing complex molecules. Its molecular formula, C₇H₄BrN, and molecular weight of 182.02 g/mol contribute to its reactivity in cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings, which are pivotal in modern drug discovery.

In recent years, the demand for 2-Bromobenzonitrile has surged due to its role in developing high-performance liquid crystals and OLED materials, aligning with the global shift toward energy-efficient displays. Researchers also leverage its structural properties to design biologically active compounds, addressing trending topics like antiviral agents and cancer therapeutics. A 2023 study highlighted its potential as a precursor for kinase inhibitors, a hot topic in precision medicine.

From a synthetic perspective, 2-Bromobenzonitrile exhibits excellent solubility in organic solvents like dimethyl sulfoxide (DMSO) and dichloromethane (DCM), facilitating its use in multistep reactions. Its melting point (50–53°C) and boiling point (250°C) make it stable under various industrial conditions. Environmental and safety considerations are critical; thus, manufacturers emphasize green chemistry approaches, such as catalytic bromination, to minimize waste—a response to growing ESG (Environmental, Social, and Governance) concerns in the chemical sector.

The compound’s spectroscopic data, including NMR and IR spectra, are well-documented, aiding quality control in production. Analytical techniques like HPLC and GC-MS ensure purity levels exceeding 98%, meeting stringent regulatory standards for pharmaceutical intermediates. Suppliers often highlight these metrics to address customer queries about batch-to-batch consistency and supply chain transparency—key search terms in procurement discussions.

Emerging applications of 2-Bromobenzonitrile include its use in metal-organic frameworks (MOFs) for gas storage and catalysis, tapping into the booming clean energy sector. Additionally, its derivatives are explored in fluorescent probes for bioimaging, resonating with advancements in diagnostic technologies. These innovations align with frequent search queries like "benzonitrile derivatives in medicine" or "brominated aromatics in materials science," reflecting interdisciplinary interest.

To optimize SEO, this content integrates high-traffic keywords such as "buy 2-Bromobenzonitrile", "CAS 2042-37-7 suppliers", and "bromobenzonitrile synthesis", while maintaining technical depth. By contextualizing the compound within current scientific and industrial trends—such as sustainable chemistry and personalized medicine—this guide enhances readability and relevance for researchers, procurement specialists, and educators alike.

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