Production Method 1

81561-77-5

Reaction Conditions

1.1 Catalysts: Sodium bicarbonate Solvents: Toluene ;  24 h, rt

Reference

Facile and efficient acetylation of primary alcohols and phenols with acetic anhydride catalyzed by dried sodium bicarbonate

Lugemwa, Fulgentius Nelson; et al, Catalysts, 2013, 3(4), 954-965

Production Method 2

7598-28-9

81561-77-5

Reaction Conditions

1.1 Reagents: Cesium carbonate Catalysts: Di-μ-chlorobis[(1,2,3-η)-1-phenyl-2-propen-1-yl]dipalladium ,  Mor-DalPhos Solvents: 1,4-Dioxane ;  16 h, 90 °C

Reference

Palladium-Catalyzed Mono-α-arylation of Acetone with Aryl Halides and Tosylates

Hesp, Kevin D.; et al, Journal of the American Chemical Society, 2011, 133(14), 5194-5197

Production Method 3

61759-13-5

98-06-6

81561-77-5

Reaction Conditions

1.1 Catalysts: 9,10-Dimethoxyanthracene Solvents: Acetonitrile ;  20 - 25 h

Reference

Transition-metal-free photoredox intermolecular α-arylation of ketones

Pandey, Ganesh; et al, Organic Chemistry Frontiers, 2018, 5(17), 2610-2614

Production Method 4

108-22-5

769-92-6

81561-77-5

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Hydrochloric acid Solvents: Water ;  45 min, -5 °C; 15 min, -5 °C
1.2 Reagents: Hydrofluoric acid ,  Boric acid (H3BO3) ;  30 min, -5 °C; 2 h, 0 °C
1.3 Reagents: Sodium acetate Catalysts: Copper oxide (Cu2O) ;  30 min, 20 - 25 °C; 6 h, 20 - 25 °C

Reference

Synthesis and fungicidal activity of novel oxathiapiprolin derivatives

Ding, Chengrong; et al, Youji Huaxue, 2019, 39(7), 2062-2069

Production Method 5

18880-06-3

81561-77-5

Reaction Conditions

1.1 Catalysts: Acetic anhydride

Reference

Electrosynthesis of benzylic ketones

, France, , ,

Production Method 6

81561-77-5

Reaction Conditions

1.1 Reagents: Selenium dioxide Catalysts: Sulfuric acid Solvents: Dichloromethane ;  10 h, 10 °C
2.1 Catalysts: 9,10-Dimethoxyanthracene Solvents: Acetonitrile ;  20 - 25 h

Reference

Transition-metal-free photoredox intermolecular α-arylation of ketones

Pandey, Ganesh; et al, Organic Chemistry Frontiers, 2018, 5(17), 2610-2614

Production Method 7

3972-56-3

81561-77-5

Reaction Conditions

1.1 Reagents: Cesium carbonate Catalysts: Di-μ-chlorobis[(1,2,3-η)-1-phenyl-2-propen-1-yl]dipalladium ,  2-(Dicyclohexylphosphino)-3-methoxy-N-methyl-N-phenylbenzenamine ;  12 h, 90 °C

Reference

Zheda-Phos for General α-Monoarylation of Acetone with Aryl Chlorides

Li, Pengbin; et al, Advanced Synthesis & Catalysis, 2013, 355(7), 1255-1259

Production Method 8

81561-77-5

Reaction Conditions

1.1 Catalysts: Cobalt, bis[[2,3-butanedione di(oximato-κN)](1-)]chloro(pyridine)-, (OC-6-42)- ,  Acridinium, 10-methyl-9-(2,4,6-trimethylphenyl)-, perchlorate (1:1) Solvents: Acetonitrile ,  Water ;  24 h, rt

Reference

Anti-Markovnikov Oxidation of β-Alkyl Styrenes with H2O as the Terminal Oxidant

Zhang, Guoting; et al, Journal of the American Chemical Society, 2016, 138(37), 12037-12040

Production Method 9

59970-38-6

81561-77-5

Reaction Conditions

1.1 Reagents: Tripotassium phosphate Catalysts: Di-μ-chlorobis[(1,2,3-η)-1-phenyl-2-propen-1-yl]dipalladium ,  Mor-DalPhos Solvents: tert-Butanol ,  1,4-Dioxane ;  16 - 20 h, 90 °C

Reference

Addressing Challenges in Palladium-Catalyzed Cross-Couplings of Aryl Mesylates: Monoarylation of Ketones and Primary Alkyl Amines

Alsabeh, Pamela G.; et al, Angewandte Chemie, 2013, 52(28), 7242-7246

Production Method 10

58567-80-9

81561-77-5

Reaction Conditions

1.1 Catalysts: Dichloroacetic acid ,  (SP-4-1)-[Bis[μ-[[2,3-butanedione 2,3-di(oximato-κO)](2-)]]tetrafluorodiborato(2… ,  Acridinium, 3,6-bis(1,1-dimethylethyl)-9-(4-fluoro-2,6-dimethylphenyl)-10-phenyl… Solvents: Acetonitrile ,  Water ;  8 h, rt

Reference

Homobenzylic Oxygenation Enabled by Dual Organic Photoredox and Cobalt Catalysis

McManus, Joshua B.; et al, Journal of the American Chemical Society, 2020, 142(23), 10325-10330

Production Method 11

80-54-6

81561-77-5

Reaction Conditions

1.1 Reagents: Triethylamine ,  Oxygen Catalysts: Bis[5,5-dimethyl-1-(4-methyl-1-piperazinyl)-1,2,4-hexanetrionato-κO2,κO4]cobalt Solvents: Isopropanol ;  12 h, 60 °C

Reference

Cobalt-Catalyzed Aerobic Oxidative Cleavage of Alkyl Aldehydes: Synthesis of Ketones, Esters, Amides, and α-Ketoamides

Li, Tingting; et al, Chemistry - A European Journal, 2021, 27(38), 9737-9741

Production Method 12

35779-04-5

81561-77-5

Reaction Conditions

1.1 Reagents: Tripotassium phosphate Catalysts: Cuprous iodide Solvents: Dimethyl sulfoxide ;  heated

Reference

N-Heterocyclic Carbene-Catalyzed Aldol-Lactonization of Ketoacids via Dynamic Kinetic Resolution

Mondal, Santigopal; et al, ACS Catalysis, 2017, 7(6), 3995-3999

Production Method 13

1746-23-2

81561-77-5

18127-01-0

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Rhodium (α,ω-Bis(diphenylphosphino)poly(ethylene glycol) complexes and chloro c…) ,  Poly(oxy-1,2-ethanediyl), α-(diphenoxyphosphinyl)-ω-[(diphenoxyphosphinyl)oxy]- (rhodium complexes and chloro-rhodium complexes and dichloro-Ru and Pd …) Solvents: Toluene ,  Polyethylene glycol ;  5 MPa, rt → 80 °C; 6 h, 80 °C; 80 °C → rt

Reference

Approach for Catalyst-Product Separation Using Recyclable Liquid Phase Catalysis

Panda, Anil G.; et al, Industrial & Engineering Chemistry Research, 2010, 49(18), 8360-8364

Production Method 14

98-06-6

81561-77-5

58443-85-9

608489-87-8

Reaction Conditions

1.1 Catalysts: Manganese triacetate Solvents: Benzene ,  Pyridinium, 4-methyl-1-pentyl-, dodecahydro-1-carbadodecaborate(1-) ;  2 h

Reference

An effective system to synthesize arylacetones. Substrate-ionic liquid-ultrasonic irradiation

Zhu, Yinghuai; et al, Chemistry Letters, 2003, 32(8), 730-731

1-(4-tert-butylphenyl)propan-2-one Raw materials

• Isopropenyl acetate
• 3-(4-tert-butylphenyl)-2-methylpropanal
• Phosphonium, [[4-(1,1-dimethylethyl)phenyl]methyl]triphenyl-, chloride
• 1-tert-Butyl-4-iodobenzene
• 2-Propanone, 1-(phenylseleno)-
• 4-tert-Butylstyrene
• p-t-Butylaniline
• 4-t-butylphenyl methanesulfonate
• 1-Chloro-4-(1,1-dimethylethyl)benzene
• tert-Butylbenzene
• Benzene, 1-(1,1-dimethylethyl)-4-propyl-
• 4-tert-butylphenyl 4-methylbenzene-1-sulfonate

1-(4-tert-butylphenyl)propan-2-one Preparation Products

• 1-(4-tert-butylphenyl)propan-2-one (81561-77-5)
• 1-(2-tert-butylphenyl)propan-2-one (58443-85-9)
• 3-(4-tert-butylphenyl)propanal (18127-01-0)
• 1-(3-tert-butylphenyl)propan-2-one (608489-87-8)

• 1. Alternative donor substrates for inverting and retaining glycosyltransferases?
  Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367
• 2. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
• 3. Alumina coating on 5 V lithium cobalt fluorophosphate cathode material for lithium secondary batteries – synthesis and electrochemical properties?
  S. Amaresh,K. Karthikeyan,K. J. Kim,Y. S. Lee RSC Adv., 2014,4, 23107-23115
• 4. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 5. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylpropanes

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)