Production Method 1

5927-18-4

872-85-5

81124-49-4

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide Solvents: Tetrahydrofuran ;  30 min, 0 °C
1.2 4.5 h, 0 °C
1.3 Reagents: Ammonium chloride Solvents: Water

Reference

Development of tryptase inhibitors derived from thalidomide

Tetsuhashi, Masashi; et al, Bioorganic & Medicinal Chemistry, 2010, 18(14), 5323-5338

Production Method 2

1067-74-9

872-85-5

81124-49-4

Reaction Conditions

1.1 Reagents: Sodium bis(trimethylsilyl)amide Solvents: Dimethylformamide ,  Tetrahydrofuran ;  10 min, heated
1.2 Solvents: Dimethylformamide ;  1 h

Reference

Enhancing the Pharmacokinetic Properties of Botulinum Neurotoxin Serotype A Protease Inhibitors through Rational Design

Capek, Petr; et al, ACS Chemical Neuroscience, 2011, 2(6), 288-293

Production Method 3

2605-67-6

872-85-5

81124-49-4

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  12 h, reflux

Reference

Design, Synthesis, and Biological Evaluation of 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan Derivatives as Peripheral Selective μ Opioid Receptor Agents

Yuan, Yunyun; et al, Journal of Medicinal Chemistry, 2012, 55(22), 10118-10129

Production Method 4

2605-67-6

872-85-5

81124-49-4

Reaction Conditions

1.1 Solvents: Dichloromethane ;  rt; 5 h, reflux

Reference

Uranyl-Organic Coordination Compounds Incorporating Photoactive Vinylpyridine Moieties: Synthesis, Structural Characterization, and Light-Induced Fluorescence Attenuation

Wu, Si; et al, Inorganic Chemistry, 2018, 57(23), 14772-14785

Production Method 5

84228-93-3

81124-49-4

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  rt
1.2 Reagents: Ammonium chloride Solvents: Water ;  rt

Reference

Bifunctional iminophosphorane-catalyzed enantioselective nitroalkane addition to unactivated α,β-unsaturated esters

Rozsar, Daniel; et al, ChemRxiv, 2022, 1, 1-8

Production Method 6

141-82-2

872-85-5

81124-49-4

Reaction Conditions

1.1 Reagents: Piperidine Solvents: Pyridine ;  0.5 h, rt → 100 °C
2.1 Reagents: Sulfuric acid Solvents: Methanol ;  3 h, reflux; cooled
2.2 Reagents: Sodium bicarbonate Solvents: Water ;  neutralized

Reference

Structure-Guided, Single-Point Modifications in the Phosphinic Dipeptide Structure Yield Highly Potent and Selective Inhibitors of Neutral Aminopeptidases

Vassiliou, Stamatia; et al, Journal of Medicinal Chemistry, 2014, 57(19), 8140-8151

Production Method 7

2605-67-6

872-85-5

81124-49-4

Reaction Conditions

1.1 Solvents: Dichloromethane ;  5 h, reflux

Reference

A Supramolecular Protecting Group Strategy Introduced to the Organic Solid State: Enhanced Reactivity through Molecular Pedal Motion

Elacqua, Elizabeth; et al, Angewandte Chemie, 2012, 51(4), 1037-1041

Production Method 8

84228-93-3

81124-49-4

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Methanol ;  3 h, reflux; cooled
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  neutralized

Reference

Structure-Guided, Single-Point Modifications in the Phosphinic Dipeptide Structure Yield Highly Potent and Selective Inhibitors of Neutral Aminopeptidases

Vassiliou, Stamatia; et al, Journal of Medicinal Chemistry, 2014, 57(19), 8140-8151

Production Method 9

872-85-5

81124-49-4

Reaction Conditions

1.1 Reagents: Triphenylarsine ;  30 min, 80 °C; 80 °C → rt
1.2 Reagents: Diisopropylethylamine Solvents: Acetonitrile ;  15 min, rt

Reference

Synthesis of olefins via a Wittig reaction mediated by triphenylarsine

Li, Lun; et al, Tetrahedron Letters, 2017, 58(14), 1379-1381

Production Method 10

1120-87-2

81124-49-4

Reaction Conditions

1.1 Reagents: Sodium acetate Catalysts: Palladium nitrate ,  Bentolite H Solvents: N-Methyl-2-pyrrolidone ;  2 h, 150 °C

Reference

Efficient heterogeneous palladium-montmorillonite catalysts for Heck coupling of aryl bromides and chlorides

Molnar, Arpad; et al, Synlett, 2006, (18), 3130-3134

Production Method 11

84228-93-3

81124-49-4

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  rt
1.2 Reagents: Ammonium chloride Solvents: Water ;  30 min, rt

Reference

Bifunctional Iminophosphorane-Catalyzed Enantioselective Nitroalkane Addition to Unactivated α,β-Unsaturated Esters

Rozsar, Daniel ; et al, Angewandte Chemie, 2023, 62(21),

Production Method 12

15854-87-2

81124-49-4

Reaction Conditions

1.1 Reagents: Triethylamine Catalysts: 1802417-44-2 Solvents: Dimethylformamide ;  3 h, 65 °C

Reference

Trimetallic PEPPSI-Type Palladium N-Heterocyclic Carbene Complexes - Improved Catalyst Lifetime in the Mizoroki-Heck Coupling Reaction

Martinez-Olid, Francisco; et al, European Journal of Inorganic Chemistry, 2015, 2015(24), 4076-4087

Production Method 13

81124-49-4

Reaction Conditions

1.1 Catalysts: Silver ,  Gold Solvents: Methanol

Reference

Metal nanoparticle catalyzed cyclobutane cleavage reaction

Chen, Dengtai; et al, RSC Advances, 2015, 5(122), 100722-100724

Methyl 3-(pyridin-4-yl)acrylate Raw materials

• propanedioic acid
• 4-bromopyridine
• 4-Pyridineacrylic Acid
• 4-Iodopyridine
• Methyl diethylphosphonoacetate
• (Carbomethoxymethylene)triphenylphosphorane
• methyl 2-(dimethoxyphosphoryl)acetate
• pyridine-4-carbaldehyde

Methyl 3-(pyridin-4-yl)acrylate Preparation Products

• Methyl 3-(pyridin-4-yl)acrylate (81124-49-4)

• 1. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
  Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381
• 2. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 3. Alumina coating on 5 V lithium cobalt fluorophosphate cathode material for lithium secondary batteries – synthesis and electrochemical properties?
  S. Amaresh,K. Karthikeyan,K. J. Kim,Y. S. Lee RSC Adv., 2014,4, 23107-23115
• 4. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
• 5. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Fatty acid esters

• 7340-34-3(3-(4-pyridinyl)-2-Propenoic acid methyl ester)
• 24489-96-1(Ethyl (E)-3-(4-Pyridinyl)-2-propenoate)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)