• 1. Thermodynamically metastable chain and stable layered Co(NCS)2 coordination polymers: thermodynamic relations and magnetic properties
  Aleksej Jochim,Micha? Rams,Michael B?hme,Magdalena Ceglarska,Winfried Plass,Christian N?ther Dalton Trans. 2020 49 15310
• 2. Photo-induced magnetization and first-principles calculations of a two-dimensional cyanide-bridged Co–W bimetal assembly
  Y. Miyamoto,T. Nasu,N. Ozaki,Y. Umeta,H. Tokoro,K. Nakabayashi,S. Ohkoshi Dalton Trans. 2016 45 19249
• 3. Supramolecular nanotubes based on halogen bonding interactions: cooperativity and interaction with small guests
  Antonio Bauzá,Antonio Frontera Phys. Chem. Chem. Phys. 2017 19 12936
• 4. An unusual 3D-topology and dominant ferromagnetic couplings in two Cu(ii)–azide coordination polymers
  Morsy A. M. Abu-Youssef,Albert Escuer,Franz A. Mautner,Lars ?hrstr?m Dalton Trans. 2008 3553
• 5. Pyrazole chemistry. Part 4. Directed lithiation of 4-bromo-1-phenyl-sulphonylpyrazole: a convenient approach to vicinally disubstituted pyrazoles
  Gottfried Heinisch,Wolfgang Holzer,Sabine Pock J. Chem. Soc. Perkin Trans. 1 1990 1829

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives

Comprehensive Guide to 4-Bromopyridine (CAS No. 1120-87-2): Properties, Applications, and Industry Insights

4-Bromopyridine (CAS No. 1120-87-2) is a versatile heterocyclic organic compound widely used in pharmaceutical synthesis, agrochemical production, and material science. As a brominated pyridine derivative, it serves as a critical building block for cross-coupling reactions, particularly in Suzuki-Miyaura and Negishi couplings. Its molecular structure (C₅H₄BrN) features a bromine atom at the 4-position of the pyridine ring, enabling selective functionalization—a property highly valued in modern drug discovery and catalyst design.

Recent trends in green chemistry have spurred interest in optimizing synthetic routes for 4-bromopyridine. Researchers are exploring metal-free catalysis and microwave-assisted synthesis to improve yield while reducing environmental impact. Analytical techniques like HPLC purity testing and GC-MS characterization ensure compliance with stringent pharmaceutical-grade standards, addressing growing concerns about chemical traceability in supply chains.

The compound’s role in OLED materials has gained attention due to the booming flexible display market. When used as a precursor for electron-transport layers, 4-bromopyridine derivatives enhance device efficiency—a hot topic in materials science forums. Patent analyses reveal a 30% increase in applications related to organic semiconductors since 2020, reflecting its importance in next-gen electronics.

Safety profiles of halogenated pyridines remain a frequent search query among laboratory professionals. Proper handling requires nitrile gloves and fume hoods, though its classification falls outside hazardous categories under standard conditions. Storage recommendations emphasize argon-filled containers to prevent degradation, a detail often overlooked in chemical procurement workflows.

Market intelligence indicates rising demand from Asia-Pacific contract research organizations, driven by expanding generic drug manufacturing. Suppliers now offer custom synthesis services for isotopic-labeled variants (¹³C, ¹⁵N) to support metabolomics research—an emerging niche in life sciences. This aligns with increasing Google searches for "stable isotope pharmaceuticals" and "pyridine-based probes."

Innovative applications include its use as a ligand in transition metal catalysis for C-H activation reactions, a technique revolutionizing complex molecule assembly. Recent ACS journal publications highlight modified 4-bromopyridine complexes that achieve unprecedented enantioselectivity in asymmetric synthesis—addressing industry pain points in chiral drug production.

Environmental fate studies show 4-bromopyridine undergoes aerobic biodegradation within 28 days under OECD 301B guidelines, making it preferable to persistent halogenated compounds. This data responds to growing regulatory focus on sustainable chemical design, particularly in REACH compliance documentation.

For analytical chemists, HPLC method development for 4-bromopyridine quantification typically employs C18 reverse-phase columns with UV detection at 254 nm. Method optimization tips are among the top-viewed content in chromatography webinars, reflecting practical challenges in impurity profiling.

The compound’s crystallographic data (monoclinic space group P2₁/c) aids in computational chemistry modeling, with DFT calculations predicting its reactivity in SNAr reactions. Such computational approaches reduce experimental screening time—a key advantage in high-throughput discovery platforms.

Emerging flow chemistry protocols demonstrate continuous processing of 4-bromopyridine intermediates with 90% reduced solvent consumption. These advances align with circular economy principles now prioritized by EU chemical regulations, offering answers to popular queries about "solvent-free organic synthesis."

• 81045-39-8(5,8-Dibromoisoquinoline)
• 74129-11-6(4-Bromopyridine, hydrobromide)
• 58794-09-5(7-Bromoisoquinoline)
• 63927-22-0(8-Bromoisoquinoline)
• 163928-56-1(Pyridine, 3-bromo-,radical ion(1-) (9CI))
• 19524-06-2(4-Bromopyridine hydrochloride)
• 34784-05-9(6-Bromoisoquinoline)
• 66148-14-9(3-bromopyridine-d4)
• 56898-53-4(4-bromopyridine - borane (1:1))
• 626-55-1(3-Bromopyridine)