Production Method 1

953046-62-3

808740-52-5

Reaction Conditions

1.1 Reagents: Sodium bicarbonate ,  Iodine Catalysts: Tempo Solvents: Benzene ,  Water ;  9 h, rt

Reference

A rapid and efficient solvent-free microwave-assisted synthesis of pyrazolone derivatives containing substituted isoxazole ring

Zhang, Dawei; Zhang, Yumin; Zhao, Tianqi; Li, Jing; Hou, Yaya; et al, Tetrahedron, 2016, 72(22), 2979-2987

Production Method 2

953046-62-3

808740-52-5

Reaction Conditions

1.1 Reagents: Sodium bicarbonate ,  Iodine Catalysts: Tempo Solvents: Benzene ,  Water ;  9 h, rt

Reference

An efficient solvent-free synthesis of isoxazolyl-1,4-dihydropyridines on solid support SiO2 under microwave irradiation

Zhang, Dawei; Chen, Xiaodong; Guo, Xue; Zhang, Yumin; Hou, Yaya; et al, Monatshefte fuer Chemie, 2016, 147(9), 1605-1614

Production Method 3

953046-62-3

808740-52-5

Reaction Conditions

1.1 Reagents: Silica ,  Pyridinium chlorochromate Solvents: Dichloromethane ;  6 - 7 h, rt

Reference

Synthesis and biological evaluation of focused isoxazolylpiperidinylpiperazine library for dopamine D3 and D4 receptor antagonists

Landge, Kamalkishor P.; Oh, Ji Seon; Pae, Ae Nim; Park, Woo Kyu; Gong, Jae Yang; et al, Bulletin of the Korean Chemical Society, 2011, 32(7), 2449-2452

Production Method 4

446-52-6

808740-52-5

Reaction Conditions

1.1 Reagents: Sodium carbonate ,  Hydroxyamine hydrochloride Solvents: Ethanol ,  Water ;  1 h, 60 °C
1.2 Reagents: Chlorosuccinimide Catalysts: Pyridine Solvents: Tetrahydrofuran ;  0.5 h, 60 °C
1.3 Reagents: Triethylamine ;  50 °C; 2 h, rt
1.4 Reagents: Silica ,  Pyridinium chlorochromate Solvents: Dichloromethane ;  5 h

Reference

Synthesis and biological evaluation of novel T-type Ca2+ channel blockers

Jung, Hee Kyung; Doddareddy, Munikumar Reddy; Cha, Joo Hwan; Rhim, Hyewhon; Cho, Yong Seo; et al, Bioorganic & Medicinal Chemistry, 2004, 12(15), 3965-3970

3-(2-Fluorophenyl)isoxazole-5-carbaldehyde Raw materials

• 2-Fluorobenzaldehyde
• (3-(2-Fluorophenyl)isoxazol-5-yl)methanol

3-(2-Fluorophenyl)isoxazole-5-carbaldehyde Preparation Products

• 3-(2-Fluorophenyl)isoxazole-5-carbaldehyde (808740-52-5)

• 1. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
• 2. An anti-leakage liquid metal thermal interface material
  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
• 3. An atlas of endohedral Sc2S cluster fullerenes?
  Li-Hua Gan,Rui Wu,Jian-Lei Tian,Patrick W. Fowler Phys. Chem. Chem. Phys., 2017,19, 419-425
• 4. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
• 5. An investigation of the electrochemical delithiation process of carbon coated α-Fe2O3nanoparticles
  Adrian Brandt,Florian Winter,Sebastian Klamor,Frank Berkemeier,Jatinkumar Rana,Rainer P?ttgen,Andrea Balducci J. Mater. Chem. A, 2013,1, 11229-11236

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Fluorobenzenes

• 491875-99-1(3-(4-fluorophenyl)-5-methyl-1,2-oxazole)
• 885273-52-9(3-(3-Fluorophenyl)isoxazole-5-carbaldehyde)
• 885273-54-1(3-(3-methylphenyl)-1,2-oxazole-5-carbaldehyde)
• 1152531-95-7(3-(2,6-difluorophenyl)-1,2-oxazole-5-carboxylic acid)
• 251912-65-9(3-(4-fluorophenyl)-1,2-oxazole-5-carbaldehyde)
• 901926-86-1(3-(2,5-difluorophenyl)-1,2-oxazole-5-carboxylic acid)
• 251912-67-1(3-(4-methylphenyl)-1,2-oxazole-5-carbaldehyde)
• 72418-40-7(3-phenyl-1,2-oxazole-5-carbaldehyde)
• 885273-60-9(3-(3,5-dimethylphenyl)-1,2-oxazole-5-carbaldehyde)
• 842973-74-4(3-(2-Fluorophenyl)isoxazole-5-carboxylic acid)