Production Method 1

6900-35-2

61214-14-0

80750-05-6

Reaction Conditions

1.1 Reagents: 4-Methoxyphenol ,  Potassium iodide Catalysts: 4-(Dimethylamino)pyridine Solvents: Dimethylformamide

Reference

Synthesis of organofunctional silanes with sterically hindered substituents at silicon atoms

Gulinski, Jacek; et al, Applied Organometallic Chemistry, 2001, 15(8), 649-657

Production Method 2

2530-85-0

80750-05-6

Reaction Conditions

1.1 Catalysts: p-Toluenesulfonic acid Solvents: Isopropanol ;  5 h, 100 °C

Reference

Coating of silica particles by fluorinated diblock copolymers and use of the resultant silica for superamphiphobic surfaces

Grozea, Claudia M.; et al, Polymer, 2015, 64, 153-162

Production Method 3

2530-85-0

80750-05-6

Reaction Conditions

1.1 Catalysts: p-Toluenesulfonic acid ;  5 h, 100 °C

Reference

Synthesis of poly(dimethylsiloxane)-block-poly[3-(triisopropyloxysilyl) propyl methacrylate] and its use in the facile coating of hydrophilically patterned superhydrophobic fabrics

Rabnawaz, Muhammad; et al, RSC Advances, 2015, 5(49), 39505-39511

Production Method 4

2530-85-0

80750-05-6

Reaction Conditions

1.1 Catalysts: p-Toluenesulfonic acid ;  5 h, 100 °C; 30 min, 100 °C

Reference

Clear Antismudge Unimolecular Coatings of Diblock Copolymers on Glass Plates

Macoretta, Danielle; et al, ACS Applied Materials & Interfaces, 2014, 6(23), 21435-21445

Production Method 5

2530-87-2

80750-05-6

Reaction Conditions

1.1 Catalysts: Titanium tetrabutoxide Solvents: Isopropanol
2.1 Reagents: 4-Methoxyphenol ,  Potassium iodide Catalysts: 4-(Dimethylamino)pyridine Solvents: Dimethylformamide

Reference

Synthesis of organofunctional silanes with sterically hindered substituents at silicon atoms

Gulinski, Jacek; et al, Applied Organometallic Chemistry, 2001, 15(8), 649-657

Production Method 6

2550-06-3

80750-05-6

Reaction Conditions

1.1 Solvents: Isopropanol
2.1 Reagents: 4-Methoxyphenol ,  Potassium iodide Catalysts: 4-(Dimethylamino)pyridine Solvents: Dimethylformamide

Reference

Synthesis of organofunctional silanes with sterically hindered substituents at silicon atoms

Gulinski, Jacek; et al, Applied Organometallic Chemistry, 2001, 15(8), 649-657

2-Propenoic acid,2-methyl-, 3-[tris(1-methylethoxy)silyl]propyl ester Raw materials

• (3-Chloropropyl)trimethoxysilane
• Trichloro(3-chloropropyl)silane
• 2-Propenoic acid,2-methyl-, potassium salt (1:1)
• Silane coupler (G-570)
• Silane,(3-chloropropyl)tris(1-methylethoxy)-

2-Propenoic acid,2-methyl-, 3-[tris(1-methylethoxy)silyl]propyl ester Preparation Products

• 2-Propenoic acid,2-methyl-, 3-[tris(1-methylethoxy)silyl]propyl ester (80750-05-6)

• 1. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
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• 4. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
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• 5. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119

Professional Introduction to 2-Propenoic acid, 2-methyl-, 3-[tris(1-methylethoxy)silyl]propyl ester (CAS No. 80750-05-6)

2-Propenoic acid, 2-methyl-, 3-[tris(1-methylethoxy)silyl]propyl ester, identified by the Chemical Abstracts Service Number (CAS No.) 80750-05-6, is a specialized organosilicon compound that has garnered significant attention in the field of organic synthesis and pharmaceutical chemistry. This compound belongs to the class of silylated esters, which are widely utilized as protecting groups and intermediates in the synthesis of complex molecules, particularly in the development of novel therapeutic agents. The unique structural features of this compound, including its tris(1-methylethoxy)silylpropyl ester moiety, make it a valuable tool for chemists working on the synthesis of heterocyclic compounds and biologically active molecules.

The molecular structure of 2-Propenoic acid, 2-methyl-, 3-[tris(1-methylethoxy)silyl]propyl ester consists of a methyl acrylic acid backbone modified with a highly substituted silicon group. The presence of three 1-methylethoxy groups attached to the silicon atom enhances its stability and reactivity, making it an effective protecting group in various synthetic transformations. This feature is particularly useful in multi-step syntheses where selective protection and deprotection steps are required to achieve high yields and purity.

In recent years, there has been a surge in research focused on the development of new synthetic methodologies for complex pharmaceutical intermediates. The use of silylated esters, such as 3-[tris(1-methylethoxy)silyl]propyl ester, has become increasingly prevalent due to their ability to facilitate regioselective reactions and protect sensitive functional groups from unwanted side reactions. For instance, studies have demonstrated its utility in the synthesis of nonsteroidal anti-inflammatory drugs (NSAIDs) and other therapeutic agents where precise control over reaction pathways is crucial.

One of the most compelling applications of this compound is in the field of proteomics and mass spectrometry-based protein analysis. Silylated derivatives are often employed to enhance the ionization efficiency of peptides and proteins during mass spectrometry experiments. The tris(1-methylethoxy)silylpropyl ester group provides excellent stability under high temperatures and acidic conditions, making it an ideal candidate for derivatization purposes. Recent advancements in this area have shown that compounds like 2-Propenoic acid, 2-methyl-, 3-[tris(1-methylethoxy)silyl]propyl ester can significantly improve the sensitivity and resolution of protein identification techniques, thereby accelerating the discovery of novel biomarkers and therapeutic targets.

The pharmaceutical industry has also explored the potential of this compound as a precursor for more complex drug candidates. By leveraging its reactivity, researchers have been able to construct intricate molecular frameworks that exhibit desirable pharmacological properties. For example, modifications involving the methyl acrylic acid moiety have been investigated for their potential role in modulating enzyme activity and receptor binding affinity. These efforts align with broader trends in drug discovery where structural diversity is being harnessed to overcome challenges associated with drug resistance and side effects.

Furthermore, the environmental impact of synthetic methodologies has prompted researchers to develop greener alternatives. The use of silicon-based protecting groups offers several advantages over traditional methods, including reduced waste generation and improved reaction efficiency. In line with this trend, studies have been conducted to assess the biodegradability and toxicity profile of compounds like 3-[tris(1-methylethoxy)silyl]propyl ester, ensuring that their application aligns with sustainable chemistry principles.

The role of computational chemistry in optimizing synthetic routes cannot be overstated. Modern computational tools have enabled researchers to predict the behavior of complex molecules with unprecedented accuracy. By simulating reaction mechanisms involving 2-Propenoic acid, 2-methyl-, 3-[tris(1-methylethoxy)silyl]propyl ester, scientists can identify optimal conditions for synthesis, minimizing trial-and-error experimentation and reducing costs associated with material consumption.

In conclusion, 2-Propenoic acid, 2-methyl-, 3-[tris(1-methylethoxy)silyl]propyl ester (CAS No. 80750-05-6) represents a significant advancement in synthetic chemistry with far-reaching implications for pharmaceutical research and development. Its unique structural features make it an indispensable tool for constructing complex molecular architectures, while its stability under harsh conditions ensures reliable performance in various applications. As research continues to evolve, it is likely that this compound will play an even greater role in shaping the future of drug discovery and molecular biology.

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