Cas no 799842-07-2 (5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-methyl(methylsulfonyl)aminopyrimidine)

5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-methyl(methylsulfonyl)aminopyrimidine is a brominated pyrimidine derivative with significant utility in pharmaceutical and agrochemical synthesis. Its key structural features—a bromomethyl group, fluorophenyl substituent, and isopropyl moiety—enhance reactivity and selectivity in cross-coupling and substitution reactions. The methylsulfonylamino group further contributes to its versatility as an intermediate in medicinal chemistry, particularly for developing kinase inhibitors or antimicrobial agents. The compound’s well-defined reactivity profile and stability under controlled conditions make it a valuable building block for constructing complex heterocyclic frameworks. Its high purity and consistent performance ensure reliability in research and industrial applications.
5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-methyl(methylsulfonyl)aminopyrimidine structure
799842-07-2 structure
Product Name:5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-methyl(methylsulfonyl)aminopyrimidine
CAS No:799842-07-2
MF:C16H19BrFN3O2S
MW:416.308365106583
MDL:MFCD08694308
CID:68860
PubChem ID:16638881
Update Time:2025-06-07

5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-methyl(methylsulfonyl)aminopyrimidine Chemical and Physical Properties

Names and Identifiers

    • N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide
    • N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl]-N-methylmethanesulfonamide
    • 5-(BROMOMETHYL)-4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[METHYL(METHYLSULFONYL)AMINO]PYRIMIDINE
    • Methanesulfonamide, N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-
    • N-[5-(bromomethyl)-4-(4-fluorophenyl)-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide
    • N-[5-bromomethyl-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide
    • N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropropyl-pyrimidine-2-yl]-N-methylmethane sulfonamide
    • Rosuvastatin Z-8
    • PHEVHIWIKJRWDB-UHFFFAOYSA-N
    • BCP10918
    • AX8216655
    • W8519
    • ST24025671
    • A24852
    • 842B072
    • Methanesulfonamide,N-[5-(bromometh
    • 799842-07-2
    • N-[5-(BROMOMETHYL)-4-(4-FLUOROPHENYL)-6-ISOPROPYLPYRIMIDIN-2-YL]-N-METHYLMETHANESULFONAMIDE
    • :N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide
    • CS-0165318
    • N-(5-(bromomethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide? (Rosuvastatin Impurity pound(c)
    • N-(5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide
    • DS-15541
    • MFCD08694308
    • C16H19BrFN3O2S
    • AMY3277
    • N-[5-(Bromomethyl)-4-(4-fluorophenyl)-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide
    • N-[5-bromomethyl-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide;5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine;N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethane sulfonamide
    • N-[5-bromomethyl-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-2-yl]-N-methyl-methanesulfonamide
    • AC-3406
    • FT-0653120
    • SCHEMBL246597
    • N-[5-Bromomethyl-4-(4-fluorophenyl)-6-isopropylpyrimidine-2-yl]-N-methylmethanesulfonamide
    • N-(4-(4-fluorophenyl)-5-(bromomethyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide
    • DTXSID60586274
    • AKOS000280338
    • N-[5-(Bromomethyl)-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methylmethanesulfonamide (ACI)
    • N-(4-(4-Fluorophenyl)-5-(bromomethyl)-6-isopropyl-pyrimidin-2-yl)-N-methyl-methanesulfonamide
    • DB-037962
    • A11608
    • 5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-methyl(methylsulfonyl)aminopyrimidine
    • MDL： MFCD08694308
    • Inchi： 1S/C16H19BrFN3O2S/c1-10(2)14-13(9-17)15(11-5-7-12(18)8-6-11)20-16(19-14)21(3)24(4,22)23/h5-8,10H,9H2,1-4H3
    • InChI Key： PHEVHIWIKJRWDB-UHFFFAOYSA-N
    • SMILES： O=S(C)(N(C)C1N=C(C(C)C)C(CBr)=C(C2C=CC(F)=CC=2)N=1)=O

Computed Properties

  • Exact Mass: 415.03700
  • Monoisotopic Mass: 415.03654g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 6
  • Heavy Atom Count: 24
  • Rotatable Bond Count: 5
  • Complexity: 506
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 71.5
  • XLogP3: 3.2

Experimental Properties

  • Color/Form: Not available
  • Density: 1.466
  • Melting Point: Not available
  • Boiling Point: 531.178°C at 760 mmHg
  • Flash Point: Not available
  • Refractive Index: 1.586
  • PSA: 71.54000
  • LogP: 4.77760
  • Vapor Pressure: Not available

5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-methyl(methylsulfonyl)aminopyrimidine Security Information

5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-methyl(methylsulfonyl)aminopyrimidine Pricemore >>

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5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-methyl(methylsulfonyl)aminopyrimidine Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Diisobutylaluminum hydride Solvents: Toluene ;  -10 °C; 0.5 h, -10 °C
1.2 Reagents: Hydrochloric acid Solvents: Water
2.1 Reagents: Phosphorus tribromide Solvents: Dichloromethane ;  0 °C; 0.5 h, 0 °C
2.2 Reagents: Sodium bicarbonate Solvents: Water
Reference
An efficient, cyanide free total synthesis of rosuvastatin calcium
Vempala, Naresh; et al, Tetrahedron, 2022, 111,

Production Method 2

Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Ethyl acetate ;  rt → 70 °C; 3 h, 70 °C
2.1 Reagents: Potassium carbonate Solvents: Toluene ;  rt → 120 °C; 24 h, 120 °C; 120 °C → rt
2.2 Reagents: Water ;  rt
3.1 Reagents: Diisobutylaluminum hydride Solvents: Toluene ;  -10 °C; 0.5 h, -10 °C
3.2 Reagents: Hydrochloric acid Solvents: Water
4.1 Reagents: Phosphorus tribromide Solvents: Dichloromethane ;  0 °C; 0.5 h, 0 °C
4.2 Reagents: Sodium bicarbonate Solvents: Water
Reference
An efficient, cyanide free total synthesis of rosuvastatin calcium
Vempala, Naresh; et al, Tetrahedron, 2022, 111,

Production Method 3

Reaction Conditions
1.1 Reagents: Phosphorus tribromide Solvents: Acetonitrile ,  Toluene ;  rt; 1 h, rt
1.2 Reagents: Sodium chloride Solvents: Water ;  rt
Reference
Palladium-Catalyzed Stereoselective Cyclization of in Situ Formed Allenyl Hemiacetals: Synthesis of Rosuvastatin and Pitavastatin
Spreider, Pierre A.; et al, Organic Letters, 2018, 20(11), 3286-3290

Production Method 4

Reaction Conditions
1.1 Reagents: Sodium borohydride Solvents: Methanol ,  Tetrahydrofuran ;  0 °C; 30 min, 0 °C; 30 min, rt
2.1 Reagents: Phosphorus tribromide Solvents: Acetonitrile ,  Toluene ;  rt; 1 h, rt
2.2 Reagents: Sodium chloride Solvents: Water ;  rt
Reference
Palladium-Catalyzed Stereoselective Cyclization of in Situ Formed Allenyl Hemiacetals: Synthesis of Rosuvastatin and Pitavastatin
Spreider, Pierre A.; et al, Organic Letters, 2018, 20(11), 3286-3290

Production Method 5

Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Toluene ;  rt → 120 °C; 24 h, 120 °C; 120 °C → rt
1.2 Reagents: Water ;  rt
2.1 Reagents: Diisobutylaluminum hydride Solvents: Toluene ;  -10 °C; 0.5 h, -10 °C
2.2 Reagents: Hydrochloric acid Solvents: Water
3.1 Reagents: Phosphorus tribromide Solvents: Dichloromethane ;  0 °C; 0.5 h, 0 °C
3.2 Reagents: Sodium bicarbonate Solvents: Water
Reference
An efficient, cyanide free total synthesis of rosuvastatin calcium
Vempala, Naresh; et al, Tetrahedron, 2022, 111,

5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-methyl(methylsulfonyl)aminopyrimidine Raw materials

5-(Bromomethyl)-4-(4-fluorophenyl)-6-isopropyl-2-methyl(methylsulfonyl)aminopyrimidine Preparation Products

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Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:799842-07-2)5-(溴甲基)-4-(4-氟苯基)-6-異丙基-2-[甲基(甲磺酰)氨基]嘧啶
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Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:47
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Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:799842-07-2)5-(溴甲基)-4-(4-氟苯基)-6-異丙基-2-[甲基(甲磺酰)氨基]嘧啶
LE8437372
Purity:99%
Quantity:25KG,200KG,1000KG
Price ($):Inquiry
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