Production Method 1

1207460-34-1

953776-62-0

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  10 min, -5 °C
1.2 Solvents: Dichloromethane ;  -5 °C; 8 h, -5 °C

Reference

Concise and highly efficient approach to three key pyrimidine precursors for rosuvastatin synthesis

Sterk, Damjan; Casar, Zdenko; Jukic, Marko; Kosmrlj, Janez, Tetrahedron, 2012, 68(9), 2155-2160

Production Method 2

1207460-34-1

953776-62-0

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  rt → 0 °C
1.2 0 °C; 0 °C → rt; 2 h, rt

Reference

Method for preparing rosuvastatin precursor

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Production Method 3

853295-26-8

14477-72-6

953776-62-0

Reaction Conditions

1.1 Reagents: Sodium bis(trimethylsilyl)amide Solvents: Toluene ;  20 °C
1.2 Reagents: L-erythro-Hexuronic acid, 3,5-dideoxy-4-O-[(1,1-dimethylethyl)dimethylsilyl]-, δ… ;  5 min, 20 °C

Reference

Lactone Pathway to Statins Utilizing the Wittig Reaction. The Synthesis of Rosuvastatin

Casar, Zdenko; Steinbucher, Miha; Kosmrlj, Janez, Journal of Organic Chemistry, 2010, 75(19), 6681-6684

Production Method 4

1207460-34-1

953776-62-0

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Dichloromethane ;  10 min, -5 °C
1.2 Solvents: Dichloromethane ;  -5 °C; 10 h, -5 °C

Reference

Preparation of bromomethyl, hydroxymethyl or formyl-containing rosuvastatin calcium intermediate

, China, , ,

Production Method 5

1207460-34-1

953776-62-0

Reaction Conditions

1.1 Solvents: Dichloromethane ;  rt → -5 °C
1.2 Reagents: Triethylamine ;  10 min, -5 °C
1.3 Solvents: Dichloromethane ;  -5 °C; 8 h, -5 °C
1.4 Solvents: Dichloromethane ;  -5 °C → rt

Reference

Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof

, World Intellectual Property Organization, , ,

Production Method 6

953776-62-0

Reaction Conditions

Reference

Key intermediates for the synthesis of rosuvastatin or pharmaceutically acceptable salts thereof

, United States, , ,

Production Method 7

953776-62-0

Reaction Conditions

Reference

Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof

, United States, , ,

Production Method 8

885477-83-8

953776-62-0

934263-64-6

Reaction Conditions

1.1 Reagents: Sodium bis(trimethylsilyl)amide Solvents: Tetrahydrofuran ;  45 min, -42 °C; -42 °C → -82 °C
1.2 Solvents: Tetrahydrofuran ;  30 min, -82 °C; -82 °C → -53 °C; 6 h, -58 - -53 °C; -53 °C → rt
1.3 Reagents: Ammonium chloride Solvents: Water ;  10 min, 10 °C

Reference

Process for preparation of key intermediates for synthesis of rosuvastatin

, World Intellectual Property Organization, , ,

N-4-(4-Fluorophenyl)-5-methyl-6-(1-methylethyl)-2-pyrimidinyl-N-methylmethanesulfonamide Raw materials

• 4-(4-fluorophenyl)-6-isopropyl-N,5-dimethylpyrimidin-2-amine
• Tributyl[[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]methyl]phosphonium
• Rosuvastatin Triphenylphosphonium Bromide
• Acetic acid,2,2,2-trifluoro-, ion(1-)

N-4-(4-Fluorophenyl)-5-methyl-6-(1-methylethyl)-2-pyrimidinyl-N-methylmethanesulfonamide Preparation Products

• N-[5-[(1E)-2-[(2S,4R)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]tetrahydro-6-oxo-2H-pyran-2-yl]ethenyl]-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methylmethanesulfonamide (934263-64-6)
• N-4-(4-Fluorophenyl)-5-methyl-6-(1-methylethyl)-2-pyrimidinyl-N-methylmethanesulfonamide (953776-62-0)

• 1. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090
• 2. Fatty acid eutectic mixtures and derivatives from non-edible animal fat as phase change materials?
  Pau Gallart-Sirvent,Marc Martín,Gemma Villorbina,Mercè Balcells,Aran Solé,Luisa F. Cabeza,Ramon Canela-Garayoa RSC Adv., 2017,7, 24133-24139
• 3. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
• 4. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 5. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
  Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168

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