Production Method 1

144-98-9

79617-27-9

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Methanol ;  20 °C; 0 °C

Reference

A Novel N-Substituted Valine Derivative with Unique Peroxisome Proliferator-Activated Receptor γ Binding Properties and Biological Activities

Peiretti, Franck ; Montanari, Roberta; Capelli, Davide; Bonardo, Bernadette; Colson, Cecilia; et al, Journal of Medicinal Chemistry, 2020, 63(21), 13124-13139

Production Method 2

28954-12-3

79617-27-9

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  0 °C
1.2 0 °C; 3 h, 40 °C

Reference

Synthetic Access to 3-Substituted Pyroglutamic Acids from Tetramate Derivatives of Serine, Threonine, allo-Threonine, and Cysteine

Bagum, Halima; Christensen, Kirsten E.; Genov, Miroslav; Pretsch, Alexander; Pretsch, Dagmar; et al, Journal of Organic Chemistry, 2019, 84(16), 10257-10279

Production Method 3

28954-12-3

79617-27-9

Reaction Conditions

1.1 Reagents: Acetyl chloride ;  0 °C → reflux

Reference

Alleviation of asthma-related symptoms by a derivative of L-allo threonine

Heo, Jin-Chul; Lee, Sang-Han, International Journal of Molecular Medicine, 2013, 31(4), 881-887

Production Method 4

28954-12-3

79617-27-9

Reaction Conditions

1.1 Reagents: Acetyl chloride ;  15 min, 0 °C
1.2 12 h, 50 °C

Reference

Synthesis of β-silyl-α-amino acid derivatives by Cu-catalyzed regio- and enantioselective silylamination of α,β-unsaturated esters

Kobayashi, Toshimichi; Nishino, Soshi; Miura, Masahiro ; Hirano, Koji, Organic Letters, 2022, 24(6), 1418-1422

Production Method 5

28954-12-3

79617-27-9

Reaction Conditions

1.1 Reagents: Thionyl chloride

Reference

Serine and Threonine β-Lactones: A New Class of Hepatitis A Virus 3C Cysteine Proteinase Inhibitors

Lall, Manjinder S.; Ramtohul, Yeeman K.; James, Michael N. G.; Vederas, John C., Journal of Organic Chemistry, 2002, 67(5), 1536-1547

Production Method 6

82659-84-5

79617-27-9

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  rt → reflux; 5 h, reflux; reflux → 0 °C
1.2 Reagents: Thionyl chloride Solvents: Methanol ;  0 °C; 1 h, 0 °C → reflux; reflux; reflux; rt
1.3 Reagents: Hydrochloric acid Solvents: Methanol ;  rt → reflux; 1 h, reflux; reflux → rt

Reference

Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold

Liang, Xiaofei; Lee, Chul-Jin; Chen, Xin; Chung, Hak Suk; Zeng, Daina; et al, Bioorganic & Medicinal Chemistry, 2011, 19(2), 852-860

Production Method 7

28954-12-3

79617-27-9

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  0 °C; 0 °C → 40 °C; 3 h, 40 °C

Reference

Synthetic access to 3,4-disubstituted pyroglutamates from tetramate derivatives from serine, allo-threonine and cysteine

Bagum, Halima; Christensen, Kirsten E.; Genov, Miroslav; Pretsch, Alexander; Pretsch, Dagmar; et al, Tetrahedron, 2019, 75(40),

Production Method 8

2055961-48-1

79617-27-9

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Methanol ;  0 °C; 30 min, 0 °C
1.2 0 °C; 0 °C → 80 °C; 2 h, 80 °C

Reference

Synthesis of sialic acid derivatives based on chiral substrate-controlled stereoselective aldol reactions using pyruvic acid oxabicyclo[2.2.2]octyl orthoester

Norimura, Yusuke; Yamamoto, Daisuke; Makino, Kazuishi, Organic & Biomolecular Chemistry, 2017, 15(3), 640-648

Production Method 9

28954-12-3

79617-27-9

Reaction Conditions

1.1 Reagents: Acetyl chloride Solvents: Methanol ;  0 °C; 0 °C → reflux; 1 h, reflux

Reference

A derivative of L-allo threonine alleviates 2,4-dinitrofluorobenzene-induced atopic dermatitis indications

Heo, Jin-Chul; Son, Hyeong-U.; Kim, Solomon L.; Lee, Sang-Han, Bioscience, 2012, 76(11), 2021-2025

Production Method 10

28954-12-3

79617-27-9

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Methanol

Reference

The synthesis of novel chiral ferrocenyl aziridino alcohol ligands with two stereogenic carbons and structural characteristics

Wang, Qian; Hou, Xuehui; Wang, Mincan, Advanced Materials Research (Durnten-Zurich, 2012, 518, 518-523

L-allo-Threonine methyl ester hydrochloride Raw materials

• methyl (4s,5s)-dihydro-5-methyl-2-phenyl-4-oxazolecarboxylate
• (2S,3S)-2-amino-3-hydroxybutanoic acid hydrochloride
• L-allo-Threonine
• DL-allo-Threonine

L-allo-Threonine methyl ester hydrochloride Preparation Products

• L-allo-Threonine methyl ester hydrochloride (79617-27-9)

• 1. Achieving high-efficiency purely organic room-temperature phosphorescence materials by boronic ester substitution of phenoxathiine?
  Mengke Li,Xinyi Cai,Zhenyang Qiao,Wentao Xie,Liangying Wang,Nan Zheng,Shi-Jian Su Chem. Commun., 2019,55, 7215-7218
• 2. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 3. An ion-gating multinanochannel system based on a copper-responsive self-cleaving DNAzyme?
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• 5. An approach for correlating the structural and electrical properties of Zr4+-modified SrBi4Ti4O15/SBT ceramic
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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

• 39994-75-7(H-Thr-OMe.HCl)
• 62062-63-9(L-Threonine, butyl ester, hydrochloride)
• 33368-36-4(Threonine, ethyl ester,hydrochloride (1:1))
• 60538-18-3(methyl (2R,3R)-2-amino-3-hydroxy-butanoate;hydrochloride)
• 62076-66-8(Dl-threonine methyl ester hydrochloride)
• 62365-20-2(D-Threonine, ethyl ester, hydrochloride)
• 82679-55-8(methyl (2R,3S)-2-amino-3-hydroxybutanoate)
• 3373-59-9((2S,3R)-methyl 2-amino-3-hydroxybutanoate)
• 39994-70-2(Ethyl (2R,3R)-2-amino-3-hydroxybutanoate;hydrochloride)
• 60538-15-0(D-Threonine Methyl Ester Hydrochloride)