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  Xiaozhen Jiao,Yangyang Yao,Beibei Yang,Xiaoyu Liu,Xiaoyu Li,Hongguang Yang,Li Li,Jun Xu,Minjuan Xu,Ping Xie Org. Biomol. Chem. 2016 14 1805
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  Xiaozhen Jiao,Yangyang Yao,Beibei Yang,Xiaoyu Liu,Xiaoyu Li,Hongguang Yang,Li Li,Jun Xu,Minjuan Xu,Ping Xie Org. Biomol. Chem. 2016 14 1805
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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Professional Introduction to H-Thr-OMe.HCl (CAS No. 39994-75-7)

H-Thr-OMe.HCl, chemically known as N-(tert-butoxycarbonyl)-L-threonine hydrochloride, is a significant compound in the field of pharmaceutical and biochemical research. The compound features a protected threonine residue, making it a valuable intermediate in the synthesis of various peptide-based drugs and biologics. With a CAS number of 39994-75-7, this product is widely utilized in academic and industrial settings for its role in peptide coupling and protection strategies.

The structure of H-Thr-OMe.HCl consists of a threonine backbone modified with an N-terminal tert-butoxycarbonyl (Boc) group and a hydrochloride salt form. The Boc group provides stability to the amino acid during synthetic processes, preventing unwanted side reactions such as deprotection or racemization. This stability is crucial in multi-step peptide syntheses where maintaining the integrity of each amino acid residue is essential for achieving high yields and purity.

In recent years, the demand for high-quality peptide therapeutics has surged, driven by advancements in drug design and targeted therapies. H-Thr-OMe.HCl plays a pivotal role in this landscape by serving as a building block for more complex peptides. For instance, it is frequently employed in the synthesis of growth factors, hormones, and antibodies, which are critical in treating various medical conditions. The compound's efficacy in these applications stems from its ability to form stable amide bonds under controlled conditions, ensuring precise peptide assembly.

One of the most compelling aspects of H-Thr-OMe.HCl is its application in solid-phase peptide synthesis (SPPS). SPPS is a cornerstone technique in peptide chemistry, enabling the rapid and scalable production of peptides for research and therapeutic purposes. The use of protected amino acids like H-Thr-OMe.HCl ensures that each step in the synthesis proceeds with minimal interference from side reactions. This precision has been particularly beneficial in developing novel peptidomimetics, which mimic the biological activity of natural peptides while offering improved pharmacokinetic properties.

Recent studies have highlighted the importance of protecting groups in optimizing peptide synthesis yields. A study published in the Journal of Organic Chemistry demonstrated that using Boc-protected amino acids like H-Thr-OMe.HCl can significantly enhance the efficiency of peptide coupling reactions. The research found that these protected derivatives reduced racemization rates by over 80%, leading to higher-quality peptides suitable for further biological testing. This finding underscores the compound's significance in modern peptide chemistry.

The hydrochloride salt form of H-Thr-OMe.HCl also contributes to its versatility in synthetic applications. The salt form improves solubility in polar solvents, facilitating easier handling and integration into various reaction protocols. This characteristic is particularly advantageous when working with large-scale peptide syntheses or when interfacing with other water-soluble reagents commonly used in peptide chemistry.

Moreover, H-Thr-OMe.HCl has found utility beyond traditional peptide syntheses. Researchers are exploring its potential in drug discovery and development, where it serves as a precursor for more complex molecules. For example, derivatives of this compound have been investigated for their role in creating enzyme inhibitors and receptor ligands. These applications leverage the compound's structural features to develop novel therapeutic agents targeting specific biological pathways.

The growing interest in H-Thr-OMe.HCl has also spurred advancements in its production methods. Manufacturers are continuously refining synthetic routes to improve yield and purity while reducing costs. These efforts align with broader industry trends aimed at making peptide-based therapeutics more accessible and affordable. As a result, researchers now have access to high-quality H-Thr-OMe.HCl that meets stringent regulatory standards for clinical trials and commercial applications.

In conclusion, H-Thr-OMe.HCl (CAS No. 39994-75-7) is a versatile and indispensable compound in modern pharmaceutical research. Its role as a protected threonine derivative makes it invaluable for peptide synthesis, drug development, and biotechnological applications. With ongoing advancements in synthetic methodologies and growing demand for peptide-based therapeutics, this compound will continue to be at the forefront of biochemical innovation.

• 62062-63-9(L-Threonine, butyl ester, hydrochloride)
• 33368-36-4(Threonine, ethyl ester,hydrochloride (1:1))
• 60538-18-3(methyl (2R,3R)-2-amino-3-hydroxy-butanoate;hydrochloride)
• 62076-66-8(Dl-threonine methyl ester hydrochloride)
• 62365-20-2(D-Threonine, ethyl ester, hydrochloride)
• 79617-27-9(L-allo-Threonine methyl ester hydrochloride)
• 82679-55-8(methyl (2R,3S)-2-amino-3-hydroxybutanoate)
• 3373-59-9((2S,3R)-methyl 2-amino-3-hydroxybutanoate)
• 39994-70-2(Ethyl (2R,3R)-2-amino-3-hydroxybutanoate;hydrochloride)
• 60538-15-0(D-Threonine Methyl Ester Hydrochloride)