Production Method 1

3764-01-0

6921-34-2

796095-89-1

Reaction Conditions

1.1 Catalysts: (Bis(diphenylphosphino)ethane)dichloronickel Solvents: Tetrahydrofuran ;  12 h, rt
1.2 Reagents: Ammonium chloride Solvents: Water ;  rt

Reference

Discovery of 2,4-diaminopyrimidine derivatives targeting p21-activated kinase 4: Biological evaluation and docking studies

Qin, Qiaohua; Wu, Tianxiao; Yin, Wenbo; Sun, Yixiang; Zhang, Xiangyu; et al, Archiv der Pharmazie (Weinheim, 2020, 353(10),

Production Method 2

13345-11-4

796095-89-1

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride Solvents: N,N-Dimethylaniline ;  3 h, 100 °C

Reference

Synthesis and evaluation of the 2,4-diaminoquinazoline series as anti-tubercular agents

Odingo, Joshua; O'Malley, Theresa; Kesicki, Edward A.; Alling, Torey; Bailey, Mai Ann; et al, Bioorganic & Medicinal Chemistry, 2014, 22(24), 6965-6979

4-Benzyl-2,6-dichloropyrimidine Raw materials

• 2,4,6-Trichloropyrimidine
• 6-benzylpyrimidine-2,4(1H,3H)-dione
• Benzylmagnesium chloride

4-Benzyl-2,6-dichloropyrimidine Preparation Products

• 4-Benzyl-2,6-dichloropyrimidine (796095-89-1)

• 1. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 2. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
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• 3. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
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• 4. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
• 5. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Halopyrimidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Halopyrimidines

• 140702-98-3(Pyrimidine, 4-chloro-2,6-bis(phenylmethyl)-)
• 927679-36-5(3-((2,6-dichloropyrimidin-4-yl)methyl)benzonitrile)
• 168150-96-7(4-benzyl-2-chloro-pyrimidine)
• 656822-36-5(Pyrimidine, 2,4-dichloro-6-(2-phenylethyl)-)
• 134340-13-9(4-benzyl-6-chloropyrimidine)
• 89938-05-6(2,4-dichloro-6-(propan-2-yl)pyrimidine)
• 6554-65-0(2,4-dichloro-6-ethylpyrimidine)
• 825647-54-9(Pyrimidine, 2,4-dichloro-6-[(4-methoxyphenyl)methyl]-)
• 927679-51-4(2,4-dichloro-6-(3-fluorobenzyl)pyrimidine)
• 630125-76-7(Benzenamine, 4-[(6-chloro-4-pyrimidinyl)methyl]-)