Production Method 1

78191-00-1

372-48-5

79574-70-2

Reaction Conditions

1.1 Reagents: Butyllithium ,  Diisopropylethylamine Solvents: Tetrahydrofuran ,  Hexane ;  -40 °C; 30 min, -40 °C; -40 °C → -70 °C
1.2 -70 °C; 30 min, -70 °C
1.3 Solvents: Tetrahydrofuran ;  < -60 °C; 30 min, -70 °C
1.4 Reagents: Hydrochloric acid Solvents: Water

Reference

A facile synthesis of 2,3-disubstituted furo[2,3-b]pyridines

Beutner, Gregory L.; Kuethe, Jeffrey T.; Yasuda, Nobuyoshi, Tetrahedron Letters, 2009, 50(7), 781-784

Production Method 2

79574-61-1

79574-70-2

Reaction Conditions

1.1 Reagents: Chromium trioxide

Reference

Regioselective metalation in the pyridine series: original synthesis of 3-aroyl-2-aminopyridines

Gungor, Timur; Marsais, Francis; Queguiner, Guy, Journal of Organometallic Chemistry, 1981, 215(2), 139-50

3-Acetyl-2-fluoropyridine Raw materials

• N-Methoxy-N-methylacetamide
• 1-(2-Fluoropyridin-3-yl)ethanol
• 2-Fluoropyridine

3-Acetyl-2-fluoropyridine Preparation Products

• 3-Acetyl-2-fluoropyridine (79574-70-2)

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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones
• Solvents and Organic Chemicals Organic Compounds

• 36404-90-7(2-fluoropyridine-3-carbaldehyde)
• 885132-93-4(1-Propanone,1-(2,6-difluoro-3-pyridinyl)-)
• 84331-14-6(1-(6-Fluoropyridin-3-yl)ethanone)
• 949154-24-9(2-chloro-1-(2-fluoropyridin-3-yl)ethan-1-one)
• 949154-27-2(1-(6-fluoro-3-pyridinyl)-1-Propanone)
• 871325-14-3(5-ethyl-2-fluoro-3-Pyridinecarboxaldehyde)
• 155601-65-3(2,6-Difluoronicotinaldehyde)
• 920036-27-7(1-(2,6-Difluoropyridin-3-yl)ethanone)
• 145005-30-7(Ethanone,2-fluoro-1-(2-fluoro-3-pyridinyl)-)
• 1138033-53-0(2-Bromo-1-(2-Fluoropyridin-3yl)ethanone)