Production Method 1

727-55-9

79538-03-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Isopropanol ;  1.5 MPa, rt → 100 °C

Reference

Improved synthesis of tefluthrin

He, Shu-ze, Xiandai Nongyao, 2015, 14(2), 28-30

Production Method 2

99705-45-0

79538-03-7

Reaction Conditions

1.1 Reagents: Magnesium oxide ,  Hydrogen Catalysts: Palladium Solvents: Methanol ,  Water ;  rt → 50 °C; 6 h, 50 °C; cooled

Reference

Synthesis of 4-methyl-2,3,5,6-tetrafluorobenzenemethanol

He, Mingyang; Chen, Shengchun; Xie, Yingmei; Chen, Qun, Huagong Jinzhan, 2006, 25(7), 811-814

Production Method 3

99705-46-1

79538-03-7

Reaction Conditions

1.1 Reagents: Magnesium oxide ,  Hydrogen Catalysts: Palladium Solvents: Methanol ,  Water ;  60 - 90 min, 2.5 bar, 50 °C

Reference

Process for the manufacture of Tefluthrin

Anonymous, Research Disclosure, 2004, 478,

Production Method 4

92339-07-6

79538-03-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Octane ;  rt → 160 °C; 15 h, 1.0 MPa, 150 - 160 °C

Reference

Synthesis of 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol

Yuan, Qi-liang; Qian, Jie; Shi, Zheng-jun; Bao, Zhang-feng; Zeng, Jun, Huaxue Shijie, 2014, 55(5), 285-288

Production Method 5

5230-78-4

79538-03-7

Reaction Conditions

1.1 Reagents: Chloro(1-methylethyl)magnesium Solvents: Tetrahydrofuran ;  12 h, rt
1.2 rt
1.3 Reagents: Methanol ;  rt; 30 min, rt

Reference

Mg-Prompted Polyfluoroarene C-H Functionalization: Formal Synthesis of Transfluthrin, Fenfluthrin, and Tefluthrin

Jia, Xuejiao; Wang, Junya; Ding, Xue; Yang, Jun; Li, Nan; et al, Journal of Organic Chemistry, 2015, 80(21), 10874-10882

2,3,5,6-Tetrafluoro-4-methylbenzyl Alcohol Raw materials

• 2,3,5,6-Tetrafluoro-1,4-benzenedimethanol
• Benzene,1,2,4,5-tetrafluoro-3-methyl-
• Benzenemethanol, 4-(bromomethyl)-2,3,5,6-tetrafluoro-
• 1,4-Benzenedicarboxylic acid, 2,3,5,6-tetrafluoro-, dimethyl ester
• Benzenemethanol, 4-(chloromethyl)-2,3,5,6-tetrafluoro-

2,3,5,6-Tetrafluoro-4-methylbenzyl Alcohol Preparation Products

• 2,3,5,6-Tetrafluoro-4-methylbenzyl Alcohol (79538-03-7)

• 1. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 2. An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
  Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
• 3. An amorphous Cu–In–S nanoparticle-based precursor ink with improved atom economy for CuInSe2 solar cells with 10.85% efficiency?
  Green Chem., 2017,19, 1268-1277
• 4. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003
• 5. An Assessment of the Laminar Hypersonic Double-Cone Experiments in the LENS-XX Tunnel
  JaideepRay,PatrickBlonigan,EricT.Phipps,KathrynMaupin

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyl alcohols
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Introduction to 2,3,5,6-Tetrafluoro-4-methylbenzyl Alcohol (CAS No. 79538-03-7)

2,3,5,6-Tetrafluoro-4-methylbenzyl Alcohol, identified by its Chemical Abstracts Service (CAS) number 79538-03-7, is a fluorinated aromatic alcohol that has garnered significant attention in the field of pharmaceutical chemistry and materials science. This compound belongs to a class of molecules characterized by the presence of multiple fluorine atoms substituting hydrogen atoms on a benzene ring, which imparts unique electronic and steric properties. The introduction of fluorine atoms can significantly alter the chemical reactivity, metabolic stability, and pharmacokinetic profiles of molecules, making such derivatives highly valuable in drug development.

The structural motif of 2,3,5,6-Tetrafluoro-4-methylbenzyl Alcohol consists of a benzene ring substituted with four fluorine atoms at the 2, 3, 5, and 6 positions, along with a methyl group at the 4-position and a hydroxyl group at the 4-position as well. This specific arrangement creates a molecule with enhanced lipophilicity and metabolic stability, which are critical factors in designing bioactive compounds. The presence of fluorine atoms also influences the electronic properties of the aromatic system, potentially affecting its interaction with biological targets.

In recent years, there has been a surge in research focusing on fluorinated aromatic compounds due to their potential applications in medicinal chemistry. The ability to fine-tune the electronic and steric properties of these molecules allows for the development of more potent and selective drug candidates. For instance, studies have demonstrated that fluorine substitution can improve binding affinity to biological targets by modulating hydrophobic interactions and charge distribution. This has led to the exploration of 2,3,5,6-Tetrafluoro-4-methylbenzyl Alcohol as a building block for synthesizing novel pharmacophores.

One notable area where this compound has shown promise is in the development of antiviral agents. The unique structural features of 2,3,5,6-Tetrafluoro-4-methylbenzyl Alcohol make it an attractive candidate for designing inhibitors targeting viral proteases and polymerases. Recent studies have highlighted its role in synthesizing analogs that exhibit enhanced resistance to degradation by enzymatic processes. This property is particularly crucial in antiviral therapy, where maintaining stability under physiological conditions is essential for prolonged activity.

Additionally, the compound has found applications in materials science due to its ability to impart specific properties to polymers and coatings. Fluorinated aromatic alcohols can act as monomers or additives that enhance thermal stability and chemical resistance. For example, research has shown that incorporating 2,3,5,6-Tetrafluoro-4-methylbenzyl Alcohol into polymer matrices can improve their performance under extreme conditions such as high temperatures or corrosive environments. This makes it a valuable component in developing advanced materials for industrial applications.

The synthesis of 2,3,5,6-Tetrafluoro-4-methylbenzyl Alcohol typically involves multi-step organic reactions that require careful optimization to achieve high yields and purity. Common synthetic routes include halogenation followed by nucleophilic substitution or metal-catalyzed cross-coupling reactions. The introduction of fluorine atoms often necessitates specialized conditions due to their high electronegativity and reactivity. However, advances in synthetic methodologies have made it possible to produce this compound efficiently on both laboratory and industrial scales.

In terms of biological activity, 2,3,5,6-Tetrafluoro-4-methylbenzyl Alcohol has been investigated for its potential role as an intermediate in synthesizing bioactive molecules. Its benzyl alcohol moiety is a well-known pharmacophore that can participate in various biochemical interactions. For instance, it has been used in the synthesis of protease inhibitors targeting diseases such as cancer and inflammation. The fluorinated aromatic ring further enhances its utility by providing additional interaction points with biological targets.

Recent research has also explored the use of 2,3,5,6-Tetrafluoro-4-methylbenzyl Alcohol in developing fluorescent probes for cellular imaging. Fluorinated aromatic compounds are known for their ability to emit light when excited by UV or visible light sources. This property makes them ideal candidates for creating probes that can visualize biological processes within living cells. Studies have demonstrated successful applications in tracking protein-protein interactions and monitoring metabolic pathways using derivatives of this compound.

The industrial significance of 2,3,5,6-Tetrafluoro-4-methylbenzyl Alcohol cannot be overstated. Its versatility as a building block for pharmaceuticals and advanced materials underscores its importance in modern chemistry. As research continues to uncover new applications for fluorinated aromatic compounds like this one? industries are likely to see increased demand for high-quality synthetic intermediates capable of meeting stringent purity standards.

In conclusion，2，3，5，6-Tetrafluoro-4-methylbenzyl Alcohol (CAS No．79538—03—7) represents a fascinating example of how structural modifications can lead to novel applications across multiple disciplines．Its unique combination of electronic、steric，and metabolic properties makes it an invaluable asset for researchers working on drug development、materials science，and beyond．As our understanding of fluorinated organic chemistry evolves，we can expect even more innovative uses for this remarkable compound．

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• 114152-19-1(2,3,6-Trifluorobenzyl Alcohol)
• 144284-24-2(2,3,4-Trifluorobenzyl Alcohol)
• 83282-91-1(4-Methoxymethyl-2,3,5,6-tetrafluorobenzyl Alcohol)
• 67640-33-9(2,3,5-Trifluorobenzyl Alcohol)
• 92339-07-6(2,3,5,6-Tetrafluoro-1,4-benzenedimethanol)
• 144284-25-3(2,4,5-Trifluorobenzyl alcohol)
• 53072-18-7(2,3,4,5-Tetrafluorobenzyl alcohol)
• 4084-38-2(2,3,5,6-Tetrafluorobenzyl alcohol)
• 440-60-8((Hydroxymethyl)pentafluorobenzene)