Production Method 1

39270-39-8

79440-34-9

Reaction Conditions

1.1 Reagents: Boron tribromide Solvents: Dichloromethane ;  rt; 8 h, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  pH 7, rt

Reference

Synthesis of phenylpiperazine derivatives of 1,4-benzodioxan as selective COX-2 inhibitors and anti-inflammatory agents

Sun, Juan; Wang, Su; Sheng, Gui-Hua; Lian, Zhi-Min; Liu, Han-Yu; et al, Bioorganic & Medicinal Chemistry, 2016, 24(21), 5626-5632

Production Method 2

39270-39-8

79440-34-9

Reaction Conditions

1.1 Reagents: Phosphorus tribromide Solvents: Dichloromethane ;  15 min, 0 - 5 °C; 5 h, 0 - 5 °C

Reference

Synthesis, antimycobacterial and antibacterial activity of ciprofloxacin derivatives containing a N-substituted benzyl moiety

Wang, Shuo; Jia, Xue-Dong; Liu, Ming-Liang; Lu, Yu; Guo, Hui-Yuan, Bioorganic & Medicinal Chemistry Letters, 2012, 22(18), 5971-5975

Production Method 3

39270-39-8

79440-34-9

Reaction Conditions

1.1 Reagents: Carbon tetrabromide ,  Triphenylphosphine Solvents: Dichloromethane ;  20 h, rt

Reference

Synthesis and antitumor activity of novel hybrid compounds between 1,4-benzodioxane and imidazolium salts

Liu, Zhengfen ; Zhang, Yaguan; Dong, Jianwei; Fang, Yongsheng; Jiang, Yonggang; et al, Archiv der Pharmazie (Weinheim, 2022, 355(10),

Production Method 4

39270-39-8

79440-34-9

Reaction Conditions

1.1 Reagents: Phosphorus tribromide Solvents: Dichloromethane ;  cooled; 30 min, 0 °C

Reference

Synthesis and in vitro antibacterial activity of gemifloxacin derivatives containing a substituted benzyloxime moiety

Feng, Lianshun; Lv, Kai; Liu, Mingliang; Wang, Shuo; Zhao, Jing; et al, European Journal of Medicinal Chemistry, 2012, 55, 125-136

Production Method 5

29668-44-8

79440-34-9

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Methanol
1.2 Reagents: N-Bromosuccinimide ,  Triphenylphosphine Solvents: Dimethylformamide

Reference

Synthesis of isoquinolines and tetrahydroisoquinolines as potential antitumor agents

Capilla, A. S.; Romero, M.; Pujol, M. D.; Caignard, D. H.; Renard, P., Tetrahedron, 2001, 57(39), 8297-8303

6-(Bromomethyl)-2,3-dihydrobenzob1,4dioxine Raw materials

• 2,3-dihydro-1,4-benzodioxine-6-carbaldehyde
• 2,3-Dihydro-1,4-benzodioxin-6-ylmethanol

6-(Bromomethyl)-2,3-dihydrobenzob1,4dioxine Preparation Products

• 6-(Bromomethyl)-2,3-dihydrobenzob1,4dioxine (79440-34-9)

• 1. Excimer–monomer switch: a reaction-based approach for selective detection of fluoride?
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• 5. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzodioxanes Benzo-1,4-dioxanes

• 72724-00-6(Benzene,4-(bromomethyl)-2-methoxy-1-(phenylmethoxy)-)
• 172900-73-1(4-(Bromomethyl)-1-methoxy-2-(3-methoxypropoxy)benzene)
• 560086-30-8(Benzene, 1,1'-[1,2-ethanediylbis(oxy)]bis[3-(bromomethyl)-)
• 214894-89-0(5-(Bromomethyl)-2,3-dihydro-1,4-benzodioxine)
• 3898-24-6(1-(bromomethyl)-3-ethoxy-benzene)
• 918446-56-7(Benzene, 5-(bromomethyl)-2-methoxy-1,3-bis(1-methylethoxy)-)
• 21852-32-4(4-(Bromomethyl)-1,2-dimethoxybenzene)
• 55667-12-4(2-(BENZYLOXY)-4-(BROMOMETHYL)-1-METHOXYBENZENE)
• 106341-33-7(Benzene, 1-(bromomethyl)-4-(2-methoxyethoxy)-)
• 111394-51-5(5-(bromomethyl)-2-methoxyphenol)