Production Method 1

1003-04-9

79107-75-8

Reaction Conditions

1.1 Catalysts: Alcohol dehydrogenase

Reference

Enzymes in organic syntheses. 19. Evaluation of the stereoselectivities of horse liver alcohol dehydrogenase; catalyzed oxidoreductions of hydroxy- and ketothiolanes, -thianes, and -thiepanes

Jones, J. Bryan; Schwartz, Harold M., Canadian Journal of Chemistry, 1981, 59(11), 1574-9

Production Method 2

1120-59-8

79107-75-8

Reaction Conditions

1.1 Reagents: Bis[(1R,2S,3R,5R)-2,6,6-trimethylbicyclo[3.1.1]hept-3-yl]borane Solvents: Tetrahydrofuran
1.2 Reagents: Acetaldehyde
1.3 Reagents: Sodium hydroxide ,  Hydrogen peroxide Solvents: Tetrahydrofuran

Reference

Chiral synthesis via organoboranes. 6. Hydroboration. 74. Asymmetric hydroboration of representative heterocyclic olefins with diisopinocampheylborane. Synthesis of heterocyclic boronates and heterocyclic alcohols of very high enantiomeric purity

Brown, Herbert C.; Prasad, J. V. N. Vara, Journal of the American Chemical Society, 1986, 108(8), 2049-54

Production Method 3

1003-04-9

79107-75-8

100937-75-5

Reaction Conditions

1.1 Catalysts: NADPH ,  Alcohol dehydrogenase

Reference

Catalytic Asymmetric Reduction of Difficult-to-Reduce Ketones: Triple-Code Saturation Mutagenesis of an Alcohol Dehydrogenase

Sun, Zhoutong; Lonsdale, Richard; Ilie, Adriana; Li, Guangyue; Zhou, Jiahai; et al, ACS Catalysis, 2016, 6(3), 1598-1605

Production Method 4

61847-07-2

79107-75-8

Reaction Conditions

1.1 Reagents: Disodium sulfide Solvents: Acetonitrile ;  14 h, rt

Reference

Synthesis of a variety of optically active hydroxylated heterocyclic compounds using epoxide hydrolase technology

Pienaar, Daniel P.; Mitra, Robin K.; van Deventer, Thomas I.; Botes, Adriana L., Tetrahedron Letters, 2008, 49(48), 6752-6755

Production Method 5

1003-04-9

79107-75-8

Reaction Conditions

1.1 Reagents: NADPH Catalysts: Short-chain dehydrogenase/reductase SDR Solvents: Isopropanol ,  Water ;  12 h, pH 7, 30 °C

Reference

Enantioselective Regulation of Short-Chain Dehydrogenases via Key Sites in its Loop and Adjacent Regions for the Enantiodivergent Reduction of Difficult-To-Reduce Ketones

Qin, Lei; Su, Xin; Wang, Jun; Wu, Lunjie ; Zou, Man; et al, Advanced Synthesis & Catalysis, 2023, 365(23), 4205-4215

Production Method 6

1003-04-9

79107-75-8

Reaction Conditions

1.1 Solvents: Isopropanol ,  Water ;  12 h, pH 7, 30 °C

Reference

Regulating the stereoselectivity of medium-chain dehydrogenase/reductase by creating an additional active pocket accommodating prochiral heterocyclic ketones

Qin, Lei; Su, Xin; Wang, Jun; Wu, Lunjie; Zou, Man; et al, Chemical Communications (Cambridge, 2023, 59(87), 13042-13045

(3S)-thiolan-3-ol Raw materials

• thiolan-3-one
• Thiophene, 2,3-dihydro-
• (2S)-2-(2-bromoethyl)oxirane

(3S)-thiolan-3-ol Preparation Products

• (3S)-thiolan-3-ol (79107-75-8)
• (3R)-thiolan-3-ol (100937-75-5)

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• 4. Excited state potential energy surfaces and their interactions in FeIVO active sites
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Thiolanes Thiolanes
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Thiolanes

• 18023-86-4(1,2-Propanediol,3-(dodecylthio)-)
• 51026-30-3(2-Dodecanol, 1-[(2-hydroxyethyl)thio]-)
• 85099-04-3(1,2-Propanediol,3-(butylthio)-)
• 66168-52-3(1,2-Propanediol, 3-[(2-hydroxytetradecyl)thio]-)
• 219519-54-7(2,3-Butanediol, 1,4-bis(methylthio)-, (2R,3R)-rel-)
• 79107-71-4(3-Hydroxytetrahydrothiophene)
• 3976-75-8(3,4-Thiophenediol, tetrahydro-, (3R,4S)-rel-)
• 3334-05-2(Tetrahydrothiophen-3-ol)
• 86827-92-1(THIOLANEDIOL)
• 100937-75-5((3R)-thiolan-3-ol)