Production Method 1

472-80-0

79-77-6

Reaction Conditions

1.1 Catalysts: Bromopentacarbonylmanganese ,  N-Methyl-N-(2-pyridinylmethyl)-2-pyridinemethanamine Solvents: Toluene ;  30 min, 90 °C
1.2 Reagents: Acetone Catalysts: Sodium tert-butoxide Solvents: Toluene ;  24 h, 90 °C

Reference

Transfer-dehydrogenation of secondary alcohols catalyzed by manganese NNN-pincer complexes

Budweg, Svenja; et al, Chemical Communications (Cambridge, 2019, 55(94), 14143-14146

Production Method 2

141-10-6

79-77-6

Reaction Conditions

1.1 Reagents: 2-Hydroxy-4-octoxybenzophenone ,  Sulfuric acid Solvents: 1,1,1-Trichloroethane

Reference

Synthesis of high purity beta-ionone via Claisen-Schmidt condensation of citral with acetone

, China, , ,

Production Method 3

22029-76-1

79-77-6

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  Potassium persulfate Catalysts: Nickel sulfate (NiSO4) Solvents: Dichloromethane ,  Water

Reference

Nickel-catalyzed oxidation of allylic alcohols with K2S2O8

Yamazaki, Shigekazu; et al, Chemistry Letters, 1989, (8), 1361-4

Production Method 4

79-77-6

Reaction Conditions

Reference

Deprotection of S,S-acetals

Firouzabadi, H.; et al, Science of Synthesis, 2007, 30, 505-586

Production Method 5

79-77-6

Reaction Conditions

1.1 Reagents: Iodine ,  Water Solvents: 1,4-Dioxane ;  24 h, reflux; reflux → rt
1.2 Reagents: Sodium thiosulfate Solvents: Water

Reference

Iodine/water-mediated deprotective oxidation of allylic ethers to access α,β-unsaturated ketones and aldehydes

Xue, Yuntian; et al, RSC Advances, 2020, 10(25), 14720-14724

Production Method 6

917-54-4

884845-78-7

79-77-6

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  -78 °C

Reference

Accurate Measurements of 13C-13C J-Couplings in the Rhodopsin Chromophore by Double-Quantum Solid-State NMR Spectroscopy

Lai, Wai Cheu; et al, Journal of the American Chemical Society, 2006, 128(12), 3878-3879

Production Method 7

127-41-3

79-77-6

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid ,  Sulfuric acid

Reference

Novel cyclizing agents in β-ionone synthesis from pseudoionone

Markovich, Yu. D.; et al, Khimiko-Farmatsevticheskii Zhurnal, 1998, 32(11), 36-38

Production Method 8

472-80-0

79-77-6

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Lanthanum iodide ,  4-Methoxy-5-tert-butyl-1,2-benzoquinone Solvents: Acetonitrile ;  1 h, 1 atm, rt

Reference

A bio-inspired lanthanum-ortho quinone catalyst for aerobic oxidation of alcohol

Zhang, Ruipu; et al, ChemRxiv, 2020, 1, 1-19

Production Method 9

472-80-0

79-77-6

Reaction Conditions

1.1 Reagents: Dimethyl sulfoxide ,  7,7-Dichloro-1,3,5-cycloheptatriene Solvents: Dichloromethane ;  20 min, -30 °C
1.2 20 min, -30 °C
1.3 Reagents: Triethylamine ;  -30 °C; 20 min, -30 °C → rt

Reference

Activation of DMSO for Swern-type oxidation by 1,1-dichlorocycloheptatriene

Nguyen, Thanh Vinh; et al, Tetrahedron Letters, 2014, 55(50), 6895-6898

Production Method 10

917-54-4

14393-45-4

79-77-6

Reaction Conditions

1.1 Solvents: Diethyl ether

Reference

Substances with the odor of violets. LVI. α- and β-Cyclocitrylideneacetic acids and some related compounds

de Tribolet, P.; et al, Helvetica Chimica Acta, 1954, 37, 1798-1804

Production Method 11

33073-36-8

79-77-6

Reaction Conditions

1.1 Catalysts: Sulfuric acid ;  25 °C

Reference

Sulfuric acid

Krow, Grant R., e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, 1, 1-4

Production Method 12

33073-36-8

79-77-6

Reaction Conditions

1.1 Catalysts: Sulfuric acid ;  25 °C

Reference

Sulfuric Acid

Krow, Grant R., e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, ,

Production Method 13

2302-89-8

79-77-6

Reaction Conditions

1.1 Solvents: Water

Reference

Volatile plant materials. XXVI. Ionones

Naves, Y. R.; et al, Helvetica Chimica Acta, 1943, 26, 2151-65

Production Method 14

3548-78-5

79-77-6

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Nitromethane

Reference

Chemistry of unsaturated ethers. VII. Addition of the acetal of β-C14-aldehyde to 1-ethoxy-2-methyl-1,3-butadiene. A new synthesis of β-C19-aldehyde

Makin, S. M.; et al, Zhurnal Obshchei Khimii, 1961, 31, 3319-23

Production Method 15

79-77-6

Reaction Conditions

1.1 Reagents: Periodic acid Solvents: Tetrahydrofuran

Reference

Deblocking of dithioacetals and oxathioacetals using periodic acid under mild nonaqueous conditions

Shi, Xiao-Xin; et al, Tetrahedron Letters, 1996, 37(25), 4331-4334

Production Method 16

141208-06-2

79-77-6

Reaction Conditions

1.1 Solvents: Toluene ,  Tetrahydrofuran ;  0 °C; 2 h, 0 °C → rt; 18 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  rt

Reference

Photocatalytic E → Z Isomerization of β-Ionyl Derivatives

Livingstone, Keith; et al, Organic Letters, 2019, 21(23), 9677-9680

Production Method 17

99747-72-5

79-77-6

Reaction Conditions

1.1 Reagents: Triethylamine Catalysts: Dichlorobis(triphenylphosphine)palladium Solvents: Dimethylformamide

Reference

Palladium-catalyzed synthesis of β-ionone from 2,2,6-trimethylcyclohexanone

Breining, Tibor; et al, Synthetic Communications, 1987, 17(1), 85-8

Production Method 18

14398-32-4

79-77-6

Reaction Conditions

1.1 Reagents: Lithium chloride Solvents: Dimethyl sulfoxide ,  Water

Reference

A mild and efficient method for selective cleavage of ketals and acetals using lithium chloride in water-dimethyl sulfoxide

Mandal, Pijus Kumar; et al, Tetrahedron Letters, 1997, 38(41), 7271-7274

Production Method 19

3548-78-5

13927-47-4

79-77-6

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Nitromethane

Reference

Synthesis of retinals labeled with carbon-13 in the cyclohexene ring

Gebhard, R.; et al, Recueil des Travaux Chimiques des Pays-Bas, 1989, 108(6), 207-14

Production Method 20

339148-59-3

79-77-6

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Hexane ,  Water
1.2 Reagents: Sodium hydroxide Solvents: Water

Reference

Synthesis of β-ionone

Vani, Parimi V. S. N.; et al, Synthetic Communications, 2001, 31(2), 219-224

beta-Ionone, synthetic Raw materials

• 1,3-Dioxolane,2-methyl-2-[(1E)-2-(2,6,6-trimethyl-1-cyclohexen-1-yl)ethenyl]-
• Methanesulfonic acid, trifluoro-, 2,6,6-trimethyl-1-cyclohexen-1-yl ester
• Methyllithium (1.6M in Diethyl Ether)
• (3E,5E)-6,10-dimethylundeca-3,5,9-trien-2-one
• 5,9-Undecadien-2-one, 4-hydroxy-6,10-dimethyl-, (5Z)-
• 3,5,10-Undecatrien-2-one, 6,10-dimethyl-, (3E,5E)-
• a-Ionone (>90%)
• 3-Buten-2-ol, 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (3E)-
• (2E)-3-(2,6,6-trimethylcyclohex-1-en-1-yl)prop-2-enoic acid
• Hydrazinecarboxamide,2-[1-methyl-3-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2-propen-1-ylidene]-
• 3,5,9-Undecatrien-2-one,6,10-dimethyl-
• 3-Buten-2-ol,4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-
• 3,5,9-Undecatrien-2-one, 6,10-dimethyl-, (E,Z)-
• 2-Propenamide,N-methoxy-N-methyl-3-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (E)-

beta-Ionone, synthetic Preparation Products

• beta-Ionone, synthetic (79-77-6)

• 1. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 2. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 3. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 4. Excellent humidity sensor based on ultrathin HKUST-1 nanosheets?
  Qiaoe Wang,Meiling Lian,Xiaowen Zhu,Xu Chen RSC Adv., 2021,11, 192-197
• 5. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Prenol lipids Sesquiterpenoids Sesquiterpenoids
• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Prenol lipids Sesquiterpenoids
• Natural Products and Extracts Plant Extracts Plant based Rhanterium epapposum
• Natural Products and Extracts Plant Extracts Plant based Erucaria microcarpa
• Sesquiterpenoids

Comprehensive Guide to beta-Ionone, synthetic (CAS No. 79-77-6): Properties, Applications, and Industry Trends

beta-Ionone, synthetic (CAS No. 79-77-6) is a highly versatile organic compound widely recognized for its floral, woody, and violet-like aroma. As a key ingredient in the fragrance and flavor industries, this molecule has garnered significant attention due to its unique sensory properties and broad applicability. The compound’s chemical structure, characterized by a cyclic ketone with an unsaturated side chain, contributes to its distinct olfactory profile, making it indispensable in perfumery and food flavoring.

In recent years, the demand for synthetic beta-Ionone has surged, driven by trends in clean-label fragrances and sustainable sourcing. Consumers are increasingly seeking transparency in ingredient lists, prompting manufacturers to explore high-purity synthetic alternatives like CAS 79-77-6 to meet regulatory and ethical standards. This shift aligns with the growing popularity of vegan cosmetics and eco-friendly formulations, where synthetic compounds often outperform natural extracts in consistency and scalability.

The synthesis of beta-Ionone typically involves the condensation of citral with acetone, followed by cyclization—a process refined to achieve high yields and minimal impurities. Advanced chromatographic techniques ensure the final product meets stringent quality benchmarks, particularly for use in premium perfumes and gourmet flavorings. Researchers have also explored enzymatic pathways to produce beta-Ionone, addressing the industry’s push toward green chemistry and reduced carbon footprints.

Beyond its traditional roles, beta-Ionone (CAS 79-77-6) is gaining traction in niche markets such as functional fragrances for aromatherapy and mood-enhancing products. Studies suggest its olfactory properties may influence emotional well-being, a topic frequently searched in connection with psychoactive scents and holistic wellness. This intersection of science and sensory experience positions synthetic beta-Ionone as a compound of interest for innovators in personal care and therapeutic applications.

From an industrial perspective, the supply chain for CAS 79-77-6 remains robust, with major producers focusing on GMP-certified manufacturing to cater to pharmaceutical and food-grade applications. Regulatory bodies like the FDA and EFSA have evaluated its safety, further solidifying its status as a preferred choice for food additives and cosmetic preservatives. However, ongoing research into allergenicity and biodegradability reflects the industry’s commitment to addressing consumer concerns about synthetic vs. natural ingredients.

In conclusion, beta-Ionone, synthetic (CAS No. 79-77-6) exemplifies the synergy between chemistry and consumer needs. Its adaptability across fragrances, flavors, and emerging wellness markets underscores its enduring relevance. As sustainability and transparency dominate industry dialogues, this compound’s synthetic versatility ensures it will remain a cornerstone of modern formulation science.

• 14901-07-6(β-Ionone)
• 79718-73-3(3-Buten-2-one, 4-(2,4,4-trimethylbicyclo[4.1.0]hept-2-en-3-yl)-, (E)-)
• 89128-16-5(3-Penten-2-one, 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (Z)-)
• 89128-17-6(3-Penten-2-one, 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (E)-)
• 53402-96-3(3,5,7-Octatrien-2-one, 6-methyl-8-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (E,Z,E)- (9CI))
• 3604-90-8(Citranxanthin)
• 8013-90-9(Ionone)
• 35031-06-2(3-Buten-2-one,4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (3Z)-)
• 56013-14-0(3,5-Hexadien-2-one, 4-methyl-6-(2,6,6-trimethyl-1-cyclohexen-1-yl)-,(E,E)-)
• 79-70-9(3-Buten-2-one,4-(2,5,6,6-tetramethyl-1-cyclohexen-1-yl)-)