Sesquiterpenoids are a class of naturally occurring terpenoid compounds characterized by containing 15 carbon atoms in their basic structure, forming five isoprene units. These secondary metabolites are widely distributed in plants and fungi, playing crucial roles in various biological processes such as defense against pathogens, signaling pathways, and chemical communication. They exhibit diverse biological activities including anti-inflammatory, antioxidant, antiviral, and anticancer properties, making them of great interest to researchers in the field of natural products chemistry. Due to their complex structures, sesquiterpenoids are often challenging to synthesize through traditional chemical methods, which has led to significant efforts in discovering and isolating these compounds from nature for potential medicinal applications.