Production Method 1

645-36-3

78902-09-7

Reaction Conditions

1.1 Solvents: Ethyl acetate

Reference

Synthesis and evaluation of sulfonylhydrazones of phthalimidoacetaldehyde as anticancer agents

Charya, Sudin Bbhatta; Dutta, Susanta; Sanyal, Utpal, Journal of the Indian Chemical Society, 1998, 75(1), 46-48

Production Method 2

645-36-3

524-38-9

78902-09-7

Reaction Conditions

1.1 Solvents: Water ;  12 h, pH 7, rt

Reference

A phthalimidation protocol that follows protein defined parameters

Singudas, Rohith; Adusumalli, Srinivasa Rao; Joshi, Pralhad Namdev; Rai, Vishal, Chemical Communications (Cambridge, 2015, 51(3), 473-476

Production Method 3

645-36-3

78902-09-7

Reaction Conditions

1.1 Reagents: Diisopropylethylamine Solvents: Toluene

Reference

De Novo Synthesis of a New Diethylenetriaminepentaacetic Acid (DTPA) Bifunctional Chelating Agent

Safavy, Ahmad; Smith, Dale C. Jr.; Bazooband, Alireza; Buchsbaum, Donald J., Bioconjugate Chemistry, 2002, 13(2), 317-326

Production Method 4

645-36-3

78902-09-7

Reaction Conditions

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Toluene ;  2 h, reflux

Reference

Phthalimido-thiazoles as building blocks and their effects on the growth and morphology of Trypanosoma cruzi

Gomes, Paulo Andre Teixeira de Moraes; Oliveira, Arsenio Rodrigues; Cardoso, Marcos Verissimo de Oliveira; Santiago, Edna de Farias; Barbosa, Miria de Oliveira; et al, European Journal of Medicinal Chemistry, 2016, 111, 46-57

Production Method 5

2032-35-1

1074-82-4

78902-09-7

Reaction Conditions

1.1 Solvents: Dimethylformamide

Reference

1-Hydroxyimidazole derivatives. Part II. Synthesis and reactions of 1-benzyloxy-2,3-dihydroimidazole-2-thione. Preparation of 1-benzyloxy-1H-imidazoles

Hauser, H.; Kloetzer, W.; Krug, V.; Rzehak, J.; Sandrieser, A.; et al, Scientia Pharmaceutica, 1988, 56(4), 235-41

Production Method 6

2032-35-1

1074-82-4

78902-09-7

Reaction Conditions

1.1 Solvents: Dimethylformamide ;  4 h, 150 °C

Reference

Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility

Jia, Lanqi; Simpson, Robert D.; Yuan, Jing; Xu, Zhenrong; Zhao, Wei; et al, ACS Medicinal Chemistry Letters, 2011, 2(10), 747-751

Production Method 7

2032-35-1

1074-82-4

78902-09-7

Reaction Conditions

1.1 Solvents: 1,4-Dioxane ;  8 h, reflux; cooled

Reference

Reaction of N-(2,2-dimethoxyethyl)-N-methylamine and its N-functional derivatives with resorcinol and 2-methylresorcinol. Calix[4]resorcinols functionalized on the lower rim

Burilov, A. R.; Gazizov, A. S.; Pudovik, M. A.; Konovalov, A. I., Russian Journal of General Chemistry, 2007, 77(1), 98-102

Production Method 8

2032-35-1

1074-82-4

78902-09-7

Reaction Conditions

1.1 Reagents: Hexadecyltributylphosphonium bromide Solvents: Toluene ;  24 h, 111 °C

Reference

Mimicking peroxidase activity by a manganese(II) complex involving a new asymmetric tetradentate ligand containing both amino and imino groups

Perez-Otero, Yolanda; Fernandez-Garcia, M. Isabel; Gomez-Forneas, Esther; Gonzalez-Riopedre, Gustavo; Maneiro, Marcelino, Journal of Chemistry, 2015, 963152, 963152/1-963152/8

Production Method 9

645-36-3

100-52-7

78902-09-7

Reaction Conditions

Reference

Carbonylation Access to Phthalimides Using Self-Sufficient Directing Group and Nucleophile

Ji, Fanghua; Li, Jianxiao; Li, Xianwei ; Guo, Wei; Wu, Wanqing; et al, Journal of Organic Chemistry, 2018, 83(1), 104-112

Production Method 10

72824-04-5

78902-09-7

Reaction Conditions

1.1 Solvents: Ethyl acetate ;  15 min, reflux
1.2 Reagents: Lauroyl peroxide ;  3 h, reflux

Reference

A Direct Approach to Orthogonally Protected α-Amino Aldehydes

Lamb, Richard; Revil-Baudard, Vincent L.; Zard, Samir Z., Organic Letters, 2019, 21(16), 6352-6356

2-(2,2-Diethoxyethyl)isoindoline-1,3-dione Raw materials

• 2,2-diethoxyethan-1-amine
• Allylboronic acid pinacol ester
• 2-Bromo-1,1-diethoxyethane
• N-Hydroxyphthalimide
• potassium 1,3-dioxo-2,3-dihydro-1H-isoindol-2-ide
• Benzaldehyde

2-(2,2-Diethoxyethyl)isoindoline-1,3-dione Preparation Products

• 2-(2,2-Diethoxyethyl)isoindoline-1,3-dione (78902-09-7)

• 1. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 2. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
  Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
• 3. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 4. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 5. Emerging investigators
  Polym. Chem., 2015,6, 5501-5502

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Isoindoles and derivatives Isoindolones
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Isoindoles and derivatives Isoindolines Isoindolones
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

• 495-69-2(2-(phenylformamido)acetic acid)
• 118-29-6(2-(hydroxymethyl)-2,3-dihydro-1H-isoindole-1,3-dione)
• 134-62-3(Diethyltoluamide)
• 304-17-6(N-Isopropylphthalimide)
• 520-03-6(2-Phenylisoindole-1,3-dione)
• 138-56-7(Trimethobenzamide)
• 340-90-9(N-Phthaloyl-L-glutamic Acid)
• 550-44-7(2-Methylisoindole-1,3-dione)
• 524-38-9(N-Hydroxyphthalimide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)