Cas no 789-61-7 (6-Thio-2'-Deoxyguanosine)

6-Thio-2'-Deoxyguanosine structure
6-Thio-2'-Deoxyguanosine structure
Product Name:6-Thio-2'-Deoxyguanosine
CAS No:789-61-7
MF:C10H13N5O3S
MW:283.306919813156
CID:563444
PubChem ID:329825770
Update Time:2024-10-27

6-Thio-2'-Deoxyguanosine Chemical and Physical Properties

Names and Identifiers

    • Guanosine,2'-deoxy-6-thio-
    • 2′-Deoxy-6-thio Guanosine
    • 2'-Deoxy-6-thio Guanosine
    • 6-THIO-2’-DEOXY-GUANOSINE
    • 6-THIO-2'-DEOXYGUANOSINE
    • 2'-deoxyribo-6-thioguanosine
    • tgdr
    • Thiodeoxyguanosine
    • 2′-Ddeoxy-6-thio-guanosine
    • 2′-Deoxy-6-thioguanosine
    • 2′-Deoxythioguanosine
    • 2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-6-mercaptopurine
    • 2-Amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)-9H-purine-6(1H)-thione (7CI,8CI)
    • 6-Thio-dG
    • NSC 71261
    • KR0RFB46DF
    • 2'-Deoxythioguanosine
    • Thioguanine deoxyriboside
    • beta-Thioguanidine deoxyriboside
    • beta-TGdR
    • 6-Mercaptoguaninedeoxyriboside
    • B-TGdR
    • beta-2'-Deoxy-6-thioguanosine monohydrate
    • 2'Deoxy-6-thioguanosine
    • beta-2'-Deoxythioguanosine
    • 2'-Desoxy-6-thioguanosine
    • beta-2'-Deoxythiol guanosine
    • Thioguanine deoxyriboside (VAN)
    • Thioguanine 9betaD-2'-deoxyriboside
    • BETA-THIOGUANINE DEOXYRIBOSIDE
    • 2'-deoxy-6-thioguanosine
    • 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purine-6-thione
    • Guanosine, 2'-deoxy-6-thio-
    • beta-2'-Deox
    • β-TGdR
    • BRN 1224220
    • HSDB 7074
    • A-TGdR
    • MS-24022
    • 789-61-7
    • CHEMBL3250476
    • 6-thio-dG;-TGdR
    • 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-purine-6-thione
    • thio
    • beta-Thioguanosine deoxyriboside
    • NCI-C01581
    • 2-Amino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purine-6(9H)-thione
    • NSC-71261
    • MFCD00672275
    • 2-AMINO-9-(2-DEOXY-.BETA.-D-ERYTHRO-PENTOFURANOSYL)-6-MERCAPTOPURINE
    • 2-Amino-9-(2-deoxy-.beta.-D-erythropentofuranosyl)-9H-purine-6(1H)-thione
    • AC-32335
    • 2-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,9-dihydro-6H-purine-6-thione
    • 2'-DDEOXY-6-THIO-GUANOSINE
    • 6-Thio-2 inverted exclamation marka-Deoxyguanosine
    • DTXSID4021345
    • ??TGdR
    • UNII-KR0RFB46DF
    • s7757
    • 6-thio-dG;
    • 9H-Purine-6(1H)-thione, 2-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)-
    • F88129
    • SCHEMBL531274
    • NSC71261
    • SCHEMBL9634767
    • 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purine-6-thione
    • CS-0014289
    • HY-18762
    • CCRIS 195
    • CCG-267279
    • 2′-Deoxy-6-thioguanosine (ACI)
    • 9H-Purine-6(1H)-thione, 2-amino-9-(2-deoxy-β-D-erythro-pentofuranosyl)- (7CI, 8CI)
    • 2′-Desoxy-6-thioguanosine
    • β-Thioguanine deoxyriboside
    • DA-49951
    • 2-AMINO-9-[(2R,4S,5R)-4-HYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-1H-PURINE-6-THIONE
    • Ateganosine
    • ateganosine [INN]
    • 6-Thio-2'-Deoxyguanosine
    • Inchi： 1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5+,6+/m0/s1
    • InChI Key： SCVJRXQHFJXZFZ-KVQBGUIXSA-N
    • SMILES： S=C1N=C(N)NC2N([C@H]3C[C@H](O)[C@@H](CO)O3)C=NC1=2
    • BRN： 122

Computed Properties

  • Exact Mass: 283.07400
  • Monoisotopic Mass: 283.07391047 g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 4
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 19
  • Rotatable Bond Count: 2
  • Complexity: 420
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 3
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: -0.8
  • Topological Polar Surface Area: 150
  • Molecular Weight: 283.31

Experimental Properties

  • PSA: 154.30000
  • LogP: 0.29300

6-Thio-2'-Deoxyguanosine Security Information

  • Hazardous Material transportation number：NONH for all modes of transport
  • RTECS：UP0750000
  • Storage Condition：4°C, protect from light

6-Thio-2'-Deoxyguanosine Pricemore >>

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6-Thio-2'-Deoxyguanosine Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Pyridine ,  Trifluoroacetic anhydride ;  cooled; 1 h, cooled
1.2 Reagents: Sodium hydrosulfide ;  0 °C; overnight, rt
1.3 Reagents: Ammonium bicarbonate Solvents: Water ;  6 h, rt
Reference
Novel synthesis of O6-alkylguanine containing oligodeoxyribonucleotides as substrates for the human DNA repair protein, O6-methylguanine DNA methyltransferase (MGMT)
Shibata, Takayuki; Glynn, Nicola; McMurry, T. Brian H.; McElhinney, R. Stanley; Margison, Geoffrey P.; et al, Nucleic Acids Research, 2006, 34(6), 1884-1891

Production Method 2

Reaction Conditions
Reference
Synthesis of nucleosides
Vorbrueggen, Helmut; Ruh-Pohlenz, Carmen, Organic Reactions (Hoboken, 2000, 55,

Production Method 3

Reaction Conditions
1.1 Reagents: Lithium sulfide Solvents: Tetrahydrofuran
1.2 Reagents: Sodium methoxide Solvents: Methanol
Reference
Straightforward synthesis of 6-thiodeoxyguanosine and its incorporation into oligodeoxynucleotides
Waters, Timothy R.; Connolly, Bernard A., Nucleosides & Nucleotides, 1992, 11(5), 985-98

Production Method 4

Reaction Conditions
1.1 Reagents: Pyridine ,  Trifluoroacetic anhydride Solvents: Pyridine
1.2 Reagents: Sodium hydrosulfide Solvents: Dimethylformamide
Reference
One-flask syntheses of 6-thioguanosine and 2'-deoxy-6-thioguanosine
Kung, Pei Pei; Jones, Roger A., Tetrahedron Letters, 1991, 32(32), 3919-22

Production Method 5

Reaction Conditions
1.1 Reagents: Sodium methoxide ,  Hydrogen sulfide Solvents: Methanol
Reference
Convenient synthesis of 2'-deoxy-6-thioguanosine, ara-guanine, ara-6-thioguanine and certain related purine nucleosides by the stereospecific sodium salt glycosylation procedure
Hanna, Naeem B.; Ramasamy, Kandasamy; Robins, Roland K.; Revankar, Ganapathi R., Journal of Heterocyclic Chemistry, 1988, 25(6), 1899-903

Production Method 6

Reaction Conditions
1.1 Reagents: Sodium methoxide Solvents: Methanol
Reference
Straightforward synthesis of 6-thiodeoxyguanosine and its incorporation into oligodeoxynucleotides
Waters, Timothy R.; Connolly, Bernard A., Nucleosides & Nucleotides, 1992, 11(8), 1561-74

Production Method 7

Reaction Conditions
1.1 Reagents: Sodium acetate Solvents: Water
Reference
Biocatalytic synthesis of base-modified 2'-deoxy-β-D-ribonucleosides with bacterial whole cells
Pal, Suresh; Nair, Vasu, Biotechnology Letters, 1997, 19(4), 349-351

6-Thio-2'-Deoxyguanosine Raw materials

6-Thio-2'-Deoxyguanosine Preparation Products

6-Thio-2'-Deoxyguanosine Suppliers

NewCan Biotech Limited
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(CAS:789-61-7)6-Thio-2'-Deoxyguanosine
Order Number:NC13853
Stock Status:
Quantity:10g
Purity:97%
Pricing Information Last Updated:Friday, 18 July 2025 16:02
Price ($):Price inquiry

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NewCan Biotech Limited
(CAS:789-61-7)6-Thio-2'-Deoxyguanosine
NC13853
Purity:97%
Quantity:10g
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