Production Method 1

619-66-9

100-51-6

78767-55-2

Reaction Conditions

1.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ;  overnight, rt

Reference

Stoichiometric imbalance-promoted step-growth polymerization based on self-accelerating 1,3-dipolar cycloaddition click reactions

Liu, Xianfeng; Xiang, Lue; Li, Jiayi; Wu, Ying; Zhang, Ke, Polymer Chemistry, 2020, 11(1), 125-134

Production Method 2

619-66-9

78767-55-2

Reaction Conditions

1.1 Reagents: Cesium carbonate Solvents: Dimethylformamide ;  30 min, rt
1.2 3 h, rt

Reference

Combined Cardioprotective and Adipocyte Browning Effects Promoted by the Eutomer of Dual sEH/PPARγ Modulator

Hartmann, Markus; Bibli, Sofia-Iris; Tews, Daniel; Ni, Xiaomin; Kircher, Theresa; et al, Journal of Medicinal Chemistry, 2021, 64(5), 2815-2828

Production Method 3

619-66-9

78767-55-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  30 min, rt
1.2 rt; 3 h, rt

Reference

Design, synthesis and biological evaluation of benzimidazole derivatives as novel human Pin1 inhibitors

Ma, Tianyi; Huang, Min; Li, Aihua; Zhao, Feng; Li, Deyi; et al, Bioorganic & Medicinal Chemistry Letters, 2019, 29(14), 1859-1863

Production Method 4

619-66-9

78767-55-2

Reaction Conditions

1.1 Reagents: Cesium carbonate ,  Oxygen Solvents: Dimethylformamide ;  20 min, rt
1.2 24 h, rt

Reference

Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia

Toutah, Krimo; Nawar, Nabanita; Timonen, Sanna; Sorger, Helena; Raouf, Yasir S.; et al, Journal of Medicinal Chemistry, 2021, 64(12), 8486-8509

Production Method 5

619-66-9

100-51-6

78767-55-2

Reaction Conditions

1.1 Reagents: Triphenylphosphine ,  Diisopropyl azodicarboxylate Solvents: Toluene ;  10 min, rt
1.2 overnight, rt

Reference

Spatially Resolved Covalent Functionalization Patterns on Graphene

Valenta, Leos; Kovaricek, Petr; Vales, Vaclav; Bastl, Zdenek; Drogowska, Karolina A.; et al, Angewandte Chemie, 2019, 58(5), 1324-1328

Production Method 6

619-66-9

78767-55-2

Reaction Conditions

1.1 Reagents: Cesium carbonate Solvents: Dimethylformamide ;  3 h, rt

Reference

Scalable synthesis of an integrin-binding peptide mimetic for biomedical applications

Riches, Andrew G.; Cablewski, Teresa; Glattauer, Veronica; Thissen, Helmut; Meagher, Laurence, Tetrahedron, 2012, 68(46), 9448-9455

Production Method 7

619-66-9

31139-36-3

78767-55-2

Reaction Conditions

1.1 Catalysts: Magnesium perchlorate Solvents: Nitromethane ;  overnight, 40 °C

Reference

Lewis acids as highly efficient catalysts for the decarboxylative esterification of carboxylic acids with dialkyl dicarbonates

Goossen, L.; Doehring, A., Advanced Synthesis & Catalysis, 2003, 345(8), 943-947

Production Method 8

619-66-9

78767-55-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  rt; 12 h, rt

Reference

Pd-Catalyzed Debenzylation and Deallylation of Ethers and Esters with Sodium Hydride

Mao, Yujian; Liu, Ye; Hu, Yanwei; Wang, Liang; Zhang, Shilei; et al, ACS Catalysis, 2018, 8(4), 3016-3020

Production Method 9

619-66-9

100-51-6

78767-55-2

Reaction Conditions

1.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ;  2 h, rt

Reference

Investigating the Cusp between the nano- and macro-sciences in supermolecular liquid-crystalline twist-bend nematogens

Simpson, Frank P.; Mandle, Richard J.; Moore, John N.; Goodby, John W., Journal of Materials Chemistry C: Materials for Optical and Electronic Devices, 2017, 5(21), 5102-5110

Production Method 10

619-66-9

78767-55-2

Reaction Conditions

1.1 Reagents: Cesium carbonate Solvents: Dimethylformamide ;  3 h, rt

Reference

Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor

Mori, Mattia; Moraca, Francesca; Deodato, Davide; Ferraris, Davide M.; Selchow, Petra; et al, Bioorganic & Medicinal Chemistry Letters, 2014, 24(11), 2508-2511

Production Method 11

619-66-9

78767-55-2

Reaction Conditions

1.1 Reagents: Cesium carbonate Solvents: Methanol ,  Water ;  20 h, pH 8, 25 °C
1.2 Solvents: Dimethylformamide ;  18 h, 25 °C

Reference

Polyaldol Synthesis by Direct Organocatalyzed Crossed Polymerization of Bis(ketones) and Bis(aldehydes)

Liu, Na; Martin, Anthony; Robert, Frederic; Vincent, Jean-Marc; Landais, Yannick; et al, Macromolecules (Washington, 2014, 47(2), 525-533

Production Method 12

619-66-9

100-51-6

78767-55-2

Reaction Conditions

1.1 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ;  0 °C; 12 h, rt

Reference

Synthesis, characterization, and antifungal evaluation of thiolactomycin derivatives

Lv, Pei; Chen, Yiliang; Wang, Dawei; Wu, Xiangwei; Li, Qing X.; et al, Engineering (Beijing, 2020, 6(5), 560-568

Production Method 13

619-66-9

78767-55-2

Reaction Conditions

1.1 Reagents: Cesium carbonate ,  Oxygen Solvents: Dimethylformamide ;  20 min, rt
1.2 24 h, rt

Reference

Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma

Nawar, Nabanita; Bukhari, Shazreh; Adile, Ashley A.; Suk, Yujin; Manaswiyoungkul, Pimyupa; et al, Journal of Medicinal Chemistry, 2022, 65(4), 3193-3217

Production Method 14

619-66-9

78767-55-2

Reaction Conditions

1.1 Reagents: Cesium carbonate Solvents: Dimethylformamide ;  20 min, rt
1.2 24 h, rt

Reference

PTG-0861: A novel HDAC6-selective inhibitor as a therapeutic strategy in acute myeloid leukaemia

Gawel, Justyna M.; Shouksmith, Andrew E.; Raouf, Yasir S.; Nawar, Nabanita; Toutah, Krimo; et al, European Journal of Medicinal Chemistry, 2020, 201,

Production Method 15

619-66-9

78767-55-2

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ;  rt; 45 min, rt
1.2 rt; 5 h, rt

Reference

Benzamide capped peptidomimetics as non-ATP competitive inhibitors of CDK2 using the REPLACE strategy

Premnath, Padmavathy Nandha; Craig, Sandra N.; Liu, Shu; McInnes, Campbell, Bioorganic & Medicinal Chemistry Letters, 2016, 26(15), 3754-3760

Benzoic acid,4-formyl-, phenylmethyl ester Raw materials

• 4-Carboxybenzaldehyde
• Benzyl alcohol
• Dibenzyl Dicarbonate

Benzoic acid,4-formyl-, phenylmethyl ester Preparation Products

• Benzoic acid,4-formyl-, phenylmethyl ester (78767-55-2)

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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acid esters

• 120-51-4(Benzyl benzoate)
• 4105-92-4(Triethyl benzene-1,3,5-tricarboxylate)
• 153467-69-7(Ethyl, 1-(benzoyloxy)-(9CI))
• 636-53-3(Diethyl isophthalate)
• 120-33-2(Ethyl 3-methylbenzoate)
• 19851-61-7(Dibenzyl terephthalate)
• 21239-29-2(Ethyl 3,5-dimethylbenzoate)
• 94-08-6(Ethyl p-toluate)
• 636-09-9(Diethyl terephthalate)
• 33745-47-0(3-Formylbenzoic Acid Ethyl Ester)