Production Method 1

2786781-65-3

769108-87-4

Reaction Conditions

1.1 Reagents: Potassium bis(trimethylsilyl)amide Solvents: Toluene ,  Tetrahydrofuran ;  -78 °C; 30 min, -78 °C
1.2 Reagents: Oxygen ;  -78 °C → 21 °C; 30 min, 21 °C
1.3 Reagents: Sodium hydroxide ,  Sodium thiosulfate Solvents: Water

Reference

A Pyridine Dearomatization Approach to the Matrine-Type Lupin Alkaloids

Kerkovius, Jeff K. ; Stegner, Andrea ; Turlik, Aneta ; Lam, Pik Hoi; Houk, Kendall N. ; et al, Journal of the American Chemical Society, 2022, 144(35), 15938-15943

Production Method 2

769108-87-4

4702-09-4

4979-18-4

Reaction Conditions

1.1 Reagents: Triethylamine ,  Hydrogen Catalysts: Palladium Solvents: Ethanol ;  rt → 70 °C; 6 h, 70 °C

Reference

Total synthesis of matrine alkaloids

Magann, Nicholas L.; Westley, Erin; Sowden, Madison J.; Gardiner, Michael G.; Sherburn, Michael S., ChemRxiv, 2022, 1, 1-5

Production Method 3

769108-87-4

4702-09-4

4979-18-4

Reaction Conditions

1.1 Reagents: Triethylamine ,  Hydrogen Catalysts: Palladium Solvents: Ethanol ;  rt → 70 °C; 6 h, 70 °C

Reference

Total Synthesis of Matrine Alkaloids

Magann, Nicholas L. ; Westley, Erin; Sowden, Madison J.; Gardiner, Michael G.; Sherburn, Michael S., Journal of the American Chemical Society, 2022, 144(43), 19695-19699

Matrine Impurity 7 Raw materials

• rel-(7aR,10R,13aR,13bS,13cR)-Dodecahydro-1H,5H,8H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridine-10-carbonitrile

Matrine Impurity 7 Preparation Products

• Matrine Impurity 7 (769108-87-4)
• (+)-Matrin (4702-09-4)
• (+)-Matrin (4979-18-4)

• 1. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 2. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 3. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 4. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 5. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
  LarsBanko,AlfredLudwig

• Solvents and Organic Chemicals Organic Compounds Alkaloids and derivatives Lupin alkaloids Matrine alkaloids

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• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)